ENSG00000118961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237822 ENSG00000118961 HEK293_OSMI2_6hA HEK293_TMG_6hB LDAH protein_coding protein_coding 4.657691 1.811727 7.807543 0.5440467 0.7029622 2.101408 1.35408495 0.4902826 2.6312467 0.26251463 0.21486465 2.400403838 0.35510000 0.20736667 0.33813333 0.1307666667 7.864121e-01 1.881634e-06 FALSE TRUE
ENST00000432947 ENSG00000118961 HEK293_OSMI2_6hA HEK293_TMG_6hB LDAH protein_coding protein_coding 4.657691 1.811727 7.807543 0.5440467 0.7029622 2.101408 0.16240428 0.2244303 0.3186203 0.22443028 0.31862030 0.487262714 0.02832500 0.08653333 0.03476667 -0.0517666667 9.200166e-01 1.881634e-06 FALSE FALSE
ENST00000440866 ENSG00000118961 HEK293_OSMI2_6hA HEK293_TMG_6hB LDAH protein_coding protein_coding 4.657691 1.811727 7.807543 0.5440467 0.7029622 2.101408 0.33584182 0.2740677 0.6172693 0.07001906 0.05347476 1.142850024 0.08578333 0.20953333 0.07956667 -0.1299666667 6.047862e-01 1.881634e-06 TRUE TRUE
ENST00000470099 ENSG00000118961 HEK293_OSMI2_6hA HEK293_TMG_6hB LDAH protein_coding retained_intron 4.657691 1.811727 7.807543 0.5440467 0.7029622 2.101408 0.08767318 0.2258927 0.0000000 0.22589274 0.00000000 -4.560059111 0.02951667 0.08710000 0.00000000 -0.0871000000 6.680638e-01 1.881634e-06 TRUE TRUE
ENST00000541941 ENSG00000118961 HEK293_OSMI2_6hA HEK293_TMG_6hB LDAH protein_coding protein_coding 4.657691 1.811727 7.807543 0.5440467 0.7029622 2.101408 0.43335613 0.2639921 0.2635375 0.13734109 0.13693984 -0.002395866 0.12517500 0.21796667 0.03733333 -0.1806333333 7.594218e-01 1.881634e-06 FALSE TRUE
ENST00000626491 ENSG00000118961 HEK293_OSMI2_6hA HEK293_TMG_6hB LDAH protein_coding protein_coding 4.657691 1.811727 7.807543 0.5440467 0.7029622 2.101408 0.41894298 0.2187211 0.7822169 0.17578624 0.18724949 1.792305944 0.07221667 0.10246667 0.10203333 -0.0004333333 8.991731e-01 1.881634e-06 FALSE TRUE
MSTRG.18024.10 ENSG00000118961 HEK293_OSMI2_6hA HEK293_TMG_6hB LDAH protein_coding   4.657691 1.811727 7.807543 0.5440467 0.7029622 2.101408 0.69883544 0.0000000 1.6569320 0.00000000 0.30348190 7.381051428 0.08905833 0.00000000 0.21013333 0.2101333333 1.881634e-06 1.881634e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118961 E001 0.2617363 0.058762775 0.0297938656   2 20684014 20684027 14 - 0.000 0.341 11.310
ENSG00000118961 E002 0.2617363 0.058762775 0.0297938656   2 20684028 20684030 3 - 0.000 0.341 13.599
ENSG00000118961 E003 0.9103477 0.016383098 0.0018308401   2 20684031 20684043 13 - 0.069 0.603 4.122
ENSG00000118961 E004 16.9589203 0.002247768 0.5154581053 0.711948597 2 20684044 20684411 368 - 1.171 1.237 0.233
ENSG00000118961 E005 9.8995487 0.003967234 0.0590464878 0.200621258 2 20684412 20684536 125 - 0.898 1.116 0.803
ENSG00000118961 E006 11.2156388 0.003555869 0.0113920396 0.063963180 2 20684537 20684635 99 - 0.935 1.206 0.987
ENSG00000118961 E007 11.5269073 0.029512621 0.0732558703 0.231327402 2 20684636 20684718 83 - 0.962 1.188 0.821
ENSG00000118961 E008 6.2803859 0.024862042 0.4740875253 0.682887360 2 20684719 20684720 2 - 0.767 0.882 0.448
ENSG00000118961 E009 12.8324209 0.004370240 0.3100491112 0.550515142 2 20684721 20684856 136 - 1.042 1.154 0.403
ENSG00000118961 E010 6.9358440 0.007157571 0.9570851454 0.980414464 2 20684857 20684875 19 - 0.837 0.847 0.039
ENSG00000118961 E011 6.2016768 0.004842640 0.6442177476 0.799619104 2 20684876 20684923 48 - 0.779 0.847 0.267
ENSG00000118961 E012 46.8869334 0.014454912 0.3741080409 0.607415141 2 20684924 20685546 623 - 1.591 1.673 0.280
ENSG00000118961 E013 28.3646366 0.005605821 0.7184432930 0.847273251 2 20685547 20685657 111 - 1.384 1.419 0.120
ENSG00000118961 E014 100.2723492 0.006404204 0.4333137418 0.653696531 2 20685658 20686624 967 - 1.918 1.960 0.142
ENSG00000118961 E015 38.8261771 0.001674240 0.9856241004 0.994626063 2 20686625 20686837 213 - 1.522 1.526 0.011
ENSG00000118961 E016 26.3544507 0.012152497 0.4479611826 0.664212504 2 20686838 20686906 69 - 1.382 1.306 -0.265
ENSG00000118961 E017 36.4522286 0.001471843 0.9947355739 0.998953197 2 20686907 20687094 188 - 1.504 1.509 0.017
ENSG00000118961 E018 10.9420747 0.004067964 0.9597746143 0.981777796 2 20701570 20701574 5 - 1.014 1.026 0.045
ENSG00000118961 E019 25.7180236 0.001720132 0.7806410956 0.885103570 2 20701575 20701652 78 - 1.360 1.344 -0.057
ENSG00000118961 E020 24.1189428 0.001530934 0.6862135119 0.826629195 2 20739971 20740051 81 - 1.334 1.307 -0.094
ENSG00000118961 E021 37.3153673 0.003309220 0.0481708986 0.175416029 2 20740052 20740205 154 - 1.538 1.399 -0.479
ENSG00000118961 E022 25.6033488 0.012489534 0.0732565570 0.231327402 2 20774810 20774857 48 - 1.385 1.207 -0.626
ENSG00000118961 E023 33.9516594 0.002202918 0.0557906197 0.193152785 2 20774858 20774979 122 - 1.495 1.356 -0.479
ENSG00000118961 E024 0.0000000       2 20788889 20789340 452 -      
ENSG00000118961 E025 27.4436309 0.003837166 0.0001159053 0.001689851 2 20790255 20790398 144 - 1.433 1.074 -1.267
ENSG00000118961 E026 0.6765862 0.252961059 0.4371948643   2 20801292 20801309 18 - 0.231 0.000 -11.594
ENSG00000118961 E027 22.9461845 0.006099993 0.1673546479 0.387046673 2 20801310 20801465 156 - 1.328 1.205 -0.430
ENSG00000118961 E028 14.1276022 0.002906874 0.0291443765 0.124782812 2 20823037 20823130 94 - 1.049 1.266 0.774