ENSG00000118900

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262376 ENSG00000118900 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN1 protein_coding protein_coding 28.3142 38.15893 23.46415 1.468081 0.8917135 -0.701326 5.4398696 6.4305141 2.9423591 0.7016251 0.1344469 -1.1253076 0.19811667 0.16773333 0.125366667 -0.04236667 0.40512673 0.01222871 FALSE TRUE
ENST00000589191 ENSG00000118900 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN1 protein_coding nonsense_mediated_decay 28.3142 38.15893 23.46415 1.468081 0.8917135 -0.701326 5.3363243 9.1887096 0.2100136 0.8629598 0.2100136 -5.3857666 0.16587500 0.23993333 0.008866667 -0.23106667 0.01222871 0.01222871 FALSE FALSE
ENST00000590769 ENSG00000118900 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN1 protein_coding protein_coding 28.3142 38.15893 23.46415 1.468081 0.8917135 -0.701326 7.8197205 9.1741535 5.9434154 0.2069257 0.6173383 -0.6254292 0.27831250 0.24156667 0.253800000 0.01223333 0.97293491 0.01222871 FALSE TRUE
MSTRG.11993.13 ENSG00000118900 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN1 protein_coding   28.3142 38.15893 23.46415 1.468081 0.8917135 -0.701326 1.7828516 5.3118193 0.5721545 0.4758334 0.3908338 -3.1924455 0.05613333 0.13873333 0.025500000 -0.11323333 0.27038170 0.01222871 FALSE TRUE
MSTRG.11993.5 ENSG00000118900 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN1 protein_coding   28.3142 38.15893 23.46415 1.468081 0.8917135 -0.701326 0.9706773 0.8060821 1.9756127 0.2784925 0.8943650 1.2827980 0.03754167 0.02170000 0.087433333 0.06573333 0.39735657 0.01222871 FALSE TRUE
MSTRG.11993.6 ENSG00000118900 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN1 protein_coding   28.3142 38.15893 23.46415 1.468081 0.8917135 -0.701326 2.2052468 1.9913512 3.0856084 1.0467535 0.2579225 0.6292486 0.08262500 0.05016667 0.132233333 0.08206667 0.70315947 0.01222871 FALSE TRUE
MSTRG.11993.7 ENSG00000118900 HEK293_OSMI2_6hA HEK293_TMG_6hB UBN1 protein_coding   28.3142 38.15893 23.46415 1.468081 0.8917135 -0.701326 2.6022998 2.2312584 6.4598017 0.7412695 2.1659153 1.5294125 0.10207083 0.05793333 0.270066667 0.21213333 0.11307050 0.01222871 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118900 E001 4.1346415 0.0096111775 5.533318e-01 7.385949e-01 16 4846665 4847480 816 + 0.743 0.657 -0.359
ENSG00000118900 E002 83.0111268 0.0017452424 8.208023e-07 2.392570e-05 16 4847481 4848170 690 + 1.759 1.987 0.768
ENSG00000118900 E003 26.7075757 0.0029717891 7.051313e-01 8.388030e-01 16 4848171 4848210 40 + 1.417 1.443 0.093
ENSG00000118900 E004 2.2024089 0.0092884457 7.148787e-01 8.448531e-01 16 4848211 4848287 77 + 0.540 0.480 -0.291
ENSG00000118900 E005 2.1726692 0.0099115769 3.720691e-01 6.056466e-01 16 4848288 4848294 7 + 0.589 0.442 -0.706
ENSG00000118900 E006 2.5064593 0.0088597939 3.408340e-01 5.787798e-01 16 4848295 4848312 18 + 0.633 0.480 -0.706
ENSG00000118900 E007 2.5423560 0.0125507641 6.548779e-01 8.066610e-01 16 4848313 4848317 5 + 0.589 0.515 -0.340
ENSG00000118900 E008 5.1333054 0.0056245200 3.224303e-01 5.618746e-01 16 4848318 4848379 62 + 0.856 0.724 -0.524
ENSG00000118900 E009 4.2927308 0.0059290451 5.047878e-01 7.041693e-01 16 4848380 4848393 14 + 0.774 0.680 -0.384
ENSG00000118900 E010 1.6687786 0.6858908560 9.639731e-01 9.839034e-01 16 4852215 4852878 664 + 0.504 0.350 -0.825
ENSG00000118900 E011 153.8431731 0.0022728204 3.348105e-05 5.927702e-04 16 4852879 4853139 261 + 2.265 2.114 -0.506
ENSG00000118900 E012 86.3728641 0.0069681396 3.901944e-05 6.742367e-04 16 4853140 4853166 27 + 2.054 1.824 -0.774
ENSG00000118900 E013 0.6316833 0.0262739265 1.386925e-01   16 4854957 4855083 127 + 0.350 0.098 -2.294
ENSG00000118900 E014 140.8902326 0.0004444655 8.795348e-11 6.310318e-09 16 4857990 4858076 87 + 2.251 2.052 -0.667
ENSG00000118900 E015 93.6355540 0.0056739374 9.471173e-05 1.428313e-03 16 4858568 4858573 6 + 2.077 1.879 -0.665
ENSG00000118900 E016 175.3428399 0.0024474198 2.434045e-05 4.515588e-04 16 4858574 4858663 90 + 2.321 2.172 -0.495
ENSG00000118900 E017 3.8193403 0.0254686534 3.489254e-01 5.863315e-01 16 4858878 4859024 147 + 0.773 0.630 -0.594
ENSG00000118900 E018 204.9222594 0.0002791903 2.708571e-07 9.015634e-06 16 4859025 4859159 135 + 2.379 2.248 -0.435
ENSG00000118900 E019 202.7390763 0.0002466726 3.238866e-08 1.350771e-06 16 4859865 4859968 104 + 2.378 2.238 -0.467
ENSG00000118900 E020 151.6111469 0.0003385516 7.608534e-07 2.240125e-05 16 4860664 4860744 81 + 2.253 2.107 -0.489
ENSG00000118900 E021 211.1777627 0.0010496391 2.138185e-01 4.461353e-01 16 4860745 4860953 209 + 2.333 2.296 -0.123
ENSG00000118900 E022 155.7502100 0.0030330117 4.290667e-01 6.503401e-01 16 4860954 4861058 105 + 2.200 2.168 -0.109
ENSG00000118900 E023 117.9319277 0.0027696952 3.685766e-02 1.465496e-01 16 4861059 4861102 44 + 2.113 2.026 -0.294
ENSG00000118900 E024 103.6516894 0.0004774053 2.916123e-03 2.289951e-02 16 4868833 4868903 71 + 2.069 1.962 -0.357
ENSG00000118900 E025 144.2351319 0.0003232762 6.764911e-01 8.205278e-01 16 4870212 4870341 130 + 2.156 2.143 -0.042
ENSG00000118900 E026 207.2495025 0.0004430201 4.400415e-01 6.587666e-01 16 4870516 4870634 119 + 2.315 2.295 -0.069
ENSG00000118900 E027 175.6674871 0.0019209114 9.456571e-01 9.751666e-01 16 4870844 4870887 44 + 2.232 2.229 -0.011
ENSG00000118900 E028 212.0480859 0.0018117688 6.536806e-01 8.059095e-01 16 4870888 4870972 85 + 2.304 2.317 0.045
ENSG00000118900 E029 224.1012364 0.0006305683 1.060151e-01 2.923714e-01 16 4871155 4871301 147 + 2.310 2.353 0.143
ENSG00000118900 E030 4.7480051 0.0672847577 9.795807e-01 9.916092e-01 16 4872188 4872327 140 + 0.744 0.731 -0.052
ENSG00000118900 E031 134.7526130 0.0003521028 1.888242e-01 4.155170e-01 16 4872884 4872934 51 + 2.144 2.103 -0.138
ENSG00000118900 E032 132.6668319 0.0002997688 3.348581e-01 5.734440e-01 16 4873031 4873073 43 + 2.130 2.100 -0.102
ENSG00000118900 E033 782.8400661 0.0009951051 4.451662e-01 6.621980e-01 16 4874211 4875271 1061 + 2.872 2.886 0.046
ENSG00000118900 E034 250.6718532 0.0002096874 9.078253e-01 9.560644e-01 16 4875272 4875434 163 + 2.385 2.388 0.010
ENSG00000118900 E035 154.5574705 0.0003797075 4.482925e-01 6.644937e-01 16 4876871 4876947 77 + 2.194 2.172 -0.074
ENSG00000118900 E036 163.7214590 0.0002768288 8.320610e-01 9.150155e-01 16 4876948 4877022 75 + 2.209 2.203 -0.019
ENSG00000118900 E037 165.5351436 0.0008234342 2.953568e-01 5.358236e-01 16 4877023 4877111 89 + 2.189 2.222 0.110
ENSG00000118900 E038 129.4588206 0.0011338785 4.608201e-02 1.702257e-01 16 4877385 4877474 90 + 2.058 2.130 0.240
ENSG00000118900 E039 11.5573293 0.1208163594 8.816960e-01 9.422457e-01 16 4877475 4877813 339 + 1.070 1.089 0.069
ENSG00000118900 E040 1824.0161497 0.0001109713 3.737753e-44 8.816060e-41 16 4880083 4882401 2319 + 3.171 3.288 0.388