ENSG00000118816

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237654 ENSG00000118816 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNI protein_coding protein_coding 114.0851 120.7888 114.8519 30.63945 5.621805 -0.07270535 95.057209 106.91206 80.98093 29.594652 3.0978409 -0.4007274 0.82416250 0.8689667 0.70596667 -0.16300000 4.166222e-02 1.176003e-47 FALSE TRUE
ENST00000505609 ENSG00000118816 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNI protein_coding protein_coding 114.0851 120.7888 114.8519 30.63945 5.621805 -0.07270535 2.707979 0.00000 9.61829 0.000000 0.3439301 9.9111357 0.02402917 0.0000000 0.08383333 0.08383333 1.176003e-47 1.176003e-47 FALSE FALSE
ENST00000515468 ENSG00000118816 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNI protein_coding protein_coding 114.0851 120.7888 114.8519 30.63945 5.621805 -0.07270535 15.621830 13.14301 23.67415 1.710388 2.7557723 0.8485285 0.14492083 0.1219667 0.20486667 0.08290000 3.330591e-01 1.176003e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118816 E001 2893.1967584 2.069606e-03 6.049146e-10 3.666253e-08 4 77047155 77048114 960 - 3.359 3.518 0.528
ENSG00000118816 E002 2451.5858324 9.283655e-05 2.157556e-01 4.483524e-01 4 77048115 77048662 548 - 3.363 3.402 0.128
ENSG00000118816 E003 843.5341826 1.429931e-04 3.716305e-01 6.053097e-01 4 77055150 77055233 84 - 2.911 2.928 0.057
ENSG00000118816 E004 922.4518996 4.648650e-04 3.799317e-01 6.121143e-01 4 77055234 77055322 89 - 2.953 2.966 0.042
ENSG00000118816 E005 756.7757522 2.161602e-03 9.277033e-01 9.659256e-01 4 77055323 77055380 58 - 2.864 2.883 0.061
ENSG00000118816 E006 793.0373150 3.760602e-04 6.507833e-04 7.014787e-03 4 77055962 77056043 82 - 2.910 2.885 -0.084
ENSG00000118816 E007 504.3279588 2.403472e-04 2.910437e-05 5.256398e-04 4 77056044 77056064 21 - 2.723 2.681 -0.142
ENSG00000118816 E008 546.2853711 2.095884e-04 6.772991e-04 7.244047e-03 4 77056065 77056100 36 - 2.747 2.721 -0.088
ENSG00000118816 E009 441.1558321 1.370887e-03 2.115589e-05 4.008431e-04 4 77056101 77056102 2 - 2.679 2.606 -0.245
ENSG00000118816 E010 722.5164498 5.408347e-04 3.482291e-05 6.127584e-04 4 77056249 77056323 75 - 2.876 2.836 -0.132
ENSG00000118816 E011 3.0556075 8.373813e-03 6.333525e-01 7.925363e-01 4 77056324 77056485 162 - 0.635 0.583 -0.229
ENSG00000118816 E012 374.1689301 1.852259e-04 6.845620e-05 1.088932e-03 4 77058507 77058509 3 - 2.596 2.550 -0.153
ENSG00000118816 E013 610.1378621 1.098479e-04 2.961697e-08 1.248050e-06 4 77058510 77058558 49 - 2.811 2.759 -0.174
ENSG00000118816 E014 726.0568791 1.338723e-04 3.115470e-08 1.305722e-06 4 77058559 77058617 59 - 2.884 2.837 -0.158
ENSG00000118816 E015 519.1032887 2.135403e-04 1.427055e-04 2.012847e-03 4 77058618 77058635 18 - 2.732 2.697 -0.116
ENSG00000118816 E016 0.3206185 2.744240e-02 1.318919e-01   4 77064713 77065080 368 - 0.240 0.000 -10.734
ENSG00000118816 E017 0.3503582 7.319896e-02 8.291147e-01   4 77066165 77066248 84 - 0.136 0.108 -0.380
ENSG00000118816 E018 902.5964039 8.816978e-04 4.137847e-03 2.993280e-02 4 77066249 77066405 157 - 2.967 2.940 -0.090
ENSG00000118816 E019 0.8815333 4.426788e-02 9.261707e-02   4 77074790 77074910 121 - 0.394 0.108 -2.380
ENSG00000118816 E020 2.8541431 1.273746e-02 3.023625e-01 5.429641e-01 4 77075099 77075471 373 - 0.453 0.644 0.888
ENSG00000118816 E021 737.7853334 3.298530e-03 4.339762e-04 5.069414e-03 4 77075472 77076368 897 - 2.784 2.917 0.442