ENSG00000118579

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237380 ENSG00000118579 HEK293_OSMI2_6hA HEK293_TMG_6hB MED28 protein_coding protein_coding 84.42083 38.37235 109.8307 5.708842 4.860184 1.516897 3.855744 3.418817 3.80457 0.2467014 0.2494779 0.1538096 0.05312083 0.0954000 0.03456667 -0.06083333 0.02957443 0.02957443 FALSE  
MSTRG.24672.1 ENSG00000118579 HEK293_OSMI2_6hA HEK293_TMG_6hB MED28 protein_coding   84.42083 38.37235 109.8307 5.708842 4.860184 1.516897 65.613151 28.471085 84.15140 5.2173978 4.0710669 1.5631546 0.77027500 0.7327333 0.76590000 0.03316667 0.85526683 0.02957443 FALSE  
MSTRG.24672.2 ENSG00000118579 HEK293_OSMI2_6hA HEK293_TMG_6hB MED28 protein_coding   84.42083 38.37235 109.8307 5.708842 4.860184 1.516897 14.572769 6.261009 21.71243 0.6545368 0.5929637 1.7924158 0.17137083 0.1659000 0.19803333 0.03213333 0.55977834 0.02957443 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118579 E001 3.2730724 0.10590909 0.873109973 0.93766659 4 17614608 17614631 24 + 0.585 0.668 0.362
ENSG00000118579 E002 11.5921045 0.17608919 0.270116179 0.51008495 4 17614632 17614640 9 + 1.136 0.995 -0.513
ENSG00000118579 E003 16.7043164 0.17633734 0.335507253 0.57402102 4 17614641 17614647 7 + 1.276 1.168 -0.383
ENSG00000118579 E004 184.3958419 0.15056262 0.186524728 0.41247762 4 17614648 17614663 16 + 2.311 2.162 -0.498
ENSG00000118579 E005 448.8357912 0.16963475 0.194492972 0.42272196 4 17614664 17614813 150 + 2.690 2.561 -0.430
ENSG00000118579 E006 428.9089426 0.11198400 0.132589310 0.33587546 4 17619901 17619967 67 + 2.668 2.545 -0.410
ENSG00000118579 E007 0.6081007 0.01989585 0.096543479   4 17619968 17620081 114 + 0.307 0.000 -10.852
ENSG00000118579 E008 452.1385415 0.02528871 0.025374152 0.11335897 4 17621587 17621699 113 + 2.684 2.583 -0.334
ENSG00000118579 E009 544.1825871 1.50293821 0.614056908 0.77957636 4 17623601 17623794 194 + 2.734 2.715 -0.061
ENSG00000118579 E010 1399.9469682 1.64669078 0.637709501 0.79553453 4 17623795 17625655 1861 + 3.139 3.133 -0.019
ENSG00000118579 E011 38.6698574 0.17277418 0.061604271 0.20639643 4 17625656 17625845 190 + 1.460 1.735 0.937
ENSG00000118579 E012 212.5126524 0.99184724 0.222844743 0.45681743 4 17625846 17628005 2160 + 2.165 2.484 1.065
ENSG00000118579 E013 261.2303610 1.06742117 0.220512362 0.45410866 4 17628006 17630923 2918 + 2.241 2.583 1.140
ENSG00000118579 E014 39.2299164 0.14413832 0.006424522 0.04179402 4 17630924 17631375 452 + 1.357 1.814 1.560
ENSG00000118579 E015 73.9171922 0.32404144 0.033298981 0.13687692 4 17631376 17632285 910 + 1.642 2.074 1.454
ENSG00000118579 E016 122.1313388 0.45265336 0.030043716 0.12747636 4 17632286 17634105 1820 + 1.797 2.320 1.756
ENSG00000118579 E017 0.3453689 0.02702335 0.773152043   4 17653972 17654026 55 + 0.099 0.148 0.657