ENSG00000118564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341285 ENSG00000118564 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXL5 protein_coding protein_coding 34.97581 40.83628 26.10924 8.768206 1.394252 -0.6450916 0.9999392 0.3374947 1.614204 0.1605656 0.4387042 2.224670 0.0318500 0.007166667 0.06063333 0.05346667 8.778350e-03 1.90698e-27 FALSE TRUE
ENST00000412094 ENSG00000118564 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXL5 protein_coding protein_coding 34.97581 40.83628 26.10924 8.768206 1.394252 -0.6450916 3.9933838 0.8540425 7.665953 0.1924200 1.5359868 3.151172 0.1384000 0.021233333 0.28956667 0.26833333 2.518585e-12 1.90698e-27 FALSE TRUE
ENST00000507700 ENSG00000118564 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXL5 protein_coding retained_intron 34.97581 40.83628 26.10924 8.768206 1.394252 -0.6450916 1.5423823 0.0000000 3.201882 0.0000000 0.2367145 8.327275 0.0554625 0.000000000 0.12323333 0.12323333 1.906980e-27 1.90698e-27 FALSE TRUE
MSTRG.24650.14 ENSG00000118564 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXL5 protein_coding   34.97581 40.83628 26.10924 8.768206 1.394252 -0.6450916 17.5624999 25.7377903 7.457766 6.0029961 0.3490585 -1.785700 0.4674042 0.623966667 0.28870000 -0.33526667 5.583590e-07 1.90698e-27   FALSE
MSTRG.24650.16 ENSG00000118564 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXL5 protein_coding   34.97581 40.83628 26.10924 8.768206 1.394252 -0.6450916 7.7486086 12.2689624 3.312647 2.2947764 1.1980451 -1.885784 0.2051625 0.306266667 0.12266667 -0.18360000 1.733480e-01 1.90698e-27   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118564 E001 6.7003358 0.0047847155 2.313815e-04 3.016574e-03 4 15604381 15605005 625 - 0.765 0.870 0.412
ENSG00000118564 E002 159.0845192 0.0079432248 5.925028e-35 6.939352e-32 4 15605006 15605799 794 - 2.079 2.112 0.111
ENSG00000118564 E003 5.6300089 0.0123827708 2.482978e-09 1.339475e-07 4 15612013 15612265 253 - 0.777 0.233 -2.807
ENSG00000118564 E004 60.4449492 0.0207311927 2.555307e-15 4.067010e-13 4 15612266 15612414 149 - 1.675 1.651 -0.080
ENSG00000118564 E005 171.7178383 0.0125105216 2.730348e-35 3.335798e-32 4 15625252 15625977 726 - 2.132 2.044 -0.292
ENSG00000118564 E006 27.6570642 0.0016984328 1.433085e-16 2.689180e-14 4 15626873 15626955 83 - 1.335 1.376 0.144
ENSG00000118564 E007 47.2167563 0.0008719700 2.364614e-34 2.713282e-31 4 15627885 15628033 149 - 1.578 1.519 -0.201
ENSG00000118564 E008 53.4131669 0.0040295338 2.452949e-33 2.619919e-30 4 15630666 15630791 126 - 1.636 1.528 -0.370
ENSG00000118564 E009 0.3228314 0.3650472422 3.042167e-01   4 15636373 15636493 121 - 0.112 0.000 -8.827
ENSG00000118564 E010 53.7721336 0.0144561986 5.648169e-18 1.299714e-15 4 15636494 15636589 96 - 1.626 1.600 -0.089
ENSG00000118564 E011 44.7912550 0.0009732732 1.413870e-30 1.188651e-27 4 15636590 15636670 81 - 1.552 1.528 -0.082
ENSG00000118564 E012 26.0091816 0.0056116128 2.961705e-18 7.014862e-16 4 15636671 15636676 6 - 1.337 1.239 -0.346
ENSG00000118564 E013 33.4399896 0.0017227186 7.992231e-23 3.231582e-20 4 15638508 15638538 31 - 1.429 1.401 -0.097
ENSG00000118564 E014 27.9914289 0.0013394120 4.471723e-20 1.344073e-17 4 15638539 15638548 10 - 1.355 1.321 -0.118
ENSG00000118564 E015 52.8694114 0.0008540671 1.043517e-36 1.440757e-33 4 15638549 15638689 141 - 1.624 1.588 -0.123
ENSG00000118564 E016 24.7827053 0.0014482125 6.213623e-19 1.570262e-16 4 15638690 15638694 5 - 1.313 1.257 -0.197
ENSG00000118564 E017 39.9083310 0.0010626331 1.042342e-30 8.895159e-28 4 15640788 15640840 53 - 1.516 1.436 -0.275
ENSG00000118564 E018 28.8098306 0.0013420203 1.078952e-24 5.342006e-22 4 15640841 15640848 8 - 1.387 1.257 -0.453
ENSG00000118564 E019 34.6551959 0.0014034944 2.449555e-27 1.587751e-24 4 15640849 15640883 35 - 1.459 1.363 -0.332
ENSG00000118564 E020 0.7119354 1.2795177281 4.331127e-01   4 15641524 15641627 104 - 0.212 0.000 -9.925
ENSG00000118564 E021 51.9574207 0.0007129524 8.384683e-45 2.125242e-41 4 15644493 15644657 165 - 1.633 1.480 -0.523
ENSG00000118564 E022 28.6795048 0.0013256086 4.551234e-25 2.342134e-22 4 15644658 15644708 51 - 1.384 1.240 -0.506
ENSG00000118564 E023 23.4971577 0.0073784221 3.367347e-18 7.909447e-16 4 15655204 15655382 179 - 1.304 1.117 -0.664
ENSG00000118564 E024 0.6370325 0.1354159134 3.278167e-01   4 15656229 15656342 114 - 0.059 0.496 3.865
ENSG00000118564 E025 0.7914337 0.3110580063 7.955599e-01   4 15659727 15659730 4 - 0.156 0.388 1.742
ENSG00000118564 E026 0.7914337 0.3110580063 7.955599e-01   4 15659731 15659740 10 - 0.156 0.388 1.742
ENSG00000118564 E027 2.6540832 0.0087645916 8.267353e-01 9.118954e-01 4 15659741 15659922 182 - 0.365 0.825 2.113
ENSG00000118564 E028 31.7418894 0.1238699880 1.430987e-05 2.859154e-04 4 15667631 15667632 2 - 0.682 2.086 4.986
ENSG00000118564 E029 41.6752406 0.2018833065 2.362500e-04 3.071088e-03 4 15667633 15667640 8 - 0.781 2.202 4.974
ENSG00000118564 E030 161.5925538 0.9218150278 4.278742e-02 1.620032e-01 4 15667641 15667781 141 - 1.343 2.782 4.845
ENSG00000118564 E031 211.5518159 1.0091844295 4.153987e-02 1.587476e-01 4 15667782 15667915 134 - 1.431 2.903 4.945
ENSG00000118564 E032 178.9320470 0.8880503961 2.501213e-02 1.122495e-01 4 15667916 15668040 125 - 1.313 2.838 5.137
ENSG00000118564 E033 0.8571428 0.0172671820 6.678873e-01   4 15668499 15668561 63 - 0.158 0.385 1.702
ENSG00000118564 E034 2.2430395 0.0216360814 4.799475e-04 5.494548e-03 4 15672608 15672676 69 - 0.059 1.037 6.081
ENSG00000118564 E035 83.4144504 0.3661878051 1.149295e-03 1.104190e-02 4 15681280 15681352 73 - 0.990 2.510 5.200
ENSG00000118564 E036 100.9301289 0.4981827247 7.025985e-03 4.476193e-02 4 15681353 15681382 30 - 1.130 2.582 4.933
ENSG00000118564 E037 163.0236670 0.9380257565 4.702683e-02 1.726113e-01 4 15681383 15681679 297 - 1.361 2.784 4.789