ENSG00000118412

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237177 ENSG00000118412 HEK293_OSMI2_6hA HEK293_TMG_6hB CASP8AP2 protein_coding processed_transcript 8.889585 2.359216 18.28932 0.08655992 0.5746013 2.949308 0.1244113 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.07369583 0.00000000 0.00000000 0.000000000   1.595192e-10 FALSE TRUE
ENST00000548224 ENSG00000118412 HEK293_OSMI2_6hA HEK293_TMG_6hB CASP8AP2 protein_coding processed_transcript 8.889585 2.359216 18.28932 0.08655992 0.5746013 2.949308 0.2998278 0.1879383 0.2343393 0.09480599 0.08778180 0.3038347 0.09760417 0.08203333 0.01263333 -0.069400000 5.355522e-01 1.595192e-10 FALSE TRUE
ENST00000551025 ENSG00000118412 HEK293_OSMI2_6hA HEK293_TMG_6hB CASP8AP2 protein_coding protein_coding 8.889585 2.359216 18.28932 0.08655992 0.5746013 2.949308 2.5762832 0.0000000 5.8681559 0.00000000 0.84283992 9.1992198 0.16624583 0.00000000 0.31960000 0.319600000 1.595192e-10 1.595192e-10 FALSE TRUE
ENST00000552401 ENSG00000118412 HEK293_OSMI2_6hA HEK293_TMG_6hB CASP8AP2 protein_coding protein_coding 8.889585 2.359216 18.28932 0.08655992 0.5746013 2.949308 0.4471626 0.0000000 1.0273988 0.00000000 0.34814553 6.6968268 0.02935417 0.00000000 0.05583333 0.055833333 3.387274e-02 1.595192e-10 FALSE TRUE
MSTRG.28638.1 ENSG00000118412 HEK293_OSMI2_6hA HEK293_TMG_6hB CASP8AP2 protein_coding   8.889585 2.359216 18.28932 0.08655992 0.5746013 2.949308 4.2082814 1.8630722 7.5508785 0.23946584 0.62435967 2.0131474 0.45375000 0.78746667 0.41466667 -0.372800000 7.130902e-02 1.595192e-10 FALSE TRUE
MSTRG.28638.7 ENSG00000118412 HEK293_OSMI2_6hA HEK293_TMG_6hB CASP8AP2 protein_coding   8.889585 2.359216 18.28932 0.08655992 0.5746013 2.949308 0.4841375 0.1760056 1.5198092 0.17600561 0.04343457 3.0399337 0.07538333 0.07416667 0.08323333 0.009066667 6.980378e-01 1.595192e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118412 E001 0.1308682 0.032241363 7.529229e-02   6 89829869 89829880 12 + 0.000 0.249 21.276
ENSG00000118412 E002 0.4514866 0.022074468 4.393144e-01   6 89829881 89829887 7 + 0.103 0.249 1.533
ENSG00000118412 E003 1.0949365 0.014965849 9.261586e-01   6 89829888 89829893 6 + 0.256 0.249 -0.051
ENSG00000118412 E004 1.7383863 0.011835797 4.996076e-01 0.700479329 6 89829894 89829899 6 + 0.369 0.249 -0.788
ENSG00000118412 E005 10.2642163 0.049277499 5.461779e-01 0.733583538 6 89829900 89829930 31 + 0.930 0.897 -0.126
ENSG00000118412 E006 11.2226752 0.037099321 5.655390e-01 0.747067658 6 89829931 89829934 4 + 0.963 0.939 -0.090
ENSG00000118412 E007 7.8911260 0.092020096 9.502536e-01 0.977176966 6 89829935 89829938 4 + 0.813 0.896 0.322
ENSG00000118412 E008 8.7892976 0.094709053 9.731592e-01 0.988544138 6 89829939 89829940 2 + 0.854 0.934 0.304
ENSG00000118412 E009 24.5664851 0.026236233 7.127490e-01 0.843458069 6 89829941 89830067 127 + 1.270 1.289 0.066
ENSG00000118412 E010 3.3824916 0.007085579 9.268670e-02 0.268762300 6 89830068 89830106 39 + 0.581 0.250 -1.856
ENSG00000118412 E011 12.4307921 0.075788586 9.916733e-01 0.997570115 6 89830107 89831339 1233 + 0.982 1.050 0.251
ENSG00000118412 E012 5.8204721 0.161022482 6.796934e-01 0.822503208 6 89832264 89832320 57 + 0.681 0.855 0.696
ENSG00000118412 E013 39.0022593 0.017890841 2.307966e-01 0.466069332 6 89846562 89846644 83 + 1.470 1.411 -0.203
ENSG00000118412 E014 42.1370430 0.030263597 1.815283e-02 0.089535604 6 89853166 89853234 69 + 1.518 1.297 -0.765
ENSG00000118412 E015 19.0664872 0.063599952 1.357973e-02 0.072685621 6 89854817 89854820 4 + 1.205 0.809 -1.466
ENSG00000118412 E016 50.4521690 0.035495354 2.134478e-04 0.002824620 6 89854821 89854917 97 + 1.609 1.200 -1.417
ENSG00000118412 E017 43.8298712 0.048805585 9.905629e-04 0.009839750 6 89855470 89855544 75 + 1.550 1.151 -1.390
ENSG00000118412 E018 44.9498832 0.067956151 4.368156e-02 0.164314592 6 89857084 89857199 116 + 1.549 1.307 -0.837
ENSG00000118412 E019 0.4820342 0.022003614 9.276908e-01   6 89857200 89857349 150 + 0.147 0.000 -17.835
ENSG00000118412 E020 4.5899926 0.005477493 7.268409e-01 0.852323174 6 89861416 89861563 148 + 0.638 0.614 -0.107
ENSG00000118412 E021 475.1017185 0.070866413 1.134486e-02 0.063782647 6 89862126 89864371 2246 + 2.553 2.390 -0.545
ENSG00000118412 E022 529.8356660 1.953765726 4.516659e-01 0.666874670 6 89865953 89869082 3130 + 2.535 2.771 0.786
ENSG00000118412 E023 48.9748871 0.001091596 6.858625e-05 0.001090184 6 89871289 89871388 100 + 1.507 1.790 0.960
ENSG00000118412 E024 67.3581223 0.027958110 5.163557e-04 0.005825356 6 89873806 89874436 631 + 1.610 1.984 1.264