ENSG00000118276

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000237019 ENSG00000118276 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALT6 protein_coding protein_coding 8.52468 1.928192 18.16689 0.1102675 0.7970115 3.229322 0.5394825 0.0000000 1.024287 0.0000000 0.27123442 6.692492 0.03614583 0.0000000 0.05606667 0.05606667 2.655919e-02 3.416357e-07 FALSE TRUE
ENST00000306851 ENSG00000118276 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALT6 protein_coding protein_coding 8.52468 1.928192 18.16689 0.1102675 0.7970115 3.229322 4.5813948 1.6320688 9.308329 0.3666263 0.67409912 2.504557 0.70351667 0.8291333 0.51690000 -0.31223333 2.878776e-01 3.416357e-07 FALSE TRUE
ENST00000383131 ENSG00000118276 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALT6 protein_coding protein_coding 8.52468 1.928192 18.16689 0.1102675 0.7970115 3.229322 0.3168709 0.0000000 1.095732 0.0000000 0.06737692 6.788858 0.02054583 0.0000000 0.06066667 0.06066667 2.725176e-03 3.416357e-07 FALSE TRUE
MSTRG.15649.3 ENSG00000118276 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALT6 protein_coding   8.52468 1.928192 18.16689 0.1102675 0.7970115 3.229322 1.8020220 0.2045819 3.364745 0.2045819 1.13987119 3.975178 0.14043333 0.1197333 0.18050000 0.06076667 5.941095e-01 3.416357e-07 TRUE TRUE
MSTRG.15649.4 ENSG00000118276 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALT6 protein_coding   8.52468 1.928192 18.16689 0.1102675 0.7970115 3.229322 1.1447714 0.0000000 2.885917 0.0000000 0.32565233 8.177876 0.07278750 0.0000000 0.15796667 0.15796667 3.416357e-07 3.416357e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118276 E001 0.2735028 0.02744240 0.24160035   18 31622246 31622246 1 - 0.050 0.267 2.802
ENSG00000118276 E002 39.8444479 0.55141524 0.08256586 0.2498411 18 31622247 31622755 509 - 1.318 1.873 1.897
ENSG00000118276 E003 74.8880661 0.81752470 0.29660178 0.5371060 18 31622756 31622983 228 - 1.650 1.977 1.104
ENSG00000118276 E004 165.5549463 1.37656477 0.33412412 0.5727057 18 31622984 31624662 1679 - 1.972 2.369 1.330
ENSG00000118276 E005 122.0223621 1.29445772 0.60048995 0.7705395 18 31624663 31625484 822 - 1.897 2.029 0.441
ENSG00000118276 E006 27.0053578 0.52916137 0.51125061 0.7089256 18 31625485 31625543 59 - 1.261 1.397 0.474
ENSG00000118276 E007 62.7208086 0.37452266 0.45197068 0.6671085 18 31625544 31625761 218 - 1.610 1.765 0.525
ENSG00000118276 E008 51.3062131 0.00144844 0.18480263 0.4102449 18 31626283 31626384 102 - 1.548 1.595 0.161
ENSG00000118276 E009 0.1308682 0.03209467 0.08065917   18 31626989 31626998 10 - 0.000 0.267 12.818
ENSG00000118276 E010 54.1323196 0.02451565 0.01320793 0.0712859 18 31626999 31627121 123 - 1.581 1.492 -0.303
ENSG00000118276 E011 90.0089507 0.09092263 0.10624951 0.2927666 18 31630959 31631146 188 - 1.793 1.733 -0.205
ENSG00000118276 E012 67.0806190 0.08847258 0.13103306 0.3334396 18 31638644 31638760 117 - 1.667 1.617 -0.171
ENSG00000118276 E013 68.4935286 0.10781844 0.15267689 0.3661673 18 31645355 31645479 125 - 1.676 1.624 -0.177
ENSG00000118276 E014 0.1426347 0.03044206 1.00000000   18 31657975 31657975 1 - 0.050 0.000 -7.248
ENSG00000118276 E015 61.3805709 0.06514659 0.10585430 0.2920965 18 31657976 31658089 114 - 1.629 1.590 -0.130
ENSG00000118276 E016 1.6817128 0.48203527 0.30647203 0.5471141 18 31658090 31658464 375 - 0.239 0.660 2.280
ENSG00000118276 E017 58.8959893 0.05820388 0.03931381 0.1530229 18 31666256 31666372 117 - 1.617 1.530 -0.297
ENSG00000118276 E018 54.3239140 0.08755249 0.15096031 0.3636669 18 31684312 31684581 270 - 1.577 1.546 -0.106
ENSG00000118276 E019 3.3816930 2.70473822 1.00000000 1.0000000 18 31685730 31687915 2186 - 0.554 0.000 -11.649