ENSG00000118263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309446 ENSG00000118263 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF7 protein_coding protein_coding 0.5885857 0.6674812 0.7918199 0.1772135 0.1126059 0.2430973 0.21237575 0.24919256 0.37814858 0.06305381 0.04945118 0.58258472 0.40135000 0.37456667 0.4798667 0.10530000 0.7557899 0.0125833 FALSE TRUE
ENST00000412414 ENSG00000118263 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF7 protein_coding protein_coding 0.5885857 0.6674812 0.7918199 0.1772135 0.1126059 0.2430973 0.05480553 0.07624899 0.00000000 0.07624899 0.00000000 -3.10850759 0.13487083 0.21546667 0.0000000 -0.21546667 0.8943828 0.0125833 FALSE TRUE
ENST00000421199 ENSG00000118263 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF7 protein_coding protein_coding 0.5885857 0.6674812 0.7918199 0.1772135 0.1126059 0.2430973 0.10747399 0.00000000 0.23044670 0.00000000 0.05217424 4.58764524 0.16310417 0.00000000 0.3205333 0.32053333 0.0125833 0.0125833 FALSE TRUE
ENST00000423015 ENSG00000118263 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF7 protein_coding protein_coding 0.5885857 0.6674812 0.7918199 0.1772135 0.1126059 0.2430973 0.03287133 0.05275900 0.13459461 0.05275900 0.06930678 1.20411954 0.03947500 0.07743333 0.1492000 0.07176667 0.8253035 0.0125833 FALSE TRUE
ENST00000426163 ENSG00000118263 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF7 protein_coding protein_coding 0.5885857 0.6674812 0.7918199 0.1772135 0.1126059 0.2430973 0.05222034 0.05147063 0.04862999 0.05147063 0.04862999 -0.06825832 0.06768333 0.05320000 0.0504000 -0.00280000 1.0000000 0.0125833 FALSE FALSE
ENST00000451244 ENSG00000118263 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF7 protein_coding nonsense_mediated_decay 0.5885857 0.6674812 0.7918199 0.1772135 0.1126059 0.2430973 0.02251624 0.04025300 0.00000000 0.04025300 0.00000000 -2.32920964 0.03490833 0.05906667 0.0000000 -0.05906667 0.7941072 0.0125833   FALSE
ENST00000458272 ENSG00000118263 HEK293_OSMI2_6hA HEK293_TMG_6hB KLF7 protein_coding protein_coding 0.5885857 0.6674812 0.7918199 0.1772135 0.1126059 0.2430973 0.03702669 0.19755701 0.00000000 0.14581260 0.00000000 -4.37543577 0.04497917 0.22023333 0.0000000 -0.22023333 0.2731331 0.0125833 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118263 E001 42.2411728 0.002282881 0.02954045 0.12600798 2 207074137 207079089 4953 - 1.587 1.682 0.325
ENSG00000118263 E002 19.4090790 0.010814585 0.16215662 0.37998543 2 207079090 207080360 1271 - 1.358 1.245 -0.394
ENSG00000118263 E003 13.3098499 0.003350801 0.35800672 0.59416925 2 207080361 207081015 655 - 1.196 1.115 -0.291
ENSG00000118263 E004 6.9638071 0.018750585 0.28509982 0.52571126 2 207081016 207081264 249 - 0.838 0.975 0.518
ENSG00000118263 E005 4.2669849 0.007481350 0.06944440 0.22365364 2 207088458 207088581 124 - 0.596 0.845 1.029
ENSG00000118263 E006 2.3817978 0.010270202 0.10125893 0.28407802 2 207123774 207123897 124 - 0.393 0.656 1.264
ENSG00000118263 E007 1.3633072 0.016225386 0.79518818   2 207123898 207123975 78 - 0.338 0.384 0.269
ENSG00000118263 E008 3.4768021 0.008133366 0.26861226 0.50829060 2 207123976 207124168 193 - 0.709 0.542 -0.732
ENSG00000118263 E009 3.2047745 0.012748352 0.64305953 0.79886394 2 207124169 207124324 156 - 0.656 0.584 -0.317
ENSG00000118263 E010 1.3877679 0.015378759 0.47514568 0.68366238 2 207124325 207124343 19 - 0.441 0.314 -0.732
ENSG00000118263 E011 1.7628764 0.012905577 0.98672001 0.99522338 2 207124344 207124352 9 - 0.441 0.443 0.006
ENSG00000118263 E012 3.6983875 0.007762663 0.31466198 0.55482229 2 207124353 207124404 52 - 0.733 0.584 -0.638
ENSG00000118263 E013 0.0000000       2 207124405 207124408 4 -      
ENSG00000118263 E014 0.0000000       2 207134067 207134137 71 -      
ENSG00000118263 E015 0.1723744 0.031819531 0.41045998   2 207148982 207149200 219 - 0.000 0.132 9.424
ENSG00000118263 E016 7.2947035 0.086835389 0.91298642 0.95858945 2 207165467 207165706 240 - 0.917 0.903 -0.054
ENSG00000118263 E017 2.3751816 0.010319045 0.00892589 0.05349368 2 207165707 207165912 206 - 0.683 0.233 -2.431
ENSG00000118263 E018 2.3036052 0.010577327 0.20814189 0.43960451 2 207165913 207166186 274 - 0.595 0.383 -1.051
ENSG00000118263 E019 0.5587721 0.316952056 0.58052624   2 207166757 207166847 91 - 0.270 0.129 -1.311
ENSG00000118263 E020 0.0000000       2 207166994 207167139 146 -      
ENSG00000118263 E021 0.0000000       2 207167140 207167267 128 -