ENSG00000118260

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353267 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding protein_coding 11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 0.6987813 0.0000000 2.0105258 0.00000000 0.62985409 7.6585869 0.03994167 0.00000000 0.08963333 0.089633333 0.0002706882 0.0002706882 FALSE  
ENST00000418081 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding nonsense_mediated_decay 11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 0.7813889 0.1560479 0.9486480 0.03406667 0.14124227 2.5294013 0.06602917 0.04033333 0.04286667 0.002533333 1.0000000000 0.0002706882 TRUE  
ENST00000430624 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding protein_coding 11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 0.8723944 0.3358550 1.6441070 0.16812287 0.53824895 2.2578134 0.07066250 0.07976667 0.07700000 -0.002766667 0.9848031561 0.0002706882 FALSE  
ENST00000432329 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding protein_coding 11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 1.2371284 0.5191165 1.8814258 0.04732868 0.42929654 1.8378168 0.12211667 0.13323333 0.08453333 -0.048700000 0.5233441212 0.0002706882 FALSE  
ENST00000445803 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding protein_coding 11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 1.1196235 0.0000000 2.3224359 0.00000000 1.20479062 7.8656936 0.08871250 0.00000000 0.09876667 0.098766667 0.4960965652 0.0002706882 FALSE  
ENST00000448277 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding protein_coding 11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 3.3490904 1.5446351 5.8701998 0.43507326 1.34055613 1.9192891 0.30330417 0.38206667 0.25913333 -0.122933333 0.7190138661 0.0002706882 FALSE  
ENST00000455757 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding protein_coding 11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 0.3714096 0.3120549 0.4122641 0.10253909 0.11707186 0.3908388 0.05855833 0.08613333 0.01933333 -0.066800000 0.2444425298 0.0002706882 FALSE  
ENST00000494983 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding processed_transcript 11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 1.4523088 0.2735149 4.1188114 0.27351493 0.05023609 3.8642299 0.10041667 0.08393333 0.18680000 0.102866667 0.3993321258 0.0002706882 FALSE  
MSTRG.19877.4 ENSG00000118260 HEK293_OSMI2_6hA HEK293_TMG_6hB CREB1 protein_coding   11.82757 3.89595 22.19273 0.3361984 1.334375 2.506992 0.7909486 0.3136358 1.2842608 0.10760988 0.47865023 1.9996852 0.06883750 0.07720000 0.06083333 -0.016366667 0.9175872326 0.0002706882 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118260 E001 0.0000000       2 207529737 207529891 155 +      
ENSG00000118260 E002 0.1308682 0.0326491905 0.0946986709   2 207529892 207529922 31 + 0.000 0.221 10.840
ENSG00000118260 E003 0.7555370 0.0173312197 1.0000000000   2 207529923 207529931 9 + 0.211 0.221 0.084
ENSG00000118260 E004 2.3979564 0.0086455130 0.1848532518 0.410295894 2 207529932 207529939 8 + 0.409 0.636 1.085
ENSG00000118260 E005 9.6132184 0.0037032032 0.1397478520 0.347096842 2 207529940 207529961 22 + 0.897 1.066 0.626
ENSG00000118260 E006 26.8396105 0.0203094237 0.0169942641 0.085440728 2 207529962 207530018 57 + 1.293 1.512 0.759
ENSG00000118260 E007 35.8125580 0.0012821313 0.0298376011 0.126849019 2 207530019 207530071 53 + 1.436 1.575 0.475
ENSG00000118260 E008 42.7688934 0.0091953324 0.1999298063 0.429592258 2 207530072 207530103 32 + 1.526 1.611 0.289
ENSG00000118260 E009 43.0181958 0.0015684132 0.1953197206 0.423743337 2 207530104 207530134 31 + 1.530 1.604 0.253
ENSG00000118260 E010 0.0000000       2 207534602 207534683 82 +      
ENSG00000118260 E011 0.4820342 0.0213630535 0.6898862361   2 207550261 207550595 335 + 0.167 0.000 -12.512
ENSG00000118260 E012 70.6870340 0.0006058075 0.4491626469 0.665133267 2 207555628 207555749 122 + 1.750 1.779 0.097
ENSG00000118260 E013 0.0000000       2 207559122 207559170 49 +      
ENSG00000118260 E014 0.0000000       2 207559171 207559187 17 +      
ENSG00000118260 E015 0.0000000       2 207559188 207559225 38 +      
ENSG00000118260 E016 0.0000000       2 207559226 207559255 30 +      
ENSG00000118260 E017 68.3241119 0.0006118545 0.5656498553 0.747121155 2 207560226 207560313 88 + 1.752 1.712 -0.135
ENSG00000118260 E018 60.7792756 0.0008177412 0.8876186828 0.945415969 2 207560314 207560372 59 + 1.695 1.694 -0.003
ENSG00000118260 E019 13.5784967 0.0027717504 0.9800928836 0.991852130 2 207561119 207561160 42 + 1.078 1.066 -0.043
ENSG00000118260 E020 68.6195539 0.0010397275 0.6502439108 0.803741825 2 207567463 207567563 101 + 1.750 1.717 -0.113
ENSG00000118260 E021 0.6376527 0.0195143918 0.1610712576   2 207567564 207568150 587 + 0.118 0.367 2.086
ENSG00000118260 E022 73.7625484 0.0006561977 0.6121999872 0.778311433 2 207570179 207570321 143 + 1.773 1.789 0.054
ENSG00000118260 E023 0.3807181 0.0324609504 0.2835206514   2 207571734 207571777 44 + 0.063 0.222 2.087
ENSG00000118260 E024 38.8492582 0.0010043175 0.2799719806 0.520064285 2 207575272 207575285 14 + 1.488 1.551 0.216
ENSG00000118260 E025 76.2070852 0.0005343423 0.1295832113 0.331159479 2 207575286 207575454 169 + 1.774 1.838 0.215
ENSG00000118260 E026 1.9093557 0.0102906907 0.0524482169 0.185350659 2 207576631 207576635 5 + 0.459 0.000 -14.404
ENSG00000118260 E027 2.6814608 0.0087448934 0.1278736511 0.328476155 2 207576636 207576693 58 + 0.545 0.221 -1.916
ENSG00000118260 E028 5.3199508 0.0244523002 0.2827281018 0.523162204 2 207577110 207577224 115 + 0.679 0.842 0.656
ENSG00000118260 E029 74.2983726 0.0017817361 0.0269424979 0.118138312 2 207577505 207577655 151 + 1.759 1.861 0.345
ENSG00000118260 E030 4.3418828 0.1017959462 0.0141486947 0.074948494 2 207577656 207578065 410 + 0.506 0.961 1.885
ENSG00000118260 E031 74.9520975 0.0455195535 0.2713770108 0.511323053 2 207596914 207597164 251 + 1.763 1.851 0.296
ENSG00000118260 E032 53.8506890 0.0022958015 0.8377952450 0.918199842 2 207597165 207597326 162 + 1.643 1.645 0.006
ENSG00000118260 E033 29.1770268 0.0013769781 0.7785242936 0.883860113 2 207597327 207597347 21 + 1.392 1.360 -0.110
ENSG00000118260 E034 59.2336783 0.0007815770 0.7637394553 0.874906577 2 207597348 207597483 136 + 1.691 1.664 -0.090
ENSG00000118260 E035 129.9780316 0.0003641512 0.0028822916 0.022699539 2 207597484 207599079 1596 + 2.040 1.911 -0.435
ENSG00000118260 E036 439.1428398 0.0038931124 0.0007910431 0.008206812 2 207599080 207605988 6909 + 2.561 2.451 -0.368