ENSG00000118193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367350 ENSG00000118193 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF14 protein_coding protein_coding 5.925573 2.31156 12.02956 0.2241671 0.4122294 2.374616 1.96856981 0.22716116 4.1628337 0.11360212 0.4801498 4.137088 0.26457917 0.08986667 0.34470000 0.25483333 0.277727099 0.004008171 FALSE TRUE
ENST00000614960 ENSG00000118193 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF14 protein_coding protein_coding 5.925573 2.31156 12.02956 0.2241671 0.4122294 2.374616 2.12704765 1.63821181 4.8715315 0.16400459 0.2731485 1.566432 0.31696250 0.71140000 0.40590000 -0.30550000 0.004008171 0.004008171 FALSE TRUE
MSTRG.2809.1 ENSG00000118193 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF14 protein_coding   5.925573 2.31156 12.02956 0.2241671 0.4122294 2.374616 0.37839480 0.00000000 0.2277505 0.00000000 0.2277505 4.571377 0.24377500 0.00000000 0.02033333 0.02033333 1.000000000 0.004008171 FALSE TRUE
MSTRG.2809.11 ENSG00000118193 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF14 protein_coding   5.925573 2.31156 12.02956 0.2241671 0.4122294 2.374616 0.36335687 0.02473258 0.9298033 0.02473258 0.4704849 4.757997 0.03940417 0.01320000 0.07476667 0.06156667 0.764547640 0.004008171 FALSE TRUE
MSTRG.2809.12 ENSG00000118193 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF14 protein_coding   5.925573 2.31156 12.02956 0.2241671 0.4122294 2.374616 0.25511216 0.00000000 0.7253830 0.00000000 0.2909199 6.200424 0.02615000 0.00000000 0.06066667 0.06066667 0.072466996 0.004008171 FALSE TRUE
MSTRG.2809.4 ENSG00000118193 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF14 protein_coding   5.925573 2.31156 12.02956 0.2241671 0.4122294 2.374616 0.05289183 0.31604490 0.0000000 0.15851972 0.0000000 -5.026999 0.01950417 0.14356667 0.00000000 -0.14356667 0.067720877 0.004008171 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118193 E001 0.000000       1 200551497 200551499 3 -      
ENSG00000118193 E002 34.874068 0.7043640248 1.871582e-01 0.4132485042 1 200551500 200551873 374 - 1.325 1.760 1.489
ENSG00000118193 E003 68.084366 0.9045342224 1.899275e-01 0.4168429159 1 200551874 200552201 328 - 1.589 2.073 1.634
ENSG00000118193 E004 134.062246 1.4326331139 3.607788e-01 0.5962642113 1 200552202 200553378 1177 - 1.914 2.301 1.295
ENSG00000118193 E005 22.641189 0.6121880642 2.719939e-01 0.5118607474 1 200553379 200553409 31 - 1.181 1.511 1.148
ENSG00000118193 E006 20.553620 0.5489076049 2.202211e-01 0.4537894608 1 200553410 200553427 18 - 1.136 1.486 1.226
ENSG00000118193 E007 17.432095 0.4942877088 2.104631e-01 0.4423679517 1 200553428 200553429 2 - 1.069 1.419 1.234
ENSG00000118193 E008 20.165231 0.5086252323 1.309898e-01 0.3333609908 1 200553430 200553449 20 - 1.094 1.542 1.568
ENSG00000118193 E009 45.706764 0.7994868410 2.176492e-01 0.4505948466 1 200553450 200553552 103 - 1.444 1.863 1.423
ENSG00000118193 E010 60.915975 0.9044920403 2.808811e-01 0.5211243861 1 200553553 200553767 215 - 1.583 1.951 1.242
ENSG00000118193 E011 45.658095 0.0312670951 7.275134e-03 0.0459578600 1 200554468 200554606 139 - 1.474 1.811 1.148
ENSG00000118193 E012 40.269738 0.0011715273 5.787134e-02 0.1980293551 1 200555380 200555454 75 - 1.459 1.668 0.716
ENSG00000118193 E013 49.909803 0.0008365866 3.066412e-01 0.5472741310 1 200559330 200559452 123 - 1.562 1.712 0.510
ENSG00000118193 E014 59.426974 0.0006622650 6.647428e-01 0.8128382403 1 200560722 200560880 159 - 1.644 1.758 0.385
ENSG00000118193 E015 66.904422 0.0006537213 5.546210e-01 0.7395361648 1 200565069 200565253 185 - 1.705 1.763 0.198
ENSG00000118193 E016 75.151524 0.0025259901 8.696103e-01 0.9356618529 1 200565445 200565669 225 - 1.744 1.845 0.341
ENSG00000118193 E017 54.110500 0.0237065388 4.985101e-01 0.6997668214 1 200569911 200570005 95 - 1.617 1.647 0.099
ENSG00000118193 E018 61.380317 0.0227925038 9.347450e-01 0.9695879656 1 200575591 200575691 101 - 1.656 1.755 0.334
ENSG00000118193 E019 61.638603 0.0087951153 3.455006e-01 0.5831005672 1 200580254 200580383 130 - 1.673 1.700 0.090
ENSG00000118193 E020 45.497171 0.0014585465 3.588205e-01 0.5948478663 1 200581201 200581294 94 - 1.520 1.668 0.504
ENSG00000118193 E021 48.044690 0.0170195089 9.134559e-01 0.9588149672 1 200586101 200586227 127 - 1.554 1.663 0.372
ENSG00000118193 E022 57.151290 0.0130328173 2.066777e-01 0.4377243418 1 200589217 200589369 153 - 1.649 1.644 -0.016
ENSG00000118193 E023 58.879754 0.0112797209 2.266439e-01 0.4613376516 1 200590125 200590272 148 - 1.659 1.660 0.005
ENSG00000118193 E024 60.323828 0.0269010676 1.103974e-01 0.2996539938 1 200592080 200592240 161 - 1.680 1.621 -0.200
ENSG00000118193 E025 39.994416 0.0050154026 5.230462e-02 0.1850497820 1 200593667 200593769 103 - 1.508 1.447 -0.210
ENSG00000118193 E026 62.991478 0.0091657059 9.714499e-02 0.2767710052 1 200598237 200598421 185 - 1.693 1.663 -0.104
ENSG00000118193 E027 41.767829 0.0051488983 8.391668e-02 0.2526098207 1 200600050 200600113 64 - 1.522 1.480 -0.144
ENSG00000118193 E028 59.375746 0.0222311202 1.360124e-01 0.3413637466 1 200600356 200600503 148 - 1.669 1.623 -0.158
ENSG00000118193 E029 61.840767 0.0286963064 8.169917e-02 0.2482029669 1 200601896 200602068 173 - 1.693 1.612 -0.276
ENSG00000118193 E030 47.064542 0.0030227112 2.752683e-03 0.0218852491 1 200603226 200603341 116 - 1.586 1.459 -0.436
ENSG00000118193 E031 50.479585 0.0081502130 9.358207e-02 0.2703844563 1 200603839 200603955 117 - 1.602 1.570 -0.110
ENSG00000118193 E032 47.276556 0.0137269799 2.973444e-03 0.0232357411 1 200605283 200605390 108 - 1.594 1.422 -0.589
ENSG00000118193 E033 28.634254 0.0042558952 6.357619e-03 0.0414960728 1 200605864 200605894 31 - 1.384 1.221 -0.570
ENSG00000118193 E034 34.688223 0.0084574868 5.380499e-04 0.0060193183 1 200606746 200606798 53 - 1.472 1.238 -0.813
ENSG00000118193 E035 38.758803 0.0102309432 6.399923e-02 0.2116684850 1 200608830 200608928 99 - 1.493 1.425 -0.236
ENSG00000118193 E036 37.428629 0.0089077433 4.368992e-02 0.1643384830 1 200614318 200614405 88 - 1.483 1.400 -0.283
ENSG00000118193 E037 62.593933 0.0137338326 2.980601e-04 0.0037104138 1 200615355 200615609 255 - 1.719 1.513 -0.700
ENSG00000118193 E038 43.200166 0.0014686977 9.025748e-02 0.2642426235 1 200617612 200617745 134 - 1.537 1.509 -0.096
ENSG00000118193 E039 89.836794 0.0051081999 4.544208e-04 0.0052611884 1 200617746 200618179 434 - 1.860 1.745 -0.387
ENSG00000118193 E040 67.179050 0.0034309697 1.637969e-05 0.0003222857 1 200618180 200618467 288 - 1.743 1.547 -0.664
ENSG00000118193 E041 36.402318 0.0222298117 4.026817e-02 0.1554054672 1 200618468 200618551 84 - 1.472 1.342 -0.452
ENSG00000118193 E042 40.266704 0.0220261207 5.422715e-01 0.7306830765 1 200618552 200618652 101 - 1.490 1.517 0.094
ENSG00000118193 E043 36.862419 0.0009845846 1.101207e-01 0.2992115428 1 200618653 200618838 186 - 1.467 1.437 -0.104
ENSG00000118193 E044 7.786303 0.0112033496 4.903453e-01 0.6942334266 1 200619552 200619674 123 - 0.852 0.826 -0.101
ENSG00000118193 E045 23.548357 0.0030608352 1.888523e-01 0.4155571737 1 200620411 200620541 131 - 1.291 1.257 -0.119
ENSG00000118193 E046 13.010318 0.0197629826 6.504215e-01 0.8038067375 1 200620542 200620557 16 - 1.034 1.065 0.116
ENSG00000118193 E047 17.460885 0.0131502865 4.553780e-01 0.6697816292 1 200620558 200620711 154 - 1.155 1.161 0.020
ENSG00000118193 E048 7.618675 0.0037116935 2.566103e-02 0.1142408950 1 200620712 200620795 84 - 0.871 0.586 -1.173