ENSG00000118046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326873 ENSG00000118046 HEK293_OSMI2_6hA HEK293_TMG_6hB STK11 protein_coding protein_coding 57.36694 86.3822 32.17029 13.60198 1.028353 -1.424724 32.840099 54.486624 12.343625 12.1646742 0.5121403 -2.1412324 0.53488333 0.61486667 0.3844667 -0.23040000 0.03603571 0.007214668 FALSE TRUE
ENST00000586358 ENSG00000118046 HEK293_OSMI2_6hA HEK293_TMG_6hB STK11 protein_coding retained_intron 57.36694 86.3822 32.17029 13.60198 1.028353 -1.424724 12.192771 14.798055 9.869828 1.8163305 0.9033875 -0.5838243 0.23085417 0.17560000 0.3056000 0.13000000 0.03865456 0.007214668 TRUE FALSE
ENST00000591133 ENSG00000118046 HEK293_OSMI2_6hA HEK293_TMG_6hB STK11 protein_coding retained_intron 57.36694 86.3822 32.17029 13.60198 1.028353 -1.424724 4.172003 5.598787 3.217603 0.1151191 0.2177386 -0.7972257 0.07842917 0.06893333 0.1005000 0.03156667 0.56364674 0.007214668 TRUE TRUE
ENST00000652231 ENSG00000118046 HEK293_OSMI2_6hA HEK293_TMG_6hB STK11 protein_coding protein_coding 57.36694 86.3822 32.17029 13.60198 1.028353 -1.424724 2.996184 4.618853 2.405790 0.3940181 0.1391360 -0.9381596 0.05702083 0.05786667 0.0749000 0.01703333 0.76487634 0.007214668 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118046 E001 0.000000       19 1177558 1177811 254 +      
ENSG00000118046 E002 0.000000       19 1179240 1179333 94 +      
ENSG00000118046 E003 0.000000       19 1189409 1189659 251 +      
ENSG00000118046 E004 1.672091 0.0133268425 8.896649e-01 9.465139e-01 19 1205468 1205777 310 + 0.360 0.389 0.170
ENSG00000118046 E005 19.905259 0.2271984517 4.429472e-02 1.658348e-01 19 1205778 1206185 408 + 0.848 1.284 1.592
ENSG00000118046 E006 595.716366 0.0002174011 2.876965e-06 7.167856e-05 19 1206186 1206815 630 + 2.608 2.698 0.300
ENSG00000118046 E007 182.007205 0.0013773296 8.193371e-01 9.076990e-01 19 1206816 1206823 8 + 2.175 2.164 -0.038
ENSG00000118046 E008 349.514910 0.0008684875 4.070469e-01 6.337744e-01 19 1206824 1206868 45 + 2.468 2.444 -0.080
ENSG00000118046 E009 643.559889 0.0001292005 2.009326e-02 9.619963e-02 19 1206869 1207090 222 + 2.745 2.707 -0.129
ENSG00000118046 E010 589.594003 0.0008144284 3.456459e-05 6.087806e-04 19 1207091 1207203 113 + 2.746 2.655 -0.302
ENSG00000118046 E011 6.193678 0.0044675196 9.672585e-03 5.671664e-02 19 1216268 1216398 131 + 1.027 0.688 -1.316
ENSG00000118046 E012 559.112691 0.0018096781 9.954816e-07 2.830331e-05 19 1218417 1218500 84 + 2.753 2.621 -0.440
ENSG00000118046 E013 527.156967 0.0028309139 1.287585e-01 3.298320e-01 19 1219324 1219413 90 + 2.667 2.614 -0.175
ENSG00000118046 E014 57.458024 0.0413648798 3.318156e-02 1.365331e-01 19 1220013 1220372 360 + 1.854 1.608 -0.831
ENSG00000118046 E015 530.463023 0.0003524571 2.860900e-01 5.267594e-01 19 1220373 1220505 133 + 2.612 2.633 0.070
ENSG00000118046 E016 39.553448 0.0040935576 3.802113e-01 6.123637e-01 19 1220506 1220580 75 + 1.458 1.521 0.217
ENSG00000118046 E017 554.939232 0.0002487807 1.895387e-01 4.163609e-01 19 1220581 1220717 137 + 2.629 2.655 0.088
ENSG00000118046 E018 555.625561 0.0019355448 5.483514e-01 7.351625e-01 19 1221213 1221340 128 + 2.661 2.645 -0.053
ENSG00000118046 E019 46.086966 0.0552083469 4.062636e-02 1.563770e-01 19 1221341 1221948 608 + 1.775 1.509 -0.905
ENSG00000118046 E020 404.986182 0.0016526152 8.138291e-01 9.045773e-01 19 1221949 1222006 58 + 2.505 2.513 0.027
ENSG00000118046 E021 630.646500 0.0017073693 4.319580e-01 6.527197e-01 19 1222985 1223147 163 + 2.718 2.700 -0.061
ENSG00000118046 E022 355.050876 0.0015773983 4.243126e-01 6.468192e-01 19 1223148 1223172 25 + 2.474 2.452 -0.072
ENSG00000118046 E023 270.167825 0.0458709674 1.744424e-01 3.964446e-01 19 1223638 1226453 2816 + 2.451 2.300 -0.502
ENSG00000118046 E024 248.797355 0.0002467567 5.414987e-01 7.301265e-01 19 1226454 1226458 5 + 2.317 2.302 -0.052
ENSG00000118046 E025 557.729055 0.0032192854 2.267254e-03 1.884270e-02 19 1226459 1226663 205 + 2.564 2.668 0.345
ENSG00000118046 E026 32.061551 0.0846304618 2.862544e-01 5.269184e-01 19 1226664 1227592 929 + 1.550 1.385 -0.567
ENSG00000118046 E027 602.039793 0.0035917470 2.480438e-22 9.617248e-20 19 1227593 1228431 839 + 2.381 2.733 1.172