ENSG00000118007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000383202 ENSG00000118007 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG1 protein_coding protein_coding 12.52916 2.669918 22.95559 0.3965539 0.852202 3.099213 7.5317660 2.273154 12.735050 0.4033373 0.0967641 2.480837 0.70517083 0.8435 0.5561000 -0.2874000 4.764934e-03 3.396597e-13 FALSE TRUE
MSTRG.23761.5 ENSG00000118007 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG1 protein_coding   12.52916 2.669918 22.95559 0.3965539 0.852202 3.099213 0.8292739 0.000000 1.704902 0.0000000 0.0702648 7.421983 0.04193333 0.0000 0.0747000 0.0747000 5.670387e-05 3.396597e-13 FALSE TRUE
MSTRG.23761.7 ENSG00000118007 HEK293_OSMI2_6hA HEK293_TMG_6hB STAG1 protein_coding   12.52916 2.669918 22.95559 0.3965539 0.852202 3.099213 3.0813670 0.000000 6.831061 0.0000000 0.7599321 9.418076 0.13899583 0.0000 0.2958667 0.2958667 3.396597e-13 3.396597e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000118007 E001 117.8294451 1.4569444321 0.2570775090 0.495889312 3 136336236 136337156 921 - 1.781 2.320 1.806
ENSG00000118007 E002 37.9826350 0.8328475931 0.1506174944 0.363177729 3 136337157 136337387 231 - 1.305 1.833 1.806
ENSG00000118007 E003 99.9413723 0.2984331651 0.0912932671 0.266061961 3 136337388 136337947 560 - 1.751 2.155 1.356
ENSG00000118007 E004 88.1018505 0.0095954508 0.0016673166 0.014795878 3 136337948 136338094 147 - 1.727 1.990 0.885
ENSG00000118007 E005 76.6449862 0.0162228966 0.2370811611 0.473189879 3 136338095 136338169 75 - 1.689 1.840 0.512
ENSG00000118007 E006 92.8560223 0.0013649675 0.8867469416 0.944991251 3 136338170 136338277 108 - 1.787 1.850 0.215
ENSG00000118007 E007 89.2903817 0.0004212539 0.1814562090 0.405908512 3 136338370 136338450 81 - 1.762 1.886 0.417
ENSG00000118007 E008 111.3730934 0.0003904511 0.9986789690 1.000000000 3 136340491 136340605 115 - 1.867 1.923 0.188
ENSG00000118007 E009 107.8728285 0.0003840750 0.8001366359 0.896402314 3 136341441 136341551 111 - 1.856 1.900 0.147
ENSG00000118007 E010 118.5267505 0.0006277547 0.7542766979 0.869279376 3 136343832 136344006 175 - 1.899 1.940 0.140
ENSG00000118007 E011 2.1583978 0.0130766883 0.8656838941 0.933544704 3 136348789 136349157 369 - 0.367 0.436 0.378
ENSG00000118007 E012 126.8239861 0.0003506206 0.1163561185 0.309717008 3 136349158 136349363 206 - 1.935 1.918 -0.055
ENSG00000118007 E013 95.7560886 0.0004053295 0.0447999863 0.167133149 3 136357720 136357848 129 - 1.816 1.763 -0.179
ENSG00000118007 E014 80.7134921 0.0004873244 0.4306260264 0.651625289 3 136359148 136359296 149 - 1.724 1.823 0.333
ENSG00000118007 E015 62.0466650 0.0199378164 0.6611479066 0.810634579 3 136363366 136363467 102 - 1.622 1.654 0.110
ENSG00000118007 E016 76.9473485 0.0013211613 0.2908374784 0.531456320 3 136366943 136367082 140 - 1.716 1.708 -0.028
ENSG00000118007 E017 96.3175653 0.0019740258 0.9473246599 0.975977172 3 136369108 136369282 175 - 1.802 1.861 0.198
ENSG00000118007 E018 77.8672619 0.0006192240 0.9970804381 1.000000000 3 136377660 136377752 93 - 1.714 1.769 0.186
ENSG00000118007 E019 73.7348611 0.0005203196 0.0562660240 0.194242891 3 136398749 136398829 81 - 1.707 1.644 -0.213
ENSG00000118007 E020 0.3040503 0.0244411696 1.0000000000   3 136417558 136417884 327 - 0.094 0.000 -9.190
ENSG00000118007 E021 78.7246651 0.0005333170 0.2151771157 0.447747581 3 136417885 136417972 88 - 1.731 1.715 -0.056
ENSG00000118007 E022 68.6081976 0.0042886989 0.2784404716 0.518550645 3 136421093 136421163 71 - 1.670 1.652 -0.061
ENSG00000118007 E023 107.2927459 0.0034028248 0.1199336526 0.315740814 3 136422410 136422613 204 - 1.861 1.828 -0.112
ENSG00000118007 E024 62.6780819 0.0014578257 0.3063761927 0.547041818 3 136422768 136422857 90 - 1.631 1.618 -0.044
ENSG00000118007 E025 34.7694505 0.0019183292 0.2388998271 0.475324513 3 136422952 136422956 5 - 1.388 1.336 -0.178
ENSG00000118007 E026 71.1284179 0.0006063191 0.0569467618 0.195915601 3 136422957 136423044 88 - 1.692 1.627 -0.219
ENSG00000118007 E027 69.6960146 0.0009386046 0.5611464568 0.744091934 3 136433556 136433659 104 - 1.672 1.692 0.069
ENSG00000118007 E028 90.1023066 0.0198872613 0.1516599985 0.364739963 3 136443287 136443404 118 - 1.792 1.739 -0.177
ENSG00000118007 E029 98.1078158 0.0044714856 0.0069475166 0.044388567 3 136452033 136452147 115 - 1.833 1.720 -0.383
ENSG00000118007 E030 74.1665138 0.0011822945 0.0206005184 0.098023027 3 136464881 136464988 108 - 1.711 1.618 -0.314
ENSG00000118007 E031 57.3133139 0.0011700403 0.0011232356 0.010844300 3 136472413 136472492 80 - 1.610 1.415 -0.667
ENSG00000118007 E032 67.3370959 0.0026158954 0.0168608162 0.084935762 3 136473539 136473637 99 - 1.672 1.560 -0.382
ENSG00000118007 E033 79.1159792 0.0007618589 0.0001779242 0.002424394 3 136477289 136477412 124 - 1.748 1.560 -0.636
ENSG00000118007 E034 0.8192208 0.1288123888 0.5843357545   3 136499766 136500222 457 - 0.206 0.000 -10.520
ENSG00000118007 E035 72.9322863 0.0050364346 0.0005397923 0.006034890 3 136500223 136500296 74 - 1.713 1.505 -0.707
ENSG00000118007 E036 94.6021451 0.0004894808 0.0034569220 0.026084816 3 136502628 136502779 152 - 1.817 1.708 -0.369
ENSG00000118007 E037 1.5170433 0.0505496885 0.2038393353 0.434423566 3 136518043 136518247 205 - 0.265 0.554 1.619
ENSG00000118007 E038 4.2414154 0.0063364355 0.2400530135 0.476688134 3 136518248 136518415 168 - 0.548 0.790 1.030
ENSG00000118007 E039 98.4317271 0.0004476149 0.0167374603 0.084499843 3 136521213 136521417 205 - 1.830 1.756 -0.250
ENSG00000118007 E040 60.3899483 0.0007939371 0.0706120337 0.225936080 3 136542119 136542195 77 - 1.620 1.550 -0.238
ENSG00000118007 E041 58.8085225 0.0006916773 0.0086390774 0.052219756 3 136568765 136568861 97 - 1.616 1.482 -0.460
ENSG00000118007 E042 0.9452873 0.0163580632 0.4271122945   3 136586802 136586926 125 - 0.237 0.000 -10.775
ENSG00000118007 E043 3.4996139 0.1919515689 0.0001043039 0.001549110 3 136591445 136591549 105 - 0.235 1.140 4.158
ENSG00000118007 E044 82.3841248 0.0009325800 0.6650775278 0.813112998 3 136604309 136604473 165 - 1.733 1.812 0.267
ENSG00000118007 E045 56.3112620 0.0007282025 0.5945613416 0.766708186 3 136623146 136623248 103 - 1.572 1.661 0.304
ENSG00000118007 E046 51.3612718 0.0153057108 0.9280203183 0.966035292 3 136630870 136630981 112 - 1.540 1.581 0.141
ENSG00000118007 E047 0.0000000       3 136671637 136671669 33 -      
ENSG00000118007 E048 37.1267237 0.0012850301 0.7255334889 0.851460913 3 136752195 136752403 209 - 1.400 1.482 0.281