ENSG00000117724

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366955 ENSG00000117724 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPF protein_coding protein_coding 32.68856 37.0259 46.71198 6.887071 1.146837 0.3351772 18.359496 11.515011 34.82697744 1.773625 1.31855310 1.5958514 0.5119000 0.32123333 0.7477666667 0.42653333 2.699297e-05 2.699297e-05 FALSE TRUE
ENST00000469862 ENSG00000117724 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPF protein_coding processed_transcript 32.68856 37.0259 46.71198 6.887071 1.146837 0.3351772 12.575504 22.505981 11.31830427 4.858678 2.33544327 -0.9910174 0.4183042 0.60056667 0.2402000000 -0.36036667 8.525155e-05 2.699297e-05 FALSE FALSE
MSTRG.3049.4 ENSG00000117724 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPF protein_coding   32.68856 37.0259 46.71198 6.887071 1.146837 0.3351772 1.356179 2.617361 0.03969734 1.181095 0.03969734 -5.7243021 0.0563625 0.06253333 0.0008666667 -0.06166667 8.179221e-04 2.699297e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117724 E001 18.2068305 0.1535669032 2.029878e-02 9.692948e-02 1 214603195 214603252 58 + 1.416 0.911 -1.810
ENSG00000117724 E002 46.9247054 0.1046300550 4.602397e-03 3.248695e-02 1 214603253 214603321 69 + 1.810 1.319 -1.679
ENSG00000117724 E003 0.3447487 0.7085712571 2.467911e-01   1 214603484 214603648 165 + 0.000 0.259 12.312
ENSG00000117724 E004 115.9331009 0.1000881157 2.441183e-04 3.154535e-03 1 214613714 214613916 203 + 2.213 1.628 -1.971
ENSG00000117724 E005 136.6705447 0.0927581926 2.391848e-05 4.447994e-04 1 214614832 214615028 197 + 2.293 1.643 -2.186
ENSG00000117724 E006 0.3336024 0.0244411696 1.056661e-01   1 214615029 214615190 162 + 0.000 0.255 12.277
ENSG00000117724 E007 91.5209938 0.0990130151 3.791370e-05 6.586823e-04 1 214618573 214618694 122 + 2.124 1.448 -2.286
ENSG00000117724 E008 76.4105203 0.0914746268 3.099005e-05 5.553846e-04 1 214619129 214619220 92 + 2.046 1.372 -2.290
ENSG00000117724 E009 159.3294389 0.0716484479 5.089566e-05 8.448928e-04 1 214620655 214620946 292 + 2.346 1.790 -1.863
ENSG00000117724 E010 149.3352873 0.0881797065 2.112563e-04 2.798891e-03 1 214622079 214622281 203 + 2.318 1.760 -1.871
ENSG00000117724 E011 110.7987478 0.0877725868 5.121412e-04 5.787806e-03 1 214629046 214629171 126 + 2.183 1.668 -1.733
ENSG00000117724 E012 109.3571282 0.1098878020 8.377021e-04 8.590127e-03 1 214630534 214630662 129 + 2.180 1.648 -1.793
ENSG00000117724 E013 110.1558651 0.1063332041 8.652741e-04 8.813786e-03 1 214632480 214632602 123 + 2.184 1.646 -1.811
ENSG00000117724 E014 100.8478991 0.0289859737 2.848606e-07 9.415315e-06 1 214637866 214638001 136 + 2.139 1.652 -1.640
ENSG00000117724 E015 709.1234225 0.5561862923 9.145815e-01 9.593818e-01 1 214639921 214641812 1892 + 2.942 2.634 -1.023
ENSG00000117724 E016 339.1499370 1.5915661850 7.531896e-01 8.686576e-01 1 214641813 214642437 625 + 2.577 2.429 -0.492
ENSG00000117724 E017 429.7897107 1.6419522932 6.586488e-01 8.091329e-01 1 214642438 214643324 887 + 2.646 2.593 -0.179
ENSG00000117724 E018 565.3060443 1.7248028333 6.428093e-01 7.986836e-01 1 214644557 214645579 1023 + 2.755 2.728 -0.090
ENSG00000117724 E019 1246.2380691 0.9877379854 4.006232e-01 6.288023e-01 1 214645580 214647400 1821 + 3.041 3.149 0.358
ENSG00000117724 E020 323.0883912 0.0003212399 2.417751e-17 4.977217e-15 1 214648675 214648827 153 + 2.441 2.598 0.524
ENSG00000117724 E021 370.2662919 0.0373347044 3.062489e-01 5.469126e-01 1 214651710 214651886 177 + 2.515 2.622 0.354
ENSG00000117724 E022 179.7495541 0.0556061806 8.966949e-01 9.501785e-01 1 214652828 214652857 30 + 2.237 2.264 0.090
ENSG00000117724 E023 277.8469854 0.0484081736 3.890720e-01 6.197819e-01 1 214652858 214652989 132 + 2.389 2.499 0.368
ENSG00000117724 E024 8.5137058 0.3799421894 5.986257e-01 7.693445e-01 1 214653485 214654419 935 + 1.002 0.917 -0.318
ENSG00000117724 E025 2.0528772 0.1277315799 5.307089e-01 7.225238e-01 1 214655148 214655240 93 + 0.412 0.536 0.622
ENSG00000117724 E026 406.4848855 0.0479363861 1.705791e-01 3.912288e-01 1 214655241 214655403 163 + 2.532 2.689 0.523
ENSG00000117724 E027 751.6991400 0.0606313325 1.106114e-01 3.000026e-01 1 214656933 214657409 477 + 2.780 2.973 0.640
ENSG00000117724 E028 0.1723744 0.0625105850 3.174675e-01   1 214657410 214657410 1 + 0.000 0.146 11.279
ENSG00000117724 E029 358.0917075 0.0365805308 9.260697e-03 5.495420e-02 1 214658850 214659028 179 + 2.426 2.681 0.847
ENSG00000117724 E030 606.2857485 0.0501029561 6.011398e-02 2.030920e-01 1 214663591 214664571 981 + 2.677 2.889 0.707