ENSG00000117713

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324856 ENSG00000117713 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID1A protein_coding protein_coding 22.62572 35.77026 19.03502 3.721059 0.472032 -0.9097504 3.0296446 4.944407 2.195413 0.6586176 0.1364360 -1.16766383 0.14539583 0.1387333 0.1158000 -0.02293333 7.980827e-01 7.8209e-15 FALSE TRUE
ENST00000457599 ENSG00000117713 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID1A protein_coding protein_coding 22.62572 35.77026 19.03502 3.721059 0.472032 -0.9097504 0.6604012 0.000000 1.179802 0.0000000 0.2036431 6.89457822 0.03504583 0.0000000 0.0617000 0.06170000 7.820900e-15 7.8209e-15 FALSE TRUE
ENST00000466382 ENSG00000117713 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID1A protein_coding nonsense_mediated_decay 22.62572 35.77026 19.03502 3.721059 0.472032 -0.9097504 5.9196452 12.011877 1.426310 2.8171963 0.8122868 -3.06522345 0.22343333 0.3259667 0.0761000 -0.24986667 4.639743e-01 7.8209e-15 FALSE TRUE
ENST00000636219 ENSG00000117713 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID1A protein_coding protein_coding 22.62572 35.77026 19.03502 3.721059 0.472032 -0.9097504 7.7598868 10.677577 10.321307 1.2143611 0.9445692 -0.04891202 0.36963333 0.3010000 0.5407000 0.23970000 9.834984e-03 7.8209e-15 FALSE TRUE
MSTRG.618.11 ENSG00000117713 HEK293_OSMI2_6hA HEK293_TMG_6hB ARID1A protein_coding   22.62572 35.77026 19.03502 3.721059 0.472032 -0.9097504 2.5900416 4.890845 2.046887 0.8743542 0.1940302 -1.25256766 0.11101250 0.1361667 0.1078667 -0.02830000 7.825921e-01 7.8209e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117713 E001 0.1426347 0.0319892815 2.626469e-01   1 26693236 26693617 382 + 0.153 0.000 -10.493
ENSG00000117713 E002 3.9295061 0.0067945136 5.562127e-02 1.927512e-01 1 26696015 26696031 17 + 0.813 0.569 -1.025
ENSG00000117713 E003 8.8184173 0.0215162868 1.288949e-02 6.999656e-02 1 26696032 26696050 19 + 1.137 0.877 -0.961
ENSG00000117713 E004 14.9027352 0.0220944952 7.421045e-01 8.617014e-01 1 26696051 26696063 13 + 1.188 1.202 0.052
ENSG00000117713 E005 18.3373277 0.0219968653 9.251478e-01 9.648380e-01 1 26696064 26696100 37 + 1.253 1.295 0.147
ENSG00000117713 E006 34.0998617 0.0219158118 2.663783e-01 5.058870e-01 1 26696101 26696403 303 + 1.428 1.589 0.551
ENSG00000117713 E007 102.8104892 0.0024842290 2.256858e-01 4.601534e-01 1 26696404 26697540 1137 + 1.940 2.035 0.317
ENSG00000117713 E008 0.4929928 0.0217681645 2.648716e-01   1 26727708 26727873 166 + 0.266 0.096 -1.783
ENSG00000117713 E009 0.2735028 0.0258628859 6.398475e-01   1 26728912 26729650 739 + 0.153 0.095 -0.785
ENSG00000117713 E010 21.0318783 0.0019674039 7.616795e-02 2.370884e-01 1 26729651 26729656 6 + 1.385 1.289 -0.338
ENSG00000117713 E011 65.9229707 0.0007325234 8.262811e-02 2.499582e-01 1 26729657 26729863 207 + 1.837 1.800 -0.125
ENSG00000117713 E012 173.2257978 0.0022076777 4.572460e-02 1.693253e-01 1 26731152 26731604 453 + 2.247 2.219 -0.094
ENSG00000117713 E013 111.7423008 0.0004802770 6.439284e-06 1.433961e-04 1 26732676 26732792 117 + 2.109 1.994 -0.383
ENSG00000117713 E014 1.7524112 0.4812564959 4.438518e-01 6.612473e-01 1 26734108 26734218 111 + 0.561 0.307 -1.359
ENSG00000117713 E015 1.0404758 0.1481604011 9.479341e-01   1 26734219 26734273 55 + 0.266 0.302 0.244
ENSG00000117713 E016 0.3503582 0.0309588183 6.424236e-01   1 26752952 26753241 290 + 0.153 0.096 -0.784
ENSG00000117713 E017 160.2993268 0.0023216270 5.536515e-06 1.260021e-04 1 26760856 26761096 241 + 2.268 2.146 -0.407
ENSG00000117713 E018 1.4838368 0.0135336574 5.499515e-02 1.913310e-01 1 26761381 26761383 3 + 0.549 0.240 -1.782
ENSG00000117713 E019 97.3595809 0.0007780159 4.657886e-03 3.277872e-02 1 26761384 26761473 90 + 2.022 1.956 -0.222
ENSG00000117713 E020 131.5099961 0.0032493835 2.220217e-01 4.559315e-01 1 26762152 26762319 168 + 2.116 2.108 -0.025
ENSG00000117713 E021 221.5884784 0.0030463064 5.640767e-04 6.256802e-03 1 26762973 26763285 313 + 2.384 2.304 -0.266
ENSG00000117713 E022 0.1723744 0.0338882459 8.745401e-01   1 26764265 26764794 530 + 0.000 0.096 11.146
ENSG00000117713 E023 0.1723744 0.0338882459 8.745401e-01   1 26764795 26765095 301 + 0.000 0.096 11.146
ENSG00000117713 E024 0.6544085 0.0188478665 1.035799e-01   1 26765386 26765878 493 + 0.356 0.096 -2.368
ENSG00000117713 E025 109.5571629 0.0003606972 7.725023e-05 1.205224e-03 1 26766221 26766269 49 + 2.088 1.993 -0.320
ENSG00000117713 E026 161.4887789 0.0031066678 1.231100e-03 1.165835e-02 1 26766270 26766366 97 + 2.247 2.160 -0.291
ENSG00000117713 E027 1.6975297 0.0136897056 3.309812e-01 5.698555e-01 1 26766367 26766456 90 + 0.494 0.349 -0.780
ENSG00000117713 E028 181.9051697 0.0029401860 6.440525e-02 2.125808e-01 1 26766457 26766566 110 + 2.264 2.233 -0.105
ENSG00000117713 E029 243.3021022 0.0026080705 5.139194e-03 3.534778e-02 1 26767790 26767999 210 + 2.407 2.352 -0.183
ENSG00000117713 E030 12.6983542 0.1156500277 2.664041e-01 5.059104e-01 1 26769174 26771118 1945 + 1.197 1.070 -0.453
ENSG00000117713 E031 214.8274578 0.0002336670 3.988758e-02 1.544245e-01 1 26771119 26771326 208 + 2.327 2.317 -0.034
ENSG00000117713 E032 2.9251147 0.0919517332 7.570996e-02 2.362127e-01 1 26771327 26772499 1173 + 0.754 0.436 -1.436
ENSG00000117713 E033 174.6843446 0.0021655406 2.144599e-02 1.008061e-01 1 26772500 26772632 133 + 2.255 2.215 -0.133
ENSG00000117713 E034 46.8719195 0.0115300694 2.282517e-01 4.631859e-01 1 26772812 26772814 3 + 1.695 1.646 -0.167
ENSG00000117713 E035 182.9365152 0.0010106333 1.431325e-02 7.556928e-02 1 26772815 26772962 148 + 2.271 2.236 -0.114
ENSG00000117713 E036 54.5377807 0.0019490857 7.535391e-01 8.688597e-01 1 26772963 26772963 1 + 1.714 1.737 0.078
ENSG00000117713 E037 53.1950872 0.0023853072 9.202472e-01 9.623396e-01 1 26772964 26772966 3 + 1.696 1.729 0.114
ENSG00000117713 E038 67.7725443 0.0006866248 8.327860e-01 9.153712e-01 1 26772967 26772987 21 + 1.789 1.839 0.170
ENSG00000117713 E039 150.0518558 0.0003543693 3.480694e-03 2.622225e-02 1 26773346 26773496 151 + 2.194 2.147 -0.157
ENSG00000117713 E040 1.0183708 0.0154967547 4.453169e-01   1 26773497 26773579 83 + 0.356 0.240 -0.782
ENSG00000117713 E041 151.5796149 0.0002896099 3.993282e-03 2.911770e-02 1 26773580 26773717 138 + 2.198 2.154 -0.147
ENSG00000117713 E042 117.7554539 0.0050813434 1.970812e-01 4.259270e-01 1 26773802 26773898 97 + 2.073 2.053 -0.068
ENSG00000117713 E043 1.1322382 0.4843782948 8.553293e-01   1 26774116 26774203 88 + 0.357 0.298 -0.375
ENSG00000117713 E044 315.0591392 0.0001795174 6.820091e-01 8.239605e-01 1 26774329 26774869 541 + 2.452 2.503 0.168
ENSG00000117713 E045 93.0428304 0.0010007953 9.147195e-02 2.664135e-01 1 26774870 26774979 110 + 1.885 1.996 0.371
ENSG00000117713 E046 199.2802838 0.0003568178 1.821863e-02 8.975232e-02 1 26774980 26775220 241 + 2.216 2.322 0.355
ENSG00000117713 E047 213.4249563 0.0052508580 4.194930e-01 6.432582e-01 1 26775577 26775707 131 + 2.265 2.338 0.244
ENSG00000117713 E048 5.3059830 0.0348744294 8.793351e-01 9.409543e-01 1 26775817 26775956 140 + 0.783 0.791 0.032
ENSG00000117713 E049 19.9549247 0.1117407537 8.510538e-01 9.256491e-01 1 26778099 26779022 924 + 1.266 1.324 0.202
ENSG00000117713 E050 2389.7205016 0.0022727180 1.689660e-10 1.144233e-08 1 26779023 26782104 3082 + 3.266 3.408 0.473