ENSG00000117632

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374291 ENSG00000117632 HEK293_OSMI2_6hA HEK293_TMG_6hB STMN1 protein_coding protein_coding 421.0804 308.349 441.8002 77.20544 20.2927 0.5188158 174.67231 114.80063 217.16283 23.41212 6.567578 0.9195874 0.4133667 0.3843333 0.49233333 0.10800000 0.16040591 0.02455846 FALSE TRUE
ENST00000455785 ENSG00000117632 HEK293_OSMI2_6hA HEK293_TMG_6hB STMN1 protein_coding protein_coding 421.0804 308.349 441.8002 77.20544 20.2927 0.5188158 169.52522 122.43940 168.49137 30.61274 8.503955 0.4605747 0.4008250 0.3974667 0.38120000 -0.01626667 0.77374856 0.02455846 FALSE TRUE
MSTRG.587.5 ENSG00000117632 HEK293_OSMI2_6hA HEK293_TMG_6hB STMN1 protein_coding   421.0804 308.349 441.8002 77.20544 20.2927 0.5188158 67.65464 67.27649 40.09299 23.74627 5.147734 -0.7466072 0.1639000 0.2036333 0.09006667 -0.11356667 0.02455846 0.02455846 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117632 E001 6.1678436 1.027346e-01 1.220679e-01 3.191184e-01 1 25884181 25885439 1259 - 0.697 0.963 1.042
ENSG00000117632 E002 2.2989731 7.035710e-02 3.778129e-01 6.104057e-01 1 25885440 25885869 430 - 0.448 0.609 0.761
ENSG00000117632 E003 0.0000000       1 25892514 25892607 94 -      
ENSG00000117632 E004 1.7729123 1.397103e-02 2.670266e-01 5.066290e-01 1 25900116 25900117 2 - 0.343 0.534 1.009
ENSG00000117632 E005 467.6159868 4.848332e-03 7.977587e-01 8.950877e-01 1 25900118 25900567 450 - 2.668 2.669 0.004
ENSG00000117632 E006 199.4365766 9.667628e-04 7.530536e-03 4.716946e-02 1 25900568 25900571 4 - 2.259 2.334 0.251
ENSG00000117632 E007 385.5314315 2.897719e-04 9.301996e-03 5.509339e-02 1 25900572 25900594 23 - 2.559 2.607 0.161
ENSG00000117632 E008 1733.1747182 8.318642e-04 6.022200e-07 1.825287e-05 1 25900595 25900740 146 - 3.197 3.277 0.266
ENSG00000117632 E009 5292.3111181 5.059871e-05 1.164964e-04 1.697012e-03 1 25900741 25901087 347 - 3.713 3.730 0.055
ENSG00000117632 E010 11.5444005 9.876932e-03 9.067950e-01 9.554774e-01 1 25901407 25901490 84 - 1.105 1.083 -0.078
ENSG00000117632 E011 3151.9272175 1.267910e-04 1.833945e-01 4.083092e-01 1 25901491 25901611 121 - 3.503 3.490 -0.044
ENSG00000117632 E012 2345.4138774 5.208104e-05 8.980998e-02 2.634526e-01 1 25901612 25901682 71 - 3.375 3.359 -0.052
ENSG00000117632 E013 253.9437292 6.427500e-02 3.233373e-05 5.754571e-04 1 25901683 25903640 1958 - 2.587 2.028 -1.867
ENSG00000117632 E014 2952.0829858 6.314401e-05 7.250397e-02 2.297872e-01 1 25903641 25903813 173 - 3.475 3.461 -0.049
ENSG00000117632 E015 1435.3909274 1.083035e-04 8.046088e-02 2.457883e-01 1 25904664 25904738 75 - 3.165 3.145 -0.067
ENSG00000117632 E016 5.7038257 7.215965e-02 6.706119e-02 2.185395e-01 1 25904918 25905048 131 - 0.958 0.614 -1.374
ENSG00000117632 E017 5.3598147 5.633483e-03 2.218806e-04 2.914637e-03 1 25905049 25905128 80 - 0.974 0.436 -2.282
ENSG00000117632 E018 17.9682808 6.021921e-03 1.160285e-03 1.112798e-02 1 25905144 25905405 262 - 1.393 1.094 -1.055
ENSG00000117632 E019 6.9005403 4.706797e-02 2.045986e-01 4.353859e-01 1 25905406 25905489 84 - 0.985 0.769 -0.828
ENSG00000117632 E020 7.1726960 1.572636e-01 7.804863e-01 8.850462e-01 1 25905852 25905935 84 - 0.888 0.926 0.146
ENSG00000117632 E021 8.3209394 7.313119e-02 2.938460e-01 5.344924e-01 1 25905936 25906361 426 - 0.886 1.034 0.550
ENSG00000117632 E022 0.0000000       1 25906362 25906388 27 -      
ENSG00000117632 E023 706.7119993 6.215422e-04 7.454553e-02 2.338945e-01 1 25906389 25906466 78 - 2.864 2.832 -0.107
ENSG00000117632 E024 0.9545147 2.561318e-01 2.386234e-01   1 25906788 25906991 204 - 0.402 0.127 -2.160