ENSG00000117625

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367005 ENSG00000117625 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR3 protein_coding protein_coding 11.27263 9.235707 13.22351 1.476671 0.06864765 0.5173399 0.80888218 0.4628497 1.326012 0.3868621 0.8414843 1.4984790 0.07100833 0.04760000 0.10040000 0.05280000 0.8991730567 0.0001113433 FALSE TRUE
ENST00000419091 ENSG00000117625 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR3 protein_coding protein_coding 11.27263 9.235707 13.22351 1.476671 0.06864765 0.5173399 1.31166907 1.2815128 2.176325 0.3457231 0.6156065 0.7594462 0.11067917 0.13483333 0.16453333 0.02970000 0.9515603693 0.0001113433 FALSE TRUE
ENST00000452621 ENSG00000117625 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR3 protein_coding protein_coding 11.27263 9.235707 13.22351 1.476671 0.06864765 0.5173399 4.46505988 2.9306957 5.704633 0.5975515 0.2486780 0.9585034 0.39128333 0.31286667 0.43136667 0.11850000 0.2893195614 0.0001113433 FALSE TRUE
ENST00000472734 ENSG00000117625 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR3 protein_coding processed_transcript 11.27263 9.235707 13.22351 1.476671 0.06864765 0.5173399 2.25756845 2.6961144 0.643208 0.7271720 0.1672496 -2.0506085 0.20743750 0.28046667 0.04870000 -0.23176667 0.0001113433 0.0001113433 FALSE FALSE
ENST00000485186 ENSG00000117625 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR3 protein_coding nonsense_mediated_decay 11.27263 9.235707 13.22351 1.476671 0.06864765 0.5173399 0.09125713 0.4650287 0.000000 0.4650287 0.0000000 -5.5699429 0.01421667 0.07103333 0.00000000 -0.07103333 0.8718711269 0.0001113433   FALSE
MSTRG.2994.10 ENSG00000117625 HEK293_OSMI2_6hA HEK293_TMG_6hB RCOR3 protein_coding   11.27263 9.235707 13.22351 1.476671 0.06864765 0.5173399 0.73212778 0.5362303 1.186901 0.1539063 0.2049329 1.1317230 0.06098750 0.05556667 0.08986667 0.03430000 0.6112794521 0.0001113433 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117625 E001 1.0679030 1.3407500924 5.504884e-01   1 211257970 211258376 407 + 0.425 0.000 -11.984
ENSG00000117625 E002 0.3559677 0.4517612267 5.024701e-01   1 211258377 211258407 31 + 0.183 0.000 -12.659
ENSG00000117625 E003 0.6600180 0.0195297846 1.022333e-01   1 211258408 211258490 83 + 0.306 0.000 -14.946
ENSG00000117625 E004 0.5963342 0.0220070066 5.794846e-01   1 211258491 211258525 35 + 0.247 0.148 -0.909
ENSG00000117625 E005 0.3040503 0.0274424043 3.720190e-01   1 211259236 211259278 43 + 0.179 0.000 -13.899
ENSG00000117625 E006 1.0666018 0.0225817856 5.811383e-01   1 211259279 211259365 87 + 0.357 0.258 -0.650
ENSG00000117625 E007 4.7719319 0.0060306961 1.083358e-01 2.962770e-01 1 211259366 211259387 22 + 0.660 0.876 0.870
ENSG00000117625 E008 5.0947632 0.0057120030 1.972760e-01 4.262069e-01 1 211259388 211259395 8 + 0.706 0.876 0.677
ENSG00000117625 E009 30.8651522 0.0221846381 7.459101e-02 2.339681e-01 1 211259396 211259552 157 + 1.428 1.583 0.531
ENSG00000117625 E010 24.3310859 0.0100423022 2.097056e-01 4.415234e-01 1 211259553 211259578 26 + 1.355 1.452 0.335
ENSG00000117625 E011 26.4277076 0.0066646359 2.386923e-01 4.751099e-01 1 211259579 211259605 27 + 1.397 1.482 0.294
ENSG00000117625 E012 46.8464031 0.0008162354 1.954436e-03 1.676135e-02 1 211259606 211259726 121 + 1.602 1.761 0.538
ENSG00000117625 E013 4.1427217 0.0057697071 4.390570e-01 6.580136e-01 1 211259727 211259729 3 + 0.660 0.770 0.454
ENSG00000117625 E014 1.5268343 0.0561623246 9.460030e-01 9.753692e-01 1 211259947 211259974 28 + 0.403 0.418 0.078
ENSG00000117625 E015 4.3226811 0.0067424480 8.841204e-01 9.434502e-01 1 211259975 211260107 133 + 0.727 0.706 -0.086
ENSG00000117625 E016 45.9177789 0.0007665374 2.575252e-02 1.145311e-01 1 211260108 211260164 57 + 1.613 1.729 0.393
ENSG00000117625 E017 14.2587812 0.0024398156 2.053346e-17 4.278593e-15 1 211260929 211261202 274 + 0.684 1.499 2.997
ENSG00000117625 E018 0.6426420 0.0193874923 6.456206e-01   1 211267775 211267870 96 + 0.179 0.259 0.675
ENSG00000117625 E019 42.1130799 0.0016109351 7.603795e-02 2.368574e-01 1 211271232 211271309 78 + 1.660 1.557 -0.348
ENSG00000117625 E020 2.3003445 0.0357074689 5.787190e-01 7.562893e-01 1 211271310 211271527 218 + 0.483 0.583 0.468
ENSG00000117625 E021 6.1645398 0.0049646057 1.907381e-01 4.178120e-01 1 211271528 211271874 347 + 0.911 0.739 -0.671
ENSG00000117625 E022 41.2178611 0.0057831115 4.574920e-01 6.714256e-01 1 211274210 211274262 53 + 1.637 1.589 -0.165
ENSG00000117625 E023 73.9054590 0.0005510829 9.405378e-01 9.725421e-01 1 211276257 211276418 162 + 1.869 1.867 -0.008
ENSG00000117625 E024 56.9624324 0.0007954235 3.652962e-01 6.001848e-01 1 211278117 211278181 65 + 1.768 1.726 -0.144
ENSG00000117625 E025 61.2425706 0.0025449466 1.904662e-01 4.175666e-01 1 211278182 211278241 60 + 1.805 1.739 -0.224
ENSG00000117625 E026 65.9908740 0.0025569760 9.017387e-03 5.390973e-02 1 211279238 211279316 79 + 1.859 1.729 -0.440
ENSG00000117625 E027 83.6076720 0.0013788801 7.195403e-02 2.287216e-01 1 211289178 211289331 154 + 1.945 1.871 -0.248
ENSG00000117625 E028 61.6977939 0.0008340813 9.499771e-02 2.729607e-01 1 211289332 211289396 65 + 1.818 1.742 -0.259
ENSG00000117625 E029 1.6420596 0.0170891480 2.180134e-01 4.510519e-01 1 211291524 211291599 76 + 0.484 0.259 -1.327
ENSG00000117625 E030 57.7712935 0.0007186727 9.497985e-01 9.769811e-01 1 211295676 211295753 78 + 1.761 1.764 0.011
ENSG00000117625 E031 5.5753712 0.2617140436 6.999749e-01 8.356191e-01 1 211301461 211304010 2550 + 0.795 0.826 0.123
ENSG00000117625 E032 0.5173834 0.0396231532 1.926605e-01   1 211304011 211304082 72 + 0.247 0.000 -14.347
ENSG00000117625 E033 52.0435733 0.0008766841 6.287300e-01 7.896752e-01 1 211304083 211304140 58 + 1.705 1.729 0.081
ENSG00000117625 E034 2.7187625 0.0094346595 2.026366e-01 4.328652e-01 1 211312237 211312354 118 + 0.635 0.420 -1.023
ENSG00000117625 E035 13.2621979 0.0904598159 9.412942e-01 9.728713e-01 1 211312355 211312487 133 + 1.154 1.132 -0.079
ENSG00000117625 E036 72.1498164 0.0005472353 2.363961e-01 4.724139e-01 1 211312720 211312835 116 + 1.874 1.824 -0.167
ENSG00000117625 E037 79.4154920 0.0007175599 7.752846e-01 8.818997e-01 1 211312836 211312961 126 + 1.899 1.888 -0.038
ENSG00000117625 E038 29.1627900 0.0013527586 1.995527e-02 9.572801e-02 1 211312962 211313298 337 + 1.406 1.557 0.518
ENSG00000117625 E039 300.6648956 0.0011886352 5.856552e-01 7.606993e-01 1 211313424 211316385 2962 + 2.475 2.463 -0.040