ENSG00000117593

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000648458 ENSG00000117593 HEK293_OSMI2_6hA HEK293_TMG_6hB DARS2 protein_coding protein_coding 41.91922 29.82077 52.05366 8.992718 2.472942 0.8034757 3.683427 1.162429 5.703114 0.4783028 0.4873718 2.2847769 0.07595000 0.03816667 0.10926667 0.07110000 0.00455802 0.00455802 FALSE  
ENST00000648807 ENSG00000117593 HEK293_OSMI2_6hA HEK293_TMG_6hB DARS2 protein_coding protein_coding 41.91922 29.82077 52.05366 8.992718 2.472942 0.8034757 4.683091 3.446641 4.876899 0.8351078 1.0635775 0.4995483 0.10965833 0.12470000 0.09236667 -0.03233333 0.74225477 0.00455802 FALSE  
ENST00000649106 ENSG00000117593 HEK293_OSMI2_6hA HEK293_TMG_6hB DARS2 protein_coding protein_coding 41.91922 29.82077 52.05366 8.992718 2.472942 0.8034757 2.357167 3.119853 1.344465 1.0452489 0.6884668 -1.2083721 0.07207917 0.11743333 0.02463333 -0.09280000 0.49718359 0.00455802 FALSE  
ENST00000649689 ENSG00000117593 HEK293_OSMI2_6hA HEK293_TMG_6hB DARS2 protein_coding protein_coding 41.91922 29.82077 52.05366 8.992718 2.472942 0.8034757 29.251656 21.082852 37.043243 7.0845412 0.9354549 0.8128456 0.69524583 0.68146667 0.71456667 0.03310000 0.94730019 0.00455802 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117593 E001 12.5800882 0.3877791309 4.982916e-01 6.996625e-01 1 173824653 173824660 8 + 1.102 1.160 0.208
ENSG00000117593 E002 12.6401878 0.3793966512 4.562670e-01 6.704795e-01 1 173824661 173824662 2 + 1.094 1.174 0.287
ENSG00000117593 E003 24.5423032 0.5854547558 4.764657e-01 6.846080e-01 1 173824663 173824672 10 + 1.364 1.449 0.295
ENSG00000117593 E004 33.4688211 0.6708290012 4.484080e-01 6.645377e-01 1 173824673 173824683 11 + 1.475 1.600 0.427
ENSG00000117593 E005 63.4248145 0.8799903991 4.709070e-01 6.807593e-01 1 173824684 173824707 24 + 1.750 1.867 0.396
ENSG00000117593 E006 65.3918532 0.8917489591 4.839602e-01 6.897535e-01 1 173824708 173824711 4 + 1.767 1.876 0.368
ENSG00000117593 E007 149.1615865 1.4249304118 5.387354e-01 7.281196e-01 1 173824712 173824842 131 + 2.114 2.238 0.417
ENSG00000117593 E008 98.1723280 1.2872336692 5.336665e-01 7.246540e-01 1 173824843 173824846 4 + 1.939 2.052 0.379
ENSG00000117593 E009 204.8702869 0.0738058565 6.592711e-01 8.095362e-01 1 173824847 173824959 113 + 2.299 2.315 0.054
ENSG00000117593 E010 536.7242142 0.0001250704 5.952567e-08 2.331210e-06 1 173824960 173825356 397 + 2.751 2.686 -0.217
ENSG00000117593 E011 329.8192365 0.0021872623 2.340999e-03 1.931944e-02 1 173826687 173826786 100 + 2.542 2.469 -0.243
ENSG00000117593 E012 6.2832164 0.0048889294 1.729820e-01 3.944612e-01 1 173826787 173828332 1546 + 0.920 0.761 -0.620
ENSG00000117593 E013 252.4202601 0.0002818707 1.555486e-03 1.400547e-02 1 173828333 173828399 67 + 2.420 2.366 -0.180
ENSG00000117593 E014 304.8142251 0.0019067919 1.335038e-01 3.372908e-01 1 173830660 173830761 102 + 2.489 2.467 -0.076
ENSG00000117593 E015 0.7615063 0.1528346394 1.000000e+00   1 173830762 173831027 266 + 0.249 0.254 0.039
ENSG00000117593 E016 260.1210911 0.0002798541 2.143629e-01 4.467897e-01 1 173831535 173831630 96 + 2.415 2.407 -0.027
ENSG00000117593 E017 185.2836618 0.0010258702 7.809734e-01 8.852786e-01 1 173833376 173833427 52 + 2.252 2.281 0.099
ENSG00000117593 E018 190.6666858 0.0016329957 5.445264e-01 7.323153e-01 1 173833428 173833499 72 + 2.259 2.301 0.140
ENSG00000117593 E019 151.0700197 0.0009178505 4.866355e-01 6.916624e-01 1 173834473 173834519 47 + 2.158 2.200 0.142
ENSG00000117593 E020 261.2311281 0.0015148115 5.260355e-01 7.192682e-01 1 173836940 173837046 107 + 2.410 2.412 0.006
ENSG00000117593 E021 274.4384240 0.0002834738 5.574399e-01 7.414326e-01 1 173838190 173838259 70 + 2.430 2.437 0.023
ENSG00000117593 E022 397.2899629 0.0004613210 3.421009e-01 5.798237e-01 1 173839367 173839546 180 + 2.592 2.594 0.006
ENSG00000117593 E023 296.7018592 0.0014574564 1.566847e-01 3.717953e-01 1 173840866 173840973 108 + 2.474 2.456 -0.062
ENSG00000117593 E024 234.7477063 0.0035736121 6.215293e-01 7.848591e-01 1 173845229 173845291 63 + 2.365 2.364 -0.001
ENSG00000117593 E025 315.5801096 0.0026195558 7.146189e-01 8.446970e-01 1 173850327 173850479 153 + 2.480 2.512 0.106
ENSG00000117593 E026 5.2274353 0.0230736034 6.187481e-01 7.830046e-01 1 173851836 173852014 179 + 0.757 0.841 0.335
ENSG00000117593 E027 416.8122423 0.0027501300 3.610515e-02 1.444980e-01 1 173853349 173853567 219 + 2.580 2.659 0.262
ENSG00000117593 E028 2.5344340 0.0086659800 4.363257e-01 6.560086e-01 1 173853568 173853794 227 + 0.589 0.475 -0.537
ENSG00000117593 E029 322.9647415 0.0042037816 2.513220e-01 4.894019e-01 1 173853795 173853905 111 + 2.474 2.543 0.232
ENSG00000117593 E030 3.7153495 0.1841259447 8.212704e-02 2.489851e-01 1 173853906 173854646 741 + 0.788 0.342 -2.099
ENSG00000117593 E031 235.9470292 0.0041352632 3.674339e-01 6.019394e-01 1 173856666 173856741 76 + 2.339 2.403 0.215
ENSG00000117593 E032 18.5025717 0.0535111373 4.738452e-01 6.826962e-01 1 173856742 173857517 776 + 1.323 1.208 -0.401
ENSG00000117593 E033 976.1559168 0.0039913226 1.832479e-01 4.081167e-01 1 173857518 173858808 1291 + 2.954 3.020 0.220