ENSG00000117523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338920 ENSG00000117523 HEK293_OSMI2_6hA HEK293_TMG_6hB PRRC2C protein_coding protein_coding 61.01923 76.5981 55.58823 20.73996 1.526828 -0.462458 4.138819 0.2038133 8.8941361 0.2038133 1.0722948 5.3800523 0.07783750 0.00580000 0.15923333 0.1534333333 2.684351e-02 4.689285e-38 FALSE TRUE
ENST00000367742 ENSG00000117523 HEK293_OSMI2_6hA HEK293_TMG_6hB PRRC2C protein_coding protein_coding 61.01923 76.5981 55.58823 20.73996 1.526828 -0.462458 5.326957 5.1820468 10.3407341 3.5207305 2.6959364 0.9953578 0.10094167 0.07490000 0.18690000 0.1120000000 7.750779e-01 4.689285e-38 FALSE TRUE
ENST00000492811 ENSG00000117523 HEK293_OSMI2_6hA HEK293_TMG_6hB PRRC2C protein_coding processed_transcript 61.01923 76.5981 55.58823 20.73996 1.526828 -0.462458 5.090446 3.4337612 6.2171294 0.5557111 0.9909495 0.8545822 0.09463750 0.06033333 0.11150000 0.0511666667 5.228386e-01 4.689285e-38   FALSE
ENST00000495585 ENSG00000117523 HEK293_OSMI2_6hA HEK293_TMG_6hB PRRC2C protein_coding protein_coding 61.01923 76.5981 55.58823 20.73996 1.526828 -0.462458 5.538512 15.8473907 0.7965705 4.9104365 0.2968894 -4.2972110 0.08122917 0.20066667 0.01463333 -0.1860333333 6.512372e-08 4.689285e-38 FALSE TRUE
ENST00000498596 ENSG00000117523 HEK293_OSMI2_6hA HEK293_TMG_6hB PRRC2C protein_coding protein_coding 61.01923 76.5981 55.58823 20.73996 1.526828 -0.462458 15.311729 20.5348031 0.8743387 7.2221278 0.8743387 -4.5380307 0.20679167 0.24866667 0.01553333 -0.2331333333 5.576717e-02 4.689285e-38 FALSE FALSE
ENST00000644916 ENSG00000117523 HEK293_OSMI2_6hA HEK293_TMG_6hB PRRC2C protein_coding protein_coding 61.01923 76.5981 55.58823 20.73996 1.526828 -0.462458 4.221826 9.4281767 1.7075176 2.4117681 0.1725114 -2.4581833 0.06164583 0.12486667 0.03060000 -0.0942666667 1.022877e-13 4.689285e-38 FALSE TRUE
MSTRG.2588.10 ENSG00000117523 HEK293_OSMI2_6hA HEK293_TMG_6hB PRRC2C protein_coding   61.01923 76.5981 55.58823 20.73996 1.526828 -0.462458 3.806416 0.0000000 8.5542539 0.0000000 0.7810580 9.7421838 0.07465417 0.00000000 0.15383333 0.1538333333 4.689285e-38 4.689285e-38 FALSE TRUE
MSTRG.2588.3 ENSG00000117523 HEK293_OSMI2_6hA HEK293_TMG_6hB PRRC2C protein_coding   61.01923 76.5981 55.58823 20.73996 1.526828 -0.462458 7.157834 9.4319045 7.4611726 1.8896634 1.1027449 -0.3377432 0.12532083 0.13300000 0.13333333 0.0003333333 1.000000e+00 4.689285e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117523 E001 0.1308682 0.0326491905 5.195849e-01   1 171485300 171485500 201 + 0.000 0.118 9.475
ENSG00000117523 E002 0.3088520 0.0254565747 9.664273e-01   1 171485501 171485507 7 + 0.125 0.118 -0.084
ENSG00000117523 E003 0.5823548 0.0211389778 9.105344e-01   1 171485508 171485515 8 + 0.221 0.211 -0.084
ENSG00000117523 E004 0.5941213 0.0207137250 2.713129e-01   1 171485516 171485516 1 + 0.300 0.118 -1.666
ENSG00000117523 E005 0.9692299 0.0172671820 9.061300e-01   1 171485517 171485519 3 + 0.300 0.288 -0.078
ENSG00000117523 E006 1.1472137 0.0148754473 6.162515e-01   1 171485520 171485521 2 + 0.367 0.288 -0.495
ENSG00000117523 E007 2.6120973 0.0084762494 6.267809e-03 4.103766e-02 1 171485522 171485525 4 + 0.725 0.288 -2.196
ENSG00000117523 E008 3.2497500 0.0070286782 1.404503e-02 7.451791e-02 1 171485526 171485529 4 + 0.776 0.410 -1.665
ENSG00000117523 E009 9.4676355 0.0308913857 6.685474e-02 2.179976e-01 1 171485530 171485550 21 + 1.112 0.886 -0.836
ENSG00000117523 E010 11.3300974 0.0059881542 6.298800e-02 2.094303e-01 1 171485551 171485555 5 + 1.164 0.991 -0.627
ENSG00000117523 E011 115.3494008 0.0004086901 4.064519e-27 2.585201e-24 1 171485556 171485595 40 + 2.215 1.862 -1.182
ENSG00000117523 E012 211.4021634 0.0002630303 3.330036e-58 1.713687e-54 1 171485596 171485735 140 + 2.491 2.093 -1.330
ENSG00000117523 E013 0.8703143 0.4711561274 6.661135e-01   1 171509560 171512031 2472 + 0.222 0.297 0.558
ENSG00000117523 E014 292.4365337 0.0009911255 3.565757e-50 1.187348e-46 1 171512032 171512200 169 + 2.625 2.250 -1.252
ENSG00000117523 E015 0.5117739 0.0250817469 5.232710e-01   1 171512201 171512994 794 + 0.221 0.119 -1.081
ENSG00000117523 E016 75.5735753 0.0252739115 1.697645e-04 2.332329e-03 1 171512995 171513000 6 + 2.026 1.702 -1.093
ENSG00000117523 E017 223.8892386 0.0011339879 7.711507e-35 8.969803e-32 1 171513001 171513172 172 + 2.500 2.159 -1.140
ENSG00000117523 E018 161.0020568 0.0026885937 1.501675e-13 1.802253e-11 1 171514536 171514630 95 + 2.331 2.068 -0.877
ENSG00000117523 E019 86.9891682 0.0007046413 1.293895e-09 7.408400e-08 1 171514631 171514645 15 + 2.050 1.831 -0.736
ENSG00000117523 E020 202.5425973 0.0074434807 1.163490e-10 8.141215e-09 1 171515734 171515859 126 + 2.444 2.136 -1.029
ENSG00000117523 E021 295.4217311 0.0013560785 5.234904e-34 5.887465e-31 1 171517591 171517814 224 + 2.612 2.292 -1.064
ENSG00000117523 E022 184.6605526 0.0005378223 2.918919e-30 2.371768e-27 1 171522177 171522259 83 + 2.405 2.101 -1.016
ENSG00000117523 E023 0.1426347 0.0334222476 4.654042e-01   1 171522515 171522556 42 + 0.124 0.000 -12.628
ENSG00000117523 E024 223.2473224 0.0073619791 1.994949e-10 1.326500e-08 1 171523221 171523348 128 + 2.483 2.186 -0.988
ENSG00000117523 E025 111.3971408 0.0039200844 3.836385e-11 2.960047e-09 1 171523349 171523354 6 + 2.180 1.898 -0.946
ENSG00000117523 E026 1.0666018 0.0207779284 2.036224e-01   1 171523355 171523434 80 + 0.425 0.211 -1.407
ENSG00000117523 E027 195.6103397 0.0070630719 8.565568e-10 5.073703e-08 1 171523435 171523522 88 + 2.422 2.135 -0.960
ENSG00000117523 E028 261.1909374 0.0061053242 2.099494e-09 1.151623e-07 1 171524821 171524965 145 + 2.536 2.276 -0.868
ENSG00000117523 E029 184.0043708 0.0003309973 5.254646e-23 2.165922e-20 1 171527791 171527844 54 + 2.383 2.135 -0.830
ENSG00000117523 E030 595.2208809 0.0055769289 7.072391e-07 2.103055e-05 1 171532343 171532961 619 + 2.864 2.676 -0.625
ENSG00000117523 E031 232.6376494 0.0003754630 6.940075e-12 6.147143e-10 1 171535428 171535597 170 + 2.443 2.296 -0.492
ENSG00000117523 E032 91.8176080 0.0004946057 1.846202e-07 6.424747e-06 1 171536029 171536034 6 + 2.055 1.880 -0.587
ENSG00000117523 E033 296.3623729 0.0002070368 2.445285e-18 5.857061e-16 1 171536035 171536278 244 + 2.555 2.390 -0.549
ENSG00000117523 E034 346.1372999 0.0001526605 2.232738e-28 1.579876e-25 1 171537263 171537473 211 + 2.633 2.437 -0.655
ENSG00000117523 E035 2139.2830321 0.0005322918 5.144221e-25 2.615590e-22 1 171539971 171541829 1859 + 3.388 3.272 -0.387
ENSG00000117523 E036 674.1092859 0.0001006944 3.180576e-11 2.496002e-09 1 171541830 171542229 400 + 2.869 2.796 -0.241
ENSG00000117523 E037 408.3920247 0.0003518302 4.292098e-02 1.623342e-01 1 171545479 171545687 209 + 2.625 2.606 -0.062
ENSG00000117523 E038 375.8229321 0.0009619881 1.109750e-02 6.278476e-02 1 171550086 171550240 155 + 2.597 2.556 -0.137
ENSG00000117523 E039 869.1003765 0.0009003493 8.022588e-01 8.976496e-01 1 171557240 171557954 715 + 2.935 2.945 0.035
ENSG00000117523 E040 390.9910208 0.0001687276 3.168729e-01 5.568675e-01 1 171557955 171558143 189 + 2.595 2.597 0.006
ENSG00000117523 E041 183.1574444 0.0002364232 8.211449e-02 2.489632e-01 1 171561018 171561020 3 + 2.280 2.255 -0.084
ENSG00000117523 E042 346.0388414 0.0002184809 1.489253e-01 3.607580e-01 1 171561021 171561103 83 + 2.546 2.538 -0.029
ENSG00000117523 E043 463.4986755 0.0001897538 2.449942e-01 4.822782e-01 1 171566233 171566421 189 + 2.648 2.688 0.134
ENSG00000117523 E044 488.8527434 0.0003669022 4.831099e-04 5.521818e-03 1 171566592 171566843 252 + 2.646 2.729 0.277
ENSG00000117523 E045 305.1484150 0.0001632965 7.573143e-02 2.362449e-01 1 171568247 171568339 93 + 2.457 2.515 0.193
ENSG00000117523 E046 319.6525686 0.0021516102 1.242229e-01 3.224046e-01 1 171571320 171571421 102 + 2.474 2.535 0.202
ENSG00000117523 E047 501.4108672 0.0004559931 5.255114e-03 3.596370e-02 1 171574927 171575128 202 + 2.665 2.736 0.236
ENSG00000117523 E048 501.3006991 0.0001363955 4.924507e-08 1.968215e-06 1 171577434 171577637 204 + 2.642 2.753 0.369
ENSG00000117523 E049 384.2282670 0.0002185447 1.583068e-15 2.585014e-13 1 171579354 171579466 113 + 2.489 2.664 0.582
ENSG00000117523 E050 406.3391304 0.0001483225 1.050363e-29 8.145010e-27 1 171579828 171579964 137 + 2.478 2.710 0.770
ENSG00000117523 E051 619.1055861 0.0001357949 2.334076e-37 3.387861e-34 1 171583956 171584187 232 + 2.672 2.887 0.716
ENSG00000117523 E052 397.8840477 0.0001564200 2.104403e-28 1.495297e-25 1 171584419 171584526 108 + 2.472 2.701 0.762
ENSG00000117523 E053 57.0354314 0.0013841680 3.049155e-05 5.475486e-04 1 171584527 171584541 15 + 1.631 1.862 0.780
ENSG00000117523 E054 342.4508322 0.0007411160 4.956593e-13 5.392335e-11 1 171587003 171587072 70 + 2.431 2.621 0.636
ENSG00000117523 E055 484.3809707 0.0031049636 1.691648e-08 7.544138e-07 1 171587073 171587221 149 + 2.570 2.773 0.677
ENSG00000117523 E056 208.0443677 0.0034688464 1.504108e-09 8.494581e-08 1 171587648 171587661 14 + 2.170 2.424 0.849
ENSG00000117523 E057 429.7625884 0.0011403682 4.842479e-14 6.399722e-12 1 171587662 171587751 90 + 2.519 2.719 0.667
ENSG00000117523 E058 587.2871473 0.0008026023 8.408746e-15 1.250437e-12 1 171588379 171588505 127 + 2.670 2.847 0.591
ENSG00000117523 E059 61.9152960 0.0078546000 1.180852e-02 6.567013e-02 1 171589369 171589605 237 + 1.708 1.870 0.547
ENSG00000117523 E060 181.2996250 0.0003409144 5.395270e-15 8.232173e-13 1 171591152 171591200 49 + 2.123 2.362 0.799
ENSG00000117523 E061 116.1066994 0.0022766428 1.004991e-08 4.721808e-07 1 171591201 171591204 4 + 1.919 2.170 0.840
ENSG00000117523 E062 21.0724716 0.1209761879 9.358912e-01 9.701504e-01 1 171591205 171591313 109 + 1.339 1.346 0.023
ENSG00000117523 E063 3341.8085728 0.0017033084 2.053166e-33 2.206802e-30 1 171591587 171593511 1925 + 3.382 3.623 0.801