ENSG00000117450

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319248 ENSG00000117450 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDX1 protein_coding protein_coding 1005.777 917.1408 885.5784 124.5376 48.16367 -0.05052262 939.86382 890.53739 728.7860 127.46056 39.916640 -0.2891774 0.91381250 0.9695 0.8229333 -0.1465667 0.0004471809 0.0004471809 FALSE TRUE
MSTRG.1079.7 ENSG00000117450 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDX1 protein_coding   1005.777 917.1408 885.5784 124.5376 48.16367 -0.05052262 52.09301 11.57542 148.3545 11.02902 7.696823 3.6787633 0.07153333 0.0140 0.1676000 0.1536000 0.1699332397 0.0004471809 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117450 E001 1.196902 0.016643447 0.962880797   1 45510914 45511035 122 - 0.332 0.320 -0.077
ENSG00000117450 E002 8.735661 0.118471546 0.999961874 1.00000000 1 45511036 45511050 15 - 1.013 0.960 -0.196
ENSG00000117450 E003 6170.515537 2.310687126 0.541854914 0.73040301 1 45511051 45511414 364 - 3.651 3.855 0.679
ENSG00000117450 E004 2.986518 0.066700482 0.631321563 0.79123981 1 45513473 45513509 37 - 0.650 0.565 -0.375
ENSG00000117450 E005 6541.181230 0.032284290 0.151283261 0.36421005 1 45514507 45514637 131 - 3.750 3.845 0.315
ENSG00000117450 E006 3804.671535 0.001193818 0.046201129 0.17053587 1 45514873 45514895 23 - 3.548 3.588 0.133
ENSG00000117450 E007 6810.011341 0.002752663 0.405927322 0.63300762 1 45514896 45514995 100 - 3.827 3.824 -0.009
ENSG00000117450 E008 8349.214157 0.007892572 0.244560182 0.48171709 1 45515654 45515807 154 - 3.929 3.904 -0.083
ENSG00000117450 E009 5546.704487 0.009961391 0.045914012 0.16983896 1 45518938 45518989 52 - 3.778 3.705 -0.241
ENSG00000117450 E010 5792.982262 0.008844093 0.114546428 0.30673361 1 45518990 45519054 65 - 3.784 3.735 -0.164
ENSG00000117450 E011 101.851215 0.010002312 0.015251686 0.07901566 1 45521609 45521828 220 - 1.908 2.060 0.511
ENSG00000117450 E012 3983.701442 0.008163191 0.076513188 0.23778386 1 45521829 45521857 29 - 3.627 3.568 -0.195
ENSG00000117450 E013 2579.152920 0.005593226 0.001350246 0.01253678 1 45521858 45521976 119 - 3.461 3.359 -0.339
ENSG00000117450 E014 23.411904 0.010709014 0.033398036 0.13717783 1 45522778 45523047 270 - 1.252 1.441 0.658
ENSG00000117450 E015 0.000000       1 45542677 45542732 56 -