ENSG00000117385

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000236040 ENSG00000117385 HEK293_OSMI2_6hA HEK293_TMG_6hB P3H1 protein_coding protein_coding 63.7522 77.95218 45.19361 1.99697 0.8667802 -0.7863366 3.420110 3.315109 2.766216 0.8223880 0.08665382 -0.2602816 0.0566500 0.04286667 0.06126667 0.01840000 6.717918e-01 1.009346e-24 FALSE TRUE
ENST00000296388 ENSG00000117385 HEK293_OSMI2_6hA HEK293_TMG_6hB P3H1 protein_coding protein_coding 63.7522 77.95218 45.19361 1.99697 0.8667802 -0.7863366 36.338487 46.037354 22.258842 5.4318442 0.69787683 -1.0480917 0.5632250 0.58853333 0.49246667 -0.09606667 6.646343e-01 1.009346e-24 FALSE TRUE
ENST00000397054 ENSG00000117385 HEK293_OSMI2_6hA HEK293_TMG_6hB P3H1 protein_coding protein_coding 63.7522 77.95218 45.19361 1.99697 0.8667802 -0.7863366 2.889136 3.514664 4.644849 0.3000959 0.59488661 0.4012487 0.0508000 0.04510000 0.10310000 0.05800000 1.678162e-02 1.009346e-24 FALSE TRUE
ENST00000460031 ENSG00000117385 HEK293_OSMI2_6hA HEK293_TMG_6hB P3H1 protein_coding retained_intron 63.7522 77.95218 45.19361 1.99697 0.8667802 -0.7863366 6.309400 6.979661 6.225996 1.0987095 0.17425444 -0.1646024 0.1067292 0.09030000 0.13780000 0.04750000 3.918775e-01 1.009346e-24 FALSE TRUE
ENST00000462474 ENSG00000117385 HEK293_OSMI2_6hA HEK293_TMG_6hB P3H1 protein_coding processed_transcript 63.7522 77.95218 45.19361 1.99697 0.8667802 -0.7863366 4.795179 5.589810 0.000000 0.5642818 0.00000000 -9.1292341 0.0587250 0.07143333 0.00000000 -0.07143333 1.009346e-24 1.009346e-24   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117385 E001 0.2027342 0.0343081950 1.000000e+00   1 42746335 42746373 39 - 0.000 0.089 8.155
ENSG00000117385 E002 2.0356735 0.0110093962 4.396856e-02 1.649967e-01 1 42746374 42746374 1 - 0.164 0.544 2.443
ENSG00000117385 E003 42.5510844 0.0008687135 7.122486e-02 2.272118e-01 1 42746375 42746417 43 - 1.538 1.644 0.359
ENSG00000117385 E004 221.9801659 0.0003107361 8.878159e-05 1.352818e-03 1 42746418 42746507 90 - 2.249 2.353 0.347
ENSG00000117385 E005 219.3579463 0.0004888334 1.011682e-02 5.863314e-02 1 42746508 42746530 23 - 2.269 2.338 0.233
ENSG00000117385 E006 718.4047944 0.0004071202 1.497562e-08 6.758448e-07 1 42746531 42746852 322 - 2.765 2.858 0.310
ENSG00000117385 E007 49.3822575 0.0468868574 3.901055e-01 6.205753e-01 1 42746853 42747252 400 - 1.724 1.650 -0.251
ENSG00000117385 E008 52.2980337 0.0011639437 4.138676e-01 6.388939e-01 1 42747253 42747271 19 - 1.728 1.684 -0.147
ENSG00000117385 E009 513.9876811 0.0005545992 8.370252e-04 8.584222e-03 1 42747272 42747412 141 - 2.638 2.703 0.216
ENSG00000117385 E010 26.8588481 0.0515018246 9.362086e-01 9.703285e-01 1 42747413 42747576 164 - 1.408 1.425 0.060
ENSG00000117385 E011 350.6705568 0.0002604335 1.985014e-02 9.536345e-02 1 42747723 42747757 35 - 2.485 2.533 0.162
ENSG00000117385 E012 376.5914964 0.0002270205 1.085871e-01 2.967301e-01 1 42747758 42747798 41 - 2.528 2.559 0.105
ENSG00000117385 E013 492.2992917 0.0003017531 8.368255e-02 2.521650e-01 1 42748200 42748317 118 - 2.643 2.674 0.103
ENSG00000117385 E014 33.2801255 0.0329098838 2.574368e-01 4.961793e-01 1 42748318 42748743 426 - 1.577 1.471 -0.364
ENSG00000117385 E015 16.2288343 0.1204329431 2.049209e-01 4.358098e-01 1 42749901 42750185 285 - 1.316 1.144 -0.608
ENSG00000117385 E016 526.7547194 0.0006746602 2.801311e-01 5.202671e-01 1 42750186 42750336 151 - 2.679 2.700 0.070
ENSG00000117385 E017 2.1470408 0.0628191103 7.151363e-01 8.450503e-01 1 42751641 42751724 84 - 0.521 0.448 -0.361
ENSG00000117385 E018 2.1422392 0.0098990173 3.373080e-01 5.756877e-01 1 42751725 42751740 16 - 0.575 0.413 -0.799
ENSG00000117385 E019 2.8210382 0.0140204567 3.599255e-02 1.442000e-01 1 42751741 42751834 94 - 0.749 0.413 -1.538
ENSG00000117385 E020 433.5779032 0.0008638572 7.778524e-01 8.834044e-01 1 42752274 42752369 96 - 2.614 2.607 -0.024
ENSG00000117385 E021 525.1242780 0.0001600284 2.325576e-01 4.681274e-01 1 42752537 42752664 128 - 2.679 2.698 0.063
ENSG00000117385 E022 506.4708704 0.0001805344 5.033809e-02 1.804851e-01 1 42754869 42754979 111 - 2.653 2.686 0.110
ENSG00000117385 E023 290.6635880 0.0002194726 4.235492e-01 6.462744e-01 1 42754980 42754990 11 - 2.423 2.440 0.057
ENSG00000117385 E024 78.6489634 0.0252957903 7.141711e-02 2.276279e-01 1 42754991 42755164 174 - 1.964 1.819 -0.487
ENSG00000117385 E025 324.4491667 0.0022919225 4.959148e-01 6.981492e-01 1 42755165 42755217 53 - 2.469 2.488 0.066
ENSG00000117385 E026 409.3540682 0.0015553507 2.311656e-01 4.664911e-01 1 42755548 42755637 90 - 2.604 2.572 -0.108
ENSG00000117385 E027 3.3712951 0.2000336658 4.011719e-01 6.292670e-01 1 42756401 42756455 55 - 0.710 0.571 -0.600
ENSG00000117385 E028 510.3476986 0.0004341184 9.901541e-05 1.482159e-03 1 42757783 42757922 140 - 2.726 2.653 -0.244
ENSG00000117385 E029 0.8619444 0.0193874923 7.495844e-01   1 42757923 42757945 23 - 0.283 0.225 -0.436
ENSG00000117385 E030 478.5991794 0.0002080876 1.009832e-04 1.507629e-03 1 42758852 42758983 132 - 2.696 2.627 -0.232
ENSG00000117385 E031 327.5873648 0.0002032485 7.366443e-06 1.609100e-04 1 42759201 42759256 56 - 2.550 2.456 -0.314
ENSG00000117385 E032 394.5900678 0.0002774622 5.042814e-06 1.159748e-04 1 42759257 42759390 134 - 2.628 2.538 -0.299
ENSG00000117385 E033 7.7340593 0.0041186393 9.416028e-02 2.714760e-01 1 42759391 42759393 3 - 1.046 0.852 -0.726
ENSG00000117385 E034 13.4762451 0.2335077827 1.279659e-02 6.960557e-02 1 42759986 42762322 2337 - 1.400 0.906 -1.771
ENSG00000117385 E035 213.1281497 0.0002138286 8.612379e-07 2.495445e-05 1 42762323 42762346 24 - 2.383 2.257 -0.420
ENSG00000117385 E036 313.6049287 0.0002928325 1.809941e-05 3.508786e-04 1 42762347 42762475 129 - 2.530 2.436 -0.313
ENSG00000117385 E037 425.5063864 0.0009661939 1.140234e-01 3.058301e-01 1 42766507 42767084 578 - 2.578 2.613 0.119