ENSG00000117298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264205 ENSG00000117298 HEK293_OSMI2_6hA HEK293_TMG_6hB ECE1 protein_coding protein_coding 24.9314 28.98231 22.96916 1.930777 1.240597 -0.335344 0.7303555 0.01743621 2.279652 0.01743621 1.3431723 6.3829033 0.02990833 0.0005333333 0.09636667 0.09583333 3.230484e-01 2.780437e-12 FALSE TRUE
ENST00000374893 ENSG00000117298 HEK293_OSMI2_6hA HEK293_TMG_6hB ECE1 protein_coding protein_coding 24.9314 28.98231 22.96916 1.930777 1.240597 -0.335344 3.7116545 4.80347871 0.000000 1.28191235 0.0000000 -8.9109361 0.14220417 0.1638666667 0.00000000 -0.16386667 2.780437e-12 2.780437e-12 FALSE TRUE
ENST00000415912 ENSG00000117298 HEK293_OSMI2_6hA HEK293_TMG_6hB ECE1 protein_coding protein_coding 24.9314 28.98231 22.96916 1.930777 1.240597 -0.335344 17.7811424 23.27362036 15.532427 1.68300457 0.6905714 -0.5831036 0.71471250 0.8045666667 0.68006667 -0.12450000 4.446580e-01 2.780437e-12 FALSE TRUE
ENST00000528294 ENSG00000117298 HEK293_OSMI2_6hA HEK293_TMG_6hB ECE1 protein_coding processed_transcript 24.9314 28.98231 22.96916 1.930777 1.240597 -0.335344 0.2718887 0.00000000 1.649218 0.00000000 1.6492181 7.3743597 0.01096667 0.0000000000 0.06576667 0.06576667 8.717428e-01 2.780437e-12 FALSE FALSE
MSTRG.485.5 ENSG00000117298 HEK293_OSMI2_6hA HEK293_TMG_6hB ECE1 protein_coding   24.9314 28.98231 22.96916 1.930777 1.240597 -0.335344 1.2087093 0.31529316 1.829430 0.19638166 0.3954575 2.4994462 0.05009167 0.0106333333 0.07970000 0.06906667 1.626128e-01 2.780437e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117298 E001 0.1308682 0.031254805 1.000000e+00   1 21217247 21217249 3 - 0.000 0.100 7.963
ENSG00000117298 E002 19.5785158 0.131445030 4.553142e-02 0.1688750665 1 21217250 21217280 31 - 0.967 1.432 1.655
ENSG00000117298 E003 454.8468274 1.354980308 2.857971e-01 0.5264136311 1 21217281 21217978 698 - 2.295 2.777 1.608
ENSG00000117298 E004 502.0354186 1.416041224 3.216740e-01 0.5611987013 1 21217979 21218583 605 - 2.368 2.813 1.485
ENSG00000117298 E005 732.9116377 1.638650594 4.744381e-01 0.6831557737 1 21218584 21219813 1230 - 2.647 2.947 0.997
ENSG00000117298 E006 146.2431351 1.074992460 4.360973e-01 0.6558864971 1 21219814 21219893 80 - 1.977 2.240 0.880
ENSG00000117298 E007 131.1526172 1.063293896 4.828900e-01 0.6890377909 1 21219894 21219936 43 - 1.964 2.181 0.728
ENSG00000117298 E008 107.1364477 0.988885696 4.840432e-01 0.6898196259 1 21219937 21219958 22 - 1.884 2.091 0.695
ENSG00000117298 E009 200.4940923 1.177937275 4.249881e-01 0.6472466637 1 21219959 21220131 173 - 2.093 2.383 0.969
ENSG00000117298 E010 143.9770065 0.002599645 8.790773e-03 0.0529067729 1 21221747 21221842 96 - 2.017 2.224 0.693
ENSG00000117298 E011 2.3640123 0.009306469 1.221529e-01 0.3192670793 1 21221843 21222081 239 - 0.625 0.449 -0.831
ENSG00000117298 E012 269.9672204 0.009136448 3.803627e-01 0.6124949934 1 21225250 21225440 191 - 2.377 2.448 0.235
ENSG00000117298 E013 180.2666148 0.023320362 8.064777e-02 0.2461386107 1 21227159 21227226 68 - 2.258 2.240 -0.060
ENSG00000117298 E014 211.3546936 0.015534545 6.289454e-02 0.2092244997 1 21227931 21228041 111 - 2.318 2.314 -0.013
ENSG00000117298 E015 3.5296765 0.062983469 6.815976e-01 0.8236507972 1 21233105 21233557 453 - 0.627 0.643 0.069
ENSG00000117298 E016 108.8572804 0.030373908 2.378305e-01 0.4740559551 1 21233558 21233569 12 - 2.028 2.030 0.007
ENSG00000117298 E017 161.3981631 0.014706734 5.613867e-02 0.1939386865 1 21233570 21233661 92 - 2.205 2.195 -0.034
ENSG00000117298 E018 171.5303470 0.008127284 2.690641e-02 0.1180229068 1 21235850 21235927 78 - 2.225 2.226 0.002
ENSG00000117298 E019 217.0946060 0.014232098 3.432996e-02 0.1397541997 1 21236746 21236844 99 - 2.336 2.321 -0.050
ENSG00000117298 E020 124.3088444 0.008756282 4.839832e-03 0.0337458874 1 21238134 21238148 15 - 2.112 2.071 -0.138
ENSG00000117298 E021 204.4766727 0.014413008 9.226289e-03 0.0548247364 1 21238149 21238244 96 - 2.330 2.283 -0.158
ENSG00000117298 E022 0.8619444 0.070982549 7.568445e-01   1 21238245 21238350 106 - 0.257 0.250 -0.057
ENSG00000117298 E023 236.6614119 0.010935104 1.801495e-03 0.0157115528 1 21244989 21245103 115 - 2.398 2.344 -0.180
ENSG00000117298 E024 228.1943497 0.018405768 3.112366e-03 0.0240907631 1 21247221 21247363 143 - 2.400 2.314 -0.287
ENSG00000117298 E025 219.8322599 0.005860417 1.490952e-03 0.0135530404 1 21255947 21256138 192 - 2.349 2.325 -0.078
ENSG00000117298 E026 0.0000000       1 21256688 21256717 30 -      
ENSG00000117298 E027 142.7943208 0.007877165 1.442827e-02 0.0759923955 1 21257525 21257590 66 - 2.157 2.145 -0.039
ENSG00000117298 E028 168.7064052 0.007691647 2.520439e-02 0.1128290988 1 21258693 21258839 147 - 2.220 2.220 0.000
ENSG00000117298 E029 107.9486230 0.002810847 1.157141e-02 0.0647115478 1 21260271 21260312 42 - 2.026 2.025 -0.004
ENSG00000117298 E030 152.8347701 0.002604792 6.440253e-04 0.0069529757 1 21260313 21260392 80 - 2.189 2.169 -0.068
ENSG00000117298 E031 136.6044203 0.003872707 2.598788e-05 0.0004766541 1 21272699 21272745 47 - 2.168 2.100 -0.228
ENSG00000117298 E032 157.8567828 0.015263637 8.105622e-03 0.0498089838 1 21272746 21272831 86 - 2.226 2.165 -0.203
ENSG00000117298 E033 81.7011017 0.022294132 4.667090e-02 0.1717462677 1 21272832 21272834 3 - 1.936 1.887 -0.166
ENSG00000117298 E034 132.0443199 0.020383346 1.977282e-02 0.0951106146 1 21272835 21272911 77 - 2.151 2.087 -0.215
ENSG00000117298 E035 137.6965874 0.021574965 5.958771e-02 0.2018261843 1 21279191 21279332 142 - 2.154 2.116 -0.129
ENSG00000117298 E036 0.2922838 0.026848688 6.112421e-01   1 21279333 21279549 217 - 0.147 0.100 -0.641
ENSG00000117298 E037 0.3150090 0.026695105 6.155530e-01   1 21279831 21280069 239 - 0.147 0.100 -0.636
ENSG00000117298 E038 100.6591201 0.019416654 3.884342e-01 0.6192021193 1 21290070 21290156 87 - 1.968 2.014 0.152
ENSG00000117298 E039 0.4812263 0.020979934 1.000000e+00   1 21290157 21290257 101 - 0.147 0.181 0.359
ENSG00000117298 E040 3.9321292 0.519552573 3.606143e-01 0.5961244697 1 21290364 21290464 101 - 0.494 0.766 1.188
ENSG00000117298 E041 0.0000000       1 21294154 21294424 271 -      
ENSG00000117298 E042 0.0000000       1 21298817 21298999 183 -      
ENSG00000117298 E043 0.7664957 0.017267182 2.316200e-01   1 21344937 21345375 439 - 0.344 0.181 -1.223
ENSG00000117298 E044 72.6822079 0.025739453 8.440279e-01 0.9215988299 1 21345376 21345572 197 - 1.795 1.892 0.328