ENSG00000117266

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360066 ENSG00000117266 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK18 protein_coding protein_coding 6.388176 10.46225 2.304691 1.516777 0.2635541 -2.17768 0.5717484 0.9817965 0.0000000 0.29930297 0.00000000 -6.631972 0.0824000 0.09980000 0.00000000 -0.099800000 0.009849931 0.009849931 FALSE  
ENST00000429964 ENSG00000117266 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK18 protein_coding protein_coding 6.388176 10.46225 2.304691 1.516777 0.2635541 -2.17768 0.5505365 0.4207570 0.0708325 0.42075705 0.07083250 -2.413867 0.0841750 0.03460000 0.03886667 0.004266667 0.943960755 0.009849931 FALSE  
ENST00000484080 ENSG00000117266 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK18 protein_coding retained_intron 6.388176 10.46225 2.304691 1.516777 0.2635541 -2.17768 3.5310546 6.0025412 1.2300937 1.25338258 0.16545919 -2.277526 0.5285917 0.56073333 0.53253333 -0.028200000 0.956973210 0.009849931 FALSE  
ENST00000504162 ENSG00000117266 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK18 protein_coding retained_intron 6.388176 10.46225 2.304691 1.516777 0.2635541 -2.17768 0.3271940 0.5809542 0.1571880 0.18716328 0.09276173 -1.821575 0.0515875 0.05203333 0.06670000 0.014666667 1.000000000 0.009849931 FALSE  
ENST00000506784 ENSG00000117266 HEK293_OSMI2_6hA HEK293_TMG_6hB CDK18 protein_coding protein_coding 6.388176 10.46225 2.304691 1.516777 0.2635541 -2.17768 0.3455297 0.8211912 0.2227405 0.08769886 0.05234496 -1.836458 0.0563375 0.08533333 0.09383333 0.008500000 0.936306860 0.009849931 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000117266 E001 0.5474829 0.104619351 1.000000000   1 205504596 205504596 1 + 0.000 0.140 8.563
ENSG00000117266 E002 0.5474829 0.104619351 1.000000000   1 205504597 205504597 1 + 0.000 0.140 10.607
ENSG00000117266 E003 0.5474829 0.104619351 1.000000000   1 205504598 205504598 1 + 0.000 0.140 10.607
ENSG00000117266 E004 2.7631655 0.013224031 0.361508485 0.59691875 1 205504599 205504658 60 + 0.262 0.461 1.187
ENSG00000117266 E005 2.9658997 0.028914226 0.323341594 0.56268386 1 205504659 205504668 10 + 0.262 0.481 1.288
ENSG00000117266 E006 3.7336128 0.007398292 0.169872574 0.39030655 1 205504669 205504687 19 + 0.262 0.561 1.670
ENSG00000117266 E007 3.5612384 0.007815749 0.193396378 0.42136859 1 205504688 205504693 6 + 0.262 0.546 1.599
ENSG00000117266 E008 3.8054789 0.022635952 0.174584406 0.39660292 1 205504694 205504704 11 + 0.262 0.563 1.679
ENSG00000117266 E009 5.8580280 0.005475429 0.031376965 0.13143369 1 205504705 205504748 44 + 0.262 0.722 2.364
ENSG00000117266 E010 5.4221996 0.005618047 0.041000199 0.15731048 1 205504749 205504796 48 + 0.262 0.700 2.275
ENSG00000117266 E011 1.0821019 0.170151260 0.412868956   1 205504797 205504801 5 + 0.000 0.271 11.590
ENSG00000117266 E012 2.5825362 0.102496230 0.096117559 0.27492711 1 205504802 205504878 77 + 0.000 0.466 12.613
ENSG00000117266 E013 0.5171231 0.891731092 1.000000000   1 205516817 205517034 218 + 0.000 0.143 10.152
ENSG00000117266 E014 0.8812730 0.258957409 0.690244828   1 205522429 205523008 580 + 0.263 0.181 -0.684
ENSG00000117266 E015 0.8812730 0.258957409 0.690244828   1 205523009 205523146 138 + 0.263 0.181 -0.684
ENSG00000117266 E016 8.3569994 0.062932534 0.152799156 0.36635857 1 205523147 205523216 70 + 0.544 0.839 1.243
ENSG00000117266 E017 6.9376721 0.062836734 0.106361204 0.29292410 1 205523217 205523297 81 + 0.426 0.782 1.602
ENSG00000117266 E018 2.0643157 0.010864776 0.525906730 0.71918970 1 205523298 205523482 185 + 0.262 0.399 0.859
ENSG00000117266 E019 5.8313723 0.005111706 0.027899371 0.12099883 1 205523483 205523507 25 + 0.262 0.731 2.403
ENSG00000117266 E020 6.4378573 0.005131049 0.016569631 0.08386447 1 205523508 205523545 38 + 0.262 0.770 2.558
ENSG00000117266 E021 4.4635237 0.006348587 0.080659665 0.24614757 1 205523546 205523553 8 + 0.262 0.642 2.026
ENSG00000117266 E022 5.1722347 0.005426522 0.047576474 0.17397139 1 205523554 205523559 6 + 0.262 0.689 2.227
ENSG00000117266 E023 7.5998925 0.003803405 0.006458212 0.04197133 1 205523560 205523625 66 + 0.262 0.830 2.797
ENSG00000117266 E024 2.5151821 0.081973931 0.950372731 0.97719478 1 205523626 205523715 90 + 0.425 0.438 0.068
ENSG00000117266 E025 11.3047222 0.003849877 0.378188564 0.61067584 1 205524232 205524357 126 + 0.833 0.955 0.464
ENSG00000117266 E026 9.7437473 0.003106379 0.278917879 0.51897874 1 205525139 205525195 57 + 1.006 0.854 -0.571
ENSG00000117266 E027 17.3785161 0.002304747 0.113420356 0.30486040 1 205526065 205526179 115 + 1.245 1.072 -0.621
ENSG00000117266 E028 17.5815400 0.003511082 0.436034109 0.65581986 1 205526367 205526461 95 + 1.179 1.086 -0.335
ENSG00000117266 E029 0.0000000       1 205526733 205526774 42 +      
ENSG00000117266 E030 15.1615778 0.002158368 0.857771062 0.92921459 1 205526775 205526837 63 + 1.071 1.043 -0.104
ENSG00000117266 E031 1.3623117 0.013696863 1.000000000   1 205526838 205527263 426 + 0.262 0.274 0.083
ENSG00000117266 E032 0.7204775 0.070392998 0.530713303   1 205527410 205527793 384 + 0.262 0.140 -1.120
ENSG00000117266 E033 11.7394918 0.002741347 0.348695453 0.58613956 1 205527794 205527827 34 + 0.833 0.962 0.490
ENSG00000117266 E034 14.7724172 0.002267856 0.498381864 0.69970820 1 205527828 205527917 90 + 0.968 1.048 0.293
ENSG00000117266 E035 7.7667929 0.033914708 0.930145209 0.96706749 1 205528048 205528054 7 + 0.777 0.785 0.031
ENSG00000117266 E036 12.5993384 0.002891282 0.430225041 0.65127246 1 205528055 205528130 76 + 0.883 0.985 0.384
ENSG00000117266 E037 9.4316321 0.005405170 0.709451728 0.84144200 1 205528131 205528168 38 + 0.833 0.882 0.191
ENSG00000117266 E038 1.7199422 0.204223617 0.294156581 0.53473654 1 205528663 205528998 336 + 0.542 0.299 -1.320
ENSG00000117266 E039 12.2767328 0.011991410 0.588084240 0.76239727 1 205528999 205529096 98 + 1.040 0.964 -0.280
ENSG00000117266 E040 2.1710536 0.010185892 0.409582951 0.63574725 1 205529097 205529193 97 + 0.543 0.376 -0.853
ENSG00000117266 E041 2.2014135 0.010145837 0.409582316 0.63574725 1 205529194 205529200 7 + 0.543 0.376 -0.853
ENSG00000117266 E042 3.4807127 0.008385990 0.522491580 0.71669687 1 205529201 205529218 18 + 0.635 0.512 -0.558
ENSG00000117266 E043 15.6007577 0.034009793 0.883712681 0.94322417 1 205529219 205529323 105 + 1.040 1.068 0.104
ENSG00000117266 E044 34.3732514 0.020090562 0.753133273 0.86862182 1 205529324 205529429 106 + 1.412 1.380 -0.112
ENSG00000117266 E045 5.0648996 0.005359055 0.534007388 0.72491511 1 205529430 205529520 91 + 0.543 0.654 0.497
ENSG00000117266 E046 24.3040194 0.001515310 0.496582263 0.69859316 1 205529521 205529563 43 + 1.303 1.232 -0.250
ENSG00000117266 E047 8.6442234 0.090574237 0.103251691 0.28764435 1 205529564 205530185 622 + 1.077 0.774 -1.146
ENSG00000117266 E048 2.6338040 0.245666510 0.199444802 0.42903142 1 205530186 205530258 73 + 0.721 0.375 -1.638
ENSG00000117266 E049 27.8083125 0.001451129 0.251289389 0.48936241 1 205530259 205530312 54 + 1.385 1.277 -0.374
ENSG00000117266 E050 23.4185445 0.002735726 0.856131208 0.92835434 1 205530313 205530349 37 + 1.246 1.222 -0.085
ENSG00000117266 E051 1.9038954 0.051677250 0.312789402 0.55313890 1 205530350 205530627 278 + 0.542 0.328 -1.136
ENSG00000117266 E052 35.8572302 0.001346785 0.774430327 0.88139374 1 205530628 205530705 78 + 1.427 1.397 -0.104
ENSG00000117266 E053 216.7845782 0.007455198 0.228251215 0.46318593 1 205531344 205532793 1450 + 2.214 2.158 -0.186