ENSG00000116991

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308942 ENSG00000116991 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L2 protein_coding protein_coding 4.770986 5.341715 4.806599 0.7894188 0.2427136 -0.1519866 0.3271523 0.7971905 0.1041253 0.11421281 0.05578049 -2.8222900 0.06591667 0.14953333 0.02200000 -0.12753333 0.02361713 0.02361713 FALSE TRUE
ENST00000366630 ENSG00000116991 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L2 protein_coding protein_coding 4.770986 5.341715 4.806599 0.7894188 0.2427136 -0.1519866 0.6394123 0.8041927 0.7217672 0.46323641 0.29578890 -0.1539855 0.13561667 0.12986667 0.14486667 0.01500000 0.95620714 0.02361713 FALSE TRUE
ENST00000494056 ENSG00000116991 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L2 protein_coding retained_intron 4.770986 5.341715 4.806599 0.7894188 0.2427136 -0.1519866 0.2538097 0.3090324 0.2578403 0.07889975 0.17547106 -0.2523299 0.05112500 0.06533333 0.05316667 -0.01216667 0.91636476 0.02361713   FALSE
ENST00000675685 ENSG00000116991 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L2 protein_coding protein_coding 4.770986 5.341715 4.806599 0.7894188 0.2427136 -0.1519866 2.8753777 3.0319624 2.8441853 0.44806902 0.41464508 -0.0919233 0.60577917 0.56826667 0.60180000 0.03353333 0.96387314 0.02361713 FALSE TRUE
MSTRG.3267.12 ENSG00000116991 HEK293_OSMI2_6hA HEK293_TMG_6hB SIPA1L2 protein_coding   4.770986 5.341715 4.806599 0.7894188 0.2427136 -0.1519866 0.1340135 0.0000000 0.2581635 0.00000000 0.25816348 4.7450409 0.02745417 0.00000000 0.05126667 0.05126667 0.85654325 0.02361713 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116991 E001 0.2027342 0.257914510 1.000000e+00   1 232397965 232397965 1 - 0.000 0.093 9.826
ENSG00000116991 E002 2.4187473 0.017013676 7.813781e-01 0.8854780814 1 232397966 232397989 24 - 0.507 0.525 0.084
ENSG00000116991 E003 2.4187473 0.017013676 7.813781e-01 0.8854780814 1 232397990 232397992 3 - 0.507 0.525 0.084
ENSG00000116991 E004 86.8566518 0.005271863 4.491305e-05 0.0007593099 1 232397993 232398709 717 - 1.802 1.972 0.573
ENSG00000116991 E005 15.9137138 0.002538143 3.595557e-01 0.5954540204 1 232398710 232398711 2 - 1.181 1.218 0.129
ENSG00000116991 E006 27.7671005 0.012531171 8.701056e-02 0.2582743802 1 232398712 232398777 66 - 1.362 1.466 0.360
ENSG00000116991 E007 39.0512597 0.016136422 1.174291e-01 0.3115379183 1 232398778 232398870 93 - 1.527 1.604 0.261
ENSG00000116991 E008 52.4184275 0.007263674 1.004570e-01 0.2826173661 1 232398871 232398961 91 - 1.672 1.725 0.181
ENSG00000116991 E009 65.4326137 0.011335440 7.886040e-02 0.2425527870 1 232398962 232399141 180 - 1.763 1.822 0.199
ENSG00000116991 E010 42.8782122 0.009347019 5.223358e-01 0.7165677273 1 232399142 232399273 132 - 1.637 1.624 -0.044
ENSG00000116991 E011 29.2041252 0.005751076 1.238997e-01 0.3219014093 1 232402392 232402473 82 - 1.564 1.408 -0.537
ENSG00000116991 E012 2.8941192 0.086314879 7.600134e-01 0.8725469267 1 232402474 232402766 293 - 0.563 0.582 0.089
ENSG00000116991 E013 30.8612050 0.097372434 1.644830e-01 0.3833522623 1 232403448 232403532 85 - 1.589 1.416 -0.594
ENSG00000116991 E014 23.8290024 0.192802227 4.289260e-01 0.6502718303 1 232403533 232403571 39 - 1.430 1.341 -0.308
ENSG00000116991 E015 1.8572801 0.167183837 7.652268e-01 0.8757850943 1 232404125 232404178 54 - 0.502 0.392 -0.574
ENSG00000116991 E016 30.3577816 0.101973811 6.505793e-01 0.8039126721 1 232415494 232415625 132 - 1.487 1.469 -0.062
ENSG00000116991 E017 0.0000000       1 232415626 232415870 245 -      
ENSG00000116991 E018 0.0000000       1 232419875 232419920 46 -      
ENSG00000116991 E019 38.9853201 0.001645941 4.917702e-03 0.0341821722 1 232425589 232425808 220 - 1.499 1.626 0.433
ENSG00000116991 E020 35.1321620 0.002974164 5.928400e-03 0.0393919225 1 232428411 232428564 154 - 1.440 1.577 0.469
ENSG00000116991 E021 44.7929729 0.000957537 6.895004e-02 0.2226738018 1 232432247 232432471 225 - 1.607 1.659 0.178
ENSG00000116991 E022 0.6783511 0.026865642 1.604660e-01   1 232433414 232433566 153 - 0.000 0.288 11.809
ENSG00000116991 E023 50.3780101 0.022031570 2.300225e-01 0.4651853379 1 232439108 232439496 389 - 1.665 1.706 0.139
ENSG00000116991 E024 28.4588262 0.099601828 1.056902e-01 0.2918503877 1 232441291 232441394 104 - 1.564 1.375 -0.650
ENSG00000116991 E025 26.7423167 0.181708271 1.295254e-01 0.3310717514 1 232441768 232441868 101 - 1.541 1.345 -0.675
ENSG00000116991 E026 26.2074281 0.137897088 2.386422e-01 0.4750614547 1 232443602 232443685 84 - 1.493 1.367 -0.437
ENSG00000116991 E027 39.1700618 0.004803101 6.371436e-01 0.7951149765 1 232445529 232445786 258 - 1.604 1.589 -0.054
ENSG00000116991 E028 46.8070916 0.003306139 4.367011e-01 0.6562330423 1 232460887 232461161 275 - 1.663 1.663 0.000
ENSG00000116991 E029 1.2389762 0.054203123 1.566284e-01   1 232462193 232462417 225 - 0.508 0.230 -1.666
ENSG00000116991 E030 83.5728877 0.140491148 7.416934e-01 0.8614949785 1 232464840 232465416 577 - 1.966 1.870 -0.322
ENSG00000116991 E031 42.5660287 0.036924745 5.882431e-01 0.7625100397 1 232471371 232471528 158 - 1.709 1.569 -0.474
ENSG00000116991 E032 36.5015338 0.002340986 1.607117e-01 0.3778456314 1 232479627 232479730 104 - 1.642 1.508 -0.459
ENSG00000116991 E033 40.7096075 0.001491911 4.844789e-01 0.6901888749 1 232483792 232483966 175 - 1.660 1.572 -0.298
ENSG00000116991 E034 0.0000000       1 232490686 232490873 188 -      
ENSG00000116991 E035 36.1464655 0.074477939 2.082896e-01 0.4397687456 1 232490874 232491062 189 - 1.621 1.508 -0.385
ENSG00000116991 E036 25.8848416 0.153096376 2.833256e-01 0.5237656271 1 232493527 232493660 134 - 1.474 1.371 -0.353
ENSG00000116991 E037 126.9460404 0.057781750 7.081983e-01 0.8406370174 1 232513857 232515608 1752 - 2.187 2.022 -0.553
ENSG00000116991 E038 3.2989381 0.123983231 2.094606e-01 0.4412319138 1 232533490 232533583 94 - 0.770 0.520 -1.078
ENSG00000116991 E039 0.3641499 0.052412015 7.136453e-01   1 232561469 232561558 90 - 0.160 0.092 -0.914
ENSG00000116991 E040 4.2751328 0.015984579 2.876077e-02 0.1236485220 1 232574174 232574222 49 - 0.908 0.554 -1.457
ENSG00000116991 E041 0.0000000       1 232608827 232608911 85 -      
ENSG00000116991 E042 0.6081007 0.020273893 9.964053e-03   1 232608912 232608988 77 - 0.443 0.000 -13.679
ENSG00000116991 E043 4.8913437 0.030074846 4.736383e-01 0.6825318287 1 232629869 232630429 561 - 0.855 0.699 -0.625
ENSG00000116991 E044 0.2852693 0.039720255 9.005221e-02   1 232630430 232630571 142 - 0.275 0.000 -12.676