ENSG00000116984

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366576 ENSG00000116984 HEK293_OSMI2_6hA HEK293_TMG_6hB MTR protein_coding protein_coding 16.17194 15.90134 17.39591 4.091984 0.6467444 0.1295219 2.4506361 4.1138201 0.3210779 1.81087093 0.32107789 -3.6387388 0.18163750 0.22060000 0.01770000 -0.20290000 0.121218195 0.001711805 FALSE TRUE
ENST00000366577 ENSG00000116984 HEK293_OSMI2_6hA HEK293_TMG_6hB MTR protein_coding protein_coding 16.17194 15.90134 17.39591 4.091984 0.6467444 0.1295219 7.6793927 9.0995336 8.3491480 2.57129313 0.31768961 -0.1240213 0.47128750 0.56126667 0.48180000 -0.07946667 0.586306066 0.001711805 FALSE TRUE
ENST00000535889 ENSG00000116984 HEK293_OSMI2_6hA HEK293_TMG_6hB MTR protein_coding protein_coding 16.17194 15.90134 17.39591 4.091984 0.6467444 0.1295219 1.1441987 0.2476081 1.4946779 0.04334138 0.28983613 2.5462049 0.05985833 0.01783333 0.08523333 0.06740000 0.001711805 0.001711805 FALSE TRUE
ENST00000674797 ENSG00000116984 HEK293_OSMI2_6hA HEK293_TMG_6hB MTR protein_coding protein_coding 16.17194 15.90134 17.39591 4.091984 0.6467444 0.1295219 0.9223289 0.3494939 1.5913400 0.23570660 0.06009785 2.1552405 0.05441667 0.02480000 0.09146667 0.06666667 0.429923140 0.001711805 FALSE TRUE
ENST00000679842 ENSG00000116984 HEK293_OSMI2_6hA HEK293_TMG_6hB MTR protein_coding protein_coding 16.17194 15.90134 17.39591 4.091984 0.6467444 0.1295219 0.6475112 0.2402314 1.5180429 0.03148454 0.34285583 2.6103505 0.03549167 0.01766667 0.08860000 0.07093333 0.017404939 0.001711805 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116984 E001 2.2413424 0.0109094772 5.009479e-01 7.014761e-01 1 236795260 236795291 32 + 0.547 0.474 -0.351
ENSG00000116984 E002 6.4151845 0.0615335234 2.770646e-01 5.170827e-01 1 236795292 236795311 20 + 0.943 0.814 -0.496
ENSG00000116984 E003 13.3239592 0.0027871905 2.241879e-02 1.039714e-01 1 236795312 236795325 14 + 1.232 1.075 -0.562
ENSG00000116984 E004 38.3688436 0.0055673312 2.382457e-01 4.746049e-01 1 236795326 236795386 61 + 1.612 1.592 -0.071
ENSG00000116984 E005 35.8470311 0.0010947580 1.824737e-01 4.072327e-01 1 236795387 236795394 8 + 1.582 1.560 -0.076
ENSG00000116984 E006 44.5328859 0.0009854636 2.948781e-01 5.353891e-01 1 236795395 236795438 44 + 1.663 1.664 0.003
ENSG00000116984 E007 68.9347142 0.0033497848 3.227976e-01 5.621426e-01 1 236795439 236795614 176 + 1.845 1.854 0.030
ENSG00000116984 E008 42.3161856 0.0063552943 6.821830e-01 8.240921e-01 1 236795615 236795681 67 + 1.626 1.658 0.109
ENSG00000116984 E009 39.3821184 0.0085879357 1.000850e-02 5.820201e-02 1 236795682 236795703 22 + 1.669 1.541 -0.438
ENSG00000116984 E010 49.0407825 0.0080233569 1.907945e-02 9.275001e-02 1 236795704 236795737 34 + 1.751 1.646 -0.356
ENSG00000116984 E011 28.3667223 0.0019488836 5.169039e-02 1.837206e-01 1 236803428 236803430 3 + 1.508 1.432 -0.260
ENSG00000116984 E012 106.6263769 0.0006852870 5.676188e-02 1.954488e-01 1 236803431 236803642 212 + 2.041 2.030 -0.036
ENSG00000116984 E013 76.5291327 0.0062635562 3.594278e-02 1.440655e-01 1 236806144 236806233 90 + 1.923 1.860 -0.215
ENSG00000116984 E014 73.2224396 0.0006823646 1.902811e-05 3.664562e-04 1 236808704 236808773 70 + 1.930 1.806 -0.419
ENSG00000116984 E015 9.6140978 0.1613570794 3.575907e-01 5.937715e-01 1 236809462 236810502 1041 + 1.099 0.933 -0.609
ENSG00000116984 E016 78.4941993 0.0005046610 1.971048e-04 2.642113e-03 1 236810503 236810595 93 + 1.943 1.849 -0.316
ENSG00000116984 E017 0.7491197 0.0797184647 2.132794e-01   1 236811645 236811701 57 + 0.119 0.364 2.061
ENSG00000116984 E018 75.7950452 0.0006668637 2.078339e-04 2.760223e-03 1 236812738 236812844 107 + 1.929 1.830 -0.332
ENSG00000116984 E019 64.5380297 0.0008188760 9.615693e-03 5.645581e-02 1 236815604 236815663 60 + 1.845 1.783 -0.209
ENSG00000116984 E020 90.1962731 0.0004566724 8.634540e-04 8.799469e-03 1 236816449 236816543 95 + 1.994 1.925 -0.233
ENSG00000116984 E021 73.7918457 0.0005786394 2.520175e-04 3.241809e-03 1 236824119 236824219 101 + 1.922 1.826 -0.324
ENSG00000116984 E022 67.3003642 0.0006657643 6.258187e-04 6.802253e-03 1 236825338 236825399 62 + 1.879 1.786 -0.316
ENSG00000116984 E023 77.7400861 0.0022079025 3.199509e-05 5.705063e-04 1 236826829 236826896 68 + 1.961 1.825 -0.456
ENSG00000116984 E024 91.8648262 0.0026856184 4.972540e-05 8.278938e-04 1 236829189 236829268 80 + 2.027 1.899 -0.430
ENSG00000116984 E025 109.9557902 0.0004304743 7.740280e-08 2.953218e-06 1 236831966 236832078 113 + 2.102 1.972 -0.436
ENSG00000116984 E026 94.2737382 0.0006690805 9.872124e-07 2.808231e-05 1 236835547 236835615 69 + 2.034 1.905 -0.436
ENSG00000116984 E027 91.8645548 0.0005650359 2.302498e-07 7.795397e-06 1 236835616 236835687 72 + 2.029 1.888 -0.473
ENSG00000116984 E028 105.3348606 0.0003953976 3.075126e-09 1.614803e-07 1 236838414 236838518 105 + 2.094 1.942 -0.511
ENSG00000116984 E029 97.6502007 0.0004723996 7.818831e-09 3.763655e-07 1 236838519 236838599 81 + 2.065 1.910 -0.521
ENSG00000116984 E030 118.3344432 0.0003704593 1.518590e-08 6.835185e-07 1 236850344 236850523 180 + 2.134 2.003 -0.440
ENSG00000116984 E031 93.0508522 0.0087693914 4.592040e-02 1.698436e-01 1 236852521 236852637 117 + 1.995 1.947 -0.160
ENSG00000116984 E032 110.2043952 0.0094185184 6.887140e-02 2.225299e-01 1 236852948 236853088 141 + 2.064 2.028 -0.122
ENSG00000116984 E033 106.5607589 0.0005044934 4.104163e-04 4.831090e-03 1 236859833 236859922 90 + 2.064 1.997 -0.223
ENSG00000116984 E034 108.6685948 0.0013772114 8.747364e-04 8.887780e-03 1 236861125 236861277 153 + 2.075 2.005 -0.233
ENSG00000116984 E035 96.1418822 0.0005816594 3.046749e-01 5.452489e-01 1 236862236 236862343 108 + 1.980 1.998 0.060
ENSG00000116984 E036 92.2444337 0.0069903327 4.714175e-01 6.811692e-01 1 236863454 236863554 101 + 1.965 1.972 0.021
ENSG00000116984 E037 66.5020334 0.0016149652 1.327544e-01 3.361327e-01 1 236873773 236873840 68 + 1.836 1.821 -0.049
ENSG00000116984 E038 95.7358978 0.0013147814 4.324020e-01 6.530348e-01 1 236874726 236874846 121 + 1.974 1.999 0.086
ENSG00000116984 E039 103.5883893 0.0004041363 7.260098e-01 8.517317e-01 1 236880755 236880836 82 + 1.999 2.043 0.150
ENSG00000116984 E040 110.1193242 0.0004139413 1.172583e-01 3.112308e-01 1 236885121 236885219 99 + 2.044 2.047 0.011
ENSG00000116984 E041 104.7232644 0.0012237385 2.147469e-03 1.806139e-02 1 236886292 236886367 76 + 2.052 1.993 -0.198
ENSG00000116984 E042 18.6408093 0.1241538724 4.410661e-01 6.595279e-01 1 236886368 236889180 2813 + 1.191 1.376 0.651
ENSG00000116984 E043 138.7842720 0.0003802935 9.620495e-03 5.647946e-02 1 236889181 236889336 156 + 2.159 2.136 -0.075
ENSG00000116984 E044 97.3702818 0.0004589464 5.669851e-01 7.480070e-01 1 236891133 236891222 90 + 1.978 2.014 0.122
ENSG00000116984 E045 93.1926086 0.0004610897 7.223753e-02 2.292794e-01 1 236891223 236891329 107 + 1.911 2.034 0.415
ENSG00000116984 E046 43.6182286 0.1804561486 3.457714e-01 5.833460e-01 1 236891330 236894356 3027 + 1.488 1.769 0.955
ENSG00000116984 E047 144.9857701 0.0003353774 1.575015e-01 3.729573e-01 1 236894357 236894557 201 + 2.113 2.211 0.329
ENSG00000116984 E048 15.0570108 0.1671786091 2.615753e-01 5.006538e-01 1 236894558 236895357 800 + 1.035 1.328 1.044
ENSG00000116984 E049 132.6781914 0.0004360376 8.171041e-01 9.064682e-01 1 236895358 236895550 193 + 2.093 2.157 0.213
ENSG00000116984 E050 120.1063045 0.0005715729 3.408461e-01 5.787865e-01 1 236897006 236897118 113 + 2.068 2.092 0.079
ENSG00000116984 E051 289.0934928 0.0001996516 4.801205e-02 1.750177e-01 1 236897558 236898003 446 + 2.455 2.470 0.051
ENSG00000116984 E052 284.9272702 0.0034680092 6.787809e-01 8.219549e-01 1 236898004 236898522 519 + 2.419 2.494 0.251
ENSG00000116984 E053 331.4283658 0.0001959789 2.322465e-03 1.920195e-02 1 236898523 236899109 587 + 2.458 2.576 0.391
ENSG00000116984 E054 1713.6858540 0.0031029854 1.855414e-17 3.899652e-15 1 236899110 236903778 4669 + 3.091 3.343 0.836
ENSG00000116984 E055 52.9467091 0.0015884392 2.049583e-11 1.673396e-09 1 236903779 236903981 203 + 1.473 1.890 1.418
ENSG00000116984 E056 1.4444869 0.0442489520 6.777732e-01 8.213145e-01 1 236907045 236907206 162 + 0.412 0.365 -0.266
ENSG00000116984 E057 1.6363823 0.2227006231 7.207377e-01 8.486413e-01 1 236913298 236913424 127 + 0.358 0.503 0.770
ENSG00000116984 E058 0.1614157 0.0348791814 4.684688e-01   1 236913425 236913430 6 + 0.119 0.000 -8.343
ENSG00000116984 E059 2.0352115 0.0329894601 7.049043e-01 8.386504e-01 1 236916741 236916920 180 + 0.506 0.473 -0.163
ENSG00000116984 E060 3.5348381 0.1456848581 8.364887e-02 2.521024e-01 1 236920811 236921278 468 + 0.413 0.805 1.763