ENSG00000116962

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264187 ENSG00000116962 HEK293_OSMI2_6hA HEK293_TMG_6hB NID1 protein_coding protein_coding 30.94076 41.89912 25.25165 3.353558 0.9533227 -0.7303154 26.224306 38.352824 21.3977986 3.0775318 0.7018139 -0.8415725 0.8458542 0.91530000 0.84783333 -0.067466667 0.0263900 0.02639 FALSE TRUE
ENST00000366595 ENSG00000116962 HEK293_OSMI2_6hA HEK293_TMG_6hB NID1 protein_coding protein_coding 30.94076 41.89912 25.25165 3.353558 0.9533227 -0.7303154 1.927094 1.419344 0.9386788 0.2698583 0.2015318 -0.5913616 0.0633250 0.03333333 0.03766667 0.004333333 0.9700462 0.02639 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116962 E001 544.8833 1.425937986 0.3819211753 0.613852107 1 235975830 235976361 532 - 2.443 2.809 1.217
ENSG00000116962 E002 257.7003 1.120988640 0.2993953190 0.539800436 1 235976362 235976415 54 - 2.080 2.493 1.380
ENSG00000116962 E003 226.1149 1.089436410 0.3143975815 0.554611978 1 235976416 235976435 20 - 2.043 2.433 1.304
ENSG00000116962 E004 240.6932 1.103162180 0.3059759403 0.546626328 1 235976436 235976454 19 - 2.061 2.461 1.337
ENSG00000116962 E005 1325.3832 1.775949605 0.4787070520 0.686254607 1 235976455 235977587 1133 - 2.885 3.182 0.989
ENSG00000116962 E006 473.2800 1.458139405 0.5015986991 0.701949666 1 235977588 235977988 401 - 2.486 2.721 0.783
ENSG00000116962 E007 249.1202 0.029882042 0.5370689559 0.727070735 1 235978995 235979107 113 - 2.291 2.416 0.418
ENSG00000116962 E008 302.8220 0.004869567 0.3575496574 0.593747242 1 235979822 235979945 124 - 2.419 2.484 0.216
ENSG00000116962 E009 319.3673 0.012160081 0.1828302654 0.407667658 1 235980496 235980653 158 - 2.463 2.494 0.103
ENSG00000116962 E010 332.6513 0.007504572 0.0587353610 0.199936163 1 235981611 235981782 172 - 2.490 2.508 0.058
ENSG00000116962 E011 314.5336 0.008276611 0.0279599785 0.121165853 1 235985379 235985505 127 - 2.478 2.477 -0.005
ENSG00000116962 E012 311.1018 0.006343158 0.0149863854 0.078032590 1 235990886 235991058 173 - 2.474 2.473 -0.003
ENSG00000116962 E013 326.5394 0.016534673 0.5147742262 0.711502621 1 235993645 235993872 228 - 2.449 2.515 0.219
ENSG00000116962 E014 261.4813 0.019728602 0.2226983576 0.456654910 1 236011921 236012037 117 - 2.383 2.405 0.073
ENSG00000116962 E015 140.7386 0.017473023 0.1311746581 0.333668789 1 236012038 236012043 6 - 2.130 2.130 0.001
ENSG00000116962 E016 253.0694 0.020575554 0.2110470460 0.443007583 1 236013411 236013560 150 - 2.373 2.388 0.050
ENSG00000116962 E017 228.2434 0.013572599 0.0570464872 0.196157075 1 236017148 236017273 126 - 2.345 2.335 -0.033
ENSG00000116962 E018 258.3410 0.016562570 0.0856567808 0.255771482 1 236024070 236024213 144 - 2.396 2.390 -0.020
ENSG00000116962 E019 327.4563 0.009086262 0.0230331382 0.106055979 1 236025896 236026141 246 - 2.500 2.492 -0.028
ENSG00000116962 E020 271.7590 0.008638166 0.0100900895 0.058542168 1 236029550 236029750 201 - 2.429 2.405 -0.080
ENSG00000116962 E021 318.8527 0.010493912 0.0010222107 0.010083932 1 236032401 236032652 252 - 2.527 2.458 -0.230
ENSG00000116962 E022 220.5759 0.008931505 0.0006918756 0.007374404 1 236038104 236038253 150 - 2.369 2.298 -0.236
ENSG00000116962 E023 418.5446 0.016498226 0.0343660939 0.139871855 1 236041910 236042292 383 - 2.618 2.591 -0.092
ENSG00000116962 E024 330.5636 0.017538718 0.0074782703 0.046923418 1 236045457 236045683 227 - 2.544 2.472 -0.239
ENSG00000116962 E025 337.9277 0.011213925 0.0051952196 0.035645743 1 236048690 236048989 300 - 2.537 2.492 -0.152
ENSG00000116962 E026 187.8424 0.016290499 0.1610357571 0.378361286 1 236064855 236065185 331 - 2.247 2.259 0.040