ENSG00000116906

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366647 ENSG00000116906 HEK293_OSMI2_6hA HEK293_TMG_6hB GNPAT protein_coding protein_coding 33.54188 15.50423 53.27801 2.135965 3.297806 1.780219 23.7701904 9.0991326 40.372079 2.0372431 2.5126252 2.148330 0.67266250 0.58333333 0.75790000 0.17456667 4.095052e-01 4.469508e-16 FALSE TRUE
ENST00000469332 ENSG00000116906 HEK293_OSMI2_6hA HEK293_TMG_6hB GNPAT protein_coding processed_transcript 33.54188 15.50423 53.27801 2.135965 3.297806 1.780219 1.6890565 0.7543758 2.260546 0.3125295 0.1473292 1.570686 0.06297917 0.05670000 0.04313333 -0.01356667 1.000000e+00 4.469508e-16   FALSE
ENST00000492459 ENSG00000116906 HEK293_OSMI2_6hA HEK293_TMG_6hB GNPAT protein_coding processed_transcript 33.54188 15.50423 53.27801 2.135965 3.297806 1.780219 1.8365989 1.0808582 3.211914 0.4280186 0.7624112 1.562454 0.06024583 0.08213333 0.05890000 -0.02323333 9.857226e-01 4.469508e-16 FALSE FALSE
MSTRG.3265.5 ENSG00000116906 HEK293_OSMI2_6hA HEK293_TMG_6hB GNPAT protein_coding   33.54188 15.50423 53.27801 2.135965 3.297806 1.780219 1.2253407 1.4053483 0.000000 0.4222763 0.0000000 -7.145013 0.05112083 0.08690000 0.00000000 -0.08690000 4.469508e-16 4.469508e-16 FALSE TRUE
MSTRG.3265.6 ENSG00000116906 HEK293_OSMI2_6hA HEK293_TMG_6hB GNPAT protein_coding   33.54188 15.50423 53.27801 2.135965 3.297806 1.780219 0.8759621 2.0344848 0.000000 2.0344848 0.0000000 -7.675594 0.04296667 0.11460000 0.00000000 -0.11460000 8.010379e-01 4.469508e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116906 E001 1.177401 0.0657861345 0.0910759043   1 231241207 231241211 5 + 0.372 0.000 -11.173
ENSG00000116906 E002 2.497437 0.0838433782 0.0102882803 0.059353420 1 231241212 231241215 4 + 0.593 0.000 -12.266
ENSG00000116906 E003 87.516667 0.0004325378 0.0061472842 0.040453780 1 231241216 231241330 115 + 1.925 1.806 -0.401
ENSG00000116906 E004 136.140343 0.0003601000 0.0001493058 0.002090491 1 231241331 231241431 101 + 2.118 1.984 -0.449
ENSG00000116906 E005 97.286467 0.0008974623 0.0085362099 0.051778575 1 231241432 231241456 25 + 1.971 1.860 -0.374
ENSG00000116906 E006 69.268665 0.0024404513 0.0066181595 0.042791384 1 231250961 231250963 3 + 1.832 1.686 -0.493
ENSG00000116906 E007 201.051565 0.0021521678 0.0012472427 0.011773137 1 231250964 231251143 180 + 2.283 2.168 -0.386
ENSG00000116906 E008 5.667892 0.0055065124 0.3058627451 0.546533343 1 231258222 231258309 88 + 0.734 0.876 0.560
ENSG00000116906 E009 213.218511 0.0024774278 0.3693740232 0.603552919 1 231260507 231260653 147 + 2.289 2.258 -0.101
ENSG00000116906 E010 123.080614 0.0034107412 0.8865338016 0.944864909 1 231260654 231260683 30 + 2.043 2.052 0.031
ENSG00000116906 E011 207.703675 0.0008635682 0.3788967417 0.611329334 1 231262723 231262852 130 + 2.276 2.253 -0.077
ENSG00000116906 E012 210.815487 0.0005815209 0.6171858751 0.781895850 1 231265293 231265420 128 + 2.270 2.288 0.062
ENSG00000116906 E013 160.795158 0.0003137521 0.6428730748 0.798731640 1 231265712 231265787 76 + 2.160 2.149 -0.038
ENSG00000116906 E014 197.329868 0.0037557207 0.8330151487 0.915466010 1 231266014 231266133 120 + 2.244 2.241 -0.010
ENSG00000116906 E015 130.738293 0.0012672588 0.2072785003 0.438562702 1 231266134 231266165 32 + 2.076 2.031 -0.153
ENSG00000116906 E016 212.828551 0.0002856242 0.7408844678 0.860986398 1 231266277 231266407 131 + 2.278 2.272 -0.021
ENSG00000116906 E017 297.069925 0.0002580064 0.9449359267 0.974762137 1 231267680 231267903 224 + 2.423 2.424 0.004
ENSG00000116906 E018 9.521833 0.0242578145 0.8422176562 0.920711507 1 231267904 231267911 8 + 0.990 0.959 -0.117
ENSG00000116906 E019 22.630951 0.1530511964 0.6487912942 0.802737124 1 231269863 231270056 194 + 1.287 1.406 0.413
ENSG00000116906 E020 380.996967 0.0008719369 0.7790981870 0.884216097 1 231270758 231271000 243 + 2.528 2.538 0.031
ENSG00000116906 E021 228.493859 0.0002487033 0.6937623274 0.831530973 1 231272312 231272391 80 + 2.306 2.319 0.045
ENSG00000116906 E022 286.781539 0.0011022408 0.2063163222 0.437346442 1 231273922 231274062 141 + 2.397 2.434 0.123
ENSG00000116906 E023 18.521981 0.1440977291 0.8489570376 0.924354888 1 231274896 231275220 325 + 1.219 1.287 0.237
ENSG00000116906 E024 197.826095 0.0030834365 0.0062633980 0.041014461 1 231275221 231275320 100 + 2.214 2.317 0.343
ENSG00000116906 E025 186.747847 0.0028046182 0.0108467007 0.061711255 1 231275405 231275498 94 + 2.193 2.289 0.319
ENSG00000116906 E026 165.548564 0.0003489986 0.0014188438 0.013034775 1 231276135 231276196 62 + 2.140 2.239 0.331
ENSG00000116906 E027 297.759263 0.0011406140 0.0351657629 0.142023719 1 231277499 231277973 475 + 2.405 2.464 0.196