ENSG00000116885

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000235532 ENSG00000116885 HEK293_OSMI2_6hA HEK293_TMG_6hB OSCP1 protein_coding protein_coding 10.26164 8.915207 7.692452 0.6216807 0.5438573 -0.2125679 4.9025108 3.6468876 4.7179783 0.3593583 0.25656907 0.3706071 0.4922667 0.40820000 0.61466667 0.20646667 0.002597646 0.002597646 FALSE TRUE
ENST00000354267 ENSG00000116885 HEK293_OSMI2_6hA HEK293_TMG_6hB OSCP1 protein_coding protein_coding 10.26164 8.915207 7.692452 0.6216807 0.5438573 -0.2125679 3.2124843 3.2264672 1.5422707 0.3303972 0.26167930 -1.0600397 0.2988542 0.36236667 0.19873333 -0.16363333 0.102020367 0.002597646 FALSE TRUE
MSTRG.854.5 ENSG00000116885 HEK293_OSMI2_6hA HEK293_TMG_6hB OSCP1 protein_coding   10.26164 8.915207 7.692452 0.6216807 0.5438573 -0.2125679 0.4322842 0.6398668 0.1358436 0.3032395 0.07463585 -2.1557215 0.0395750 0.06806667 0.01783333 -0.05023333 0.518879762 0.002597646 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116885 E001 1.0177506 0.0158999721 0.5266550268   1 36415827 36416095 269 - 0.230 0.342 0.781
ENSG00000116885 E002 1.2979604 0.1363756232 0.8955588430   1 36417906 36417909 4 - 0.313 0.349 0.224
ENSG00000116885 E003 1.2979604 0.1363756232 0.8955588430   1 36417910 36417910 1 - 0.313 0.349 0.224
ENSG00000116885 E004 3.2511396 0.0088488930 0.9116084599 0.957959998 1 36417911 36417942 32 - 0.616 0.632 0.071
ENSG00000116885 E005 16.3519404 0.0023060727 0.3964880454 0.625542687 1 36417943 36418059 117 - 1.194 1.264 0.248
ENSG00000116885 E006 35.8579163 0.0010527623 0.5225722342 0.716747063 1 36418060 36418255 196 - 1.583 1.545 -0.128
ENSG00000116885 E007 27.8442462 0.0091801164 0.4740902071 0.682887360 1 36418991 36419054 64 - 1.481 1.429 -0.181
ENSG00000116885 E008 3.2446178 0.0328729750 0.1740107735 0.395887623 1 36419055 36419293 239 - 0.715 0.493 -0.985
ENSG00000116885 E009 1.2123728 0.0392419546 0.8501908636   1 36420333 36420475 143 - 0.378 0.341 -0.220
ENSG00000116885 E010 39.5712697 0.0016119594 0.7042622721 0.838309445 1 36420476 36420615 140 - 1.610 1.588 -0.072
ENSG00000116885 E011 2.2432950 0.0131954993 0.4366573725 0.656221323 1 36422002 36422149 148 - 0.438 0.567 0.629
ENSG00000116885 E012 30.7018994 0.0092468054 0.6896259499 0.828787692 1 36422150 36422219 70 - 1.504 1.479 -0.088
ENSG00000116885 E013 24.1254680 0.0136268759 0.8423441709 0.920790539 1 36422768 36422785 18 - 1.379 1.398 0.067
ENSG00000116885 E014 37.0376894 0.0118198525 0.7250213398 0.851129876 1 36422786 36422896 111 - 1.586 1.562 -0.082
ENSG00000116885 E015 33.5362025 0.0014549945 0.0266014187 0.117076505 1 36423363 36423466 104 - 1.598 1.465 -0.457
ENSG00000116885 E016 0.1426347 0.0312403509 0.4236363645   1 36423467 36423471 5 - 0.130 0.000 -8.640
ENSG00000116885 E017 10.9698443 0.0034394245 0.0002961233 0.003691445 1 36428299 36428475 177 - 0.817 1.204 1.428
ENSG00000116885 E018 36.5941191 0.0017947733 0.3058799679 0.546546930 1 36431802 36431860 59 - 1.537 1.595 0.199
ENSG00000116885 E019 26.6040067 0.0029835441 0.8744146912 0.938426849 1 36431861 36431882 22 - 1.444 1.432 -0.042
ENSG00000116885 E020 56.3405541 0.0007523857 0.9917679867 0.997612130 1 36432422 36432568 147 - 1.754 1.753 -0.001
ENSG00000116885 E021 28.2657897 0.0016912978 0.0990748794 0.280137001 1 36432569 36432589 21 - 1.519 1.412 -0.369
ENSG00000116885 E022 58.0979991 0.0029667808 0.6044363166 0.773179893 1 36438756 36438910 155 - 1.754 1.780 0.087
ENSG00000116885 E023 0.0000000       1 36438911 36439000 90 -      
ENSG00000116885 E024 0.0000000       1 36440819 36440975 157 -      
ENSG00000116885 E025 0.6542209 0.0193874923 0.8834213551   1 36444004 36444033 30 - 0.229 0.204 -0.220
ENSG00000116885 E026 1.0412158 0.0346991650 0.0822041812   1 36447813 36447887 75 - 0.130 0.445 2.359
ENSG00000116885 E027 45.8706753 0.0043112600 0.1438818085 0.353221375 1 36450258 36450451 194 - 1.621 1.704 0.283