ENSG00000116871

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373148 ENSG00000116871 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP7D1 protein_coding processed_transcript 57.48271 83.26091 31.57954 16.77189 2.810625 -1.398366 17.423990 23.712246 7.858712 5.803896 1.2273648 -1.5920413 0.26528333 0.28020000 0.24553333 -0.03466667 8.446608e-01 1.690159e-18 FALSE TRUE
ENST00000373150 ENSG00000116871 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP7D1 protein_coding protein_coding 57.48271 83.26091 31.57954 16.77189 2.810625 -1.398366 3.180679 4.466523 3.462219 1.067903 1.8530347 -0.3665208 0.05328333 0.05946667 0.11396667 0.05450000 1.000000e+00 1.690159e-18 FALSE TRUE
ENST00000474796 ENSG00000116871 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP7D1 protein_coding protein_coding 57.48271 83.26091 31.57954 16.77189 2.810625 -1.398366 21.515743 34.689813 8.280522 9.074436 0.8344670 -2.0653930 0.38159583 0.40383333 0.26676667 -0.13706667 3.006520e-01 1.690159e-18 FALSE TRUE
ENST00000530729 ENSG00000116871 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP7D1 protein_coding protein_coding 57.48271 83.26091 31.57954 16.77189 2.810625 -1.398366 1.695901 0.000000 5.663296 0.000000 1.8496869 9.1480433 0.04490000 0.00000000 0.17353333 0.17353333 1.690159e-18 1.690159e-18 FALSE FALSE
MSTRG.842.7 ENSG00000116871 HEK293_OSMI2_6hA HEK293_TMG_6hB MAP7D1 protein_coding   57.48271 83.26091 31.57954 16.77189 2.810625 -1.398366 7.576663 12.091050 2.785349 3.095352 0.4536573 -2.1140317 0.12599167 0.14146667 0.08876667 -0.05270000 3.235030e-01 1.690159e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116871 E001 0.8507255 0.1693146467 3.121195e-01   1 36155579 36155733 155 + 0.000 0.257 10.663
ENSG00000116871 E002 0.3032425 0.0274424043 1.000000e+00   1 36155783 36155950 168 + 0.000 0.120 11.653
ENSG00000116871 E003 0.3032425 0.0274424043 1.000000e+00   1 36155951 36155964 14 + 0.000 0.120 11.653
ENSG00000116871 E004 0.2617363 0.0475464676 1.000000e+00   1 36155965 36156057 93 + 0.000 0.120 11.425
ENSG00000116871 E005 2.1188784 0.0098227322 2.326669e-01 4.682384e-01 1 36156058 36156153 96 + 0.218 0.465 1.555
ENSG00000116871 E006 2.2497466 0.0094323013 1.929647e-01 4.207466e-01 1 36156154 36156159 6 + 0.218 0.488 1.670
ENSG00000116871 E007 16.1684969 0.0024178927 1.612440e-02 8.223901e-02 1 36156160 36156174 15 + 0.912 1.195 1.032
ENSG00000116871 E008 41.9355858 0.0031123792 3.673235e-04 4.409725e-03 1 36156175 36156197 23 + 1.299 1.588 0.996
ENSG00000116871 E009 42.8930492 0.0027181441 6.499949e-04 7.007623e-03 1 36156198 36156201 4 + 1.326 1.595 0.925
ENSG00000116871 E010 147.1492406 0.0013921367 5.678564e-04 6.289791e-03 1 36156202 36156463 262 + 1.956 2.101 0.489
ENSG00000116871 E011 0.1308682 0.0326491905 1.000000e+00   1 36157215 36157290 76 + 0.000 0.064 10.584
ENSG00000116871 E012 516.6073502 0.0009730267 4.737111e-05 7.943817e-04 1 36170971 36171315 345 + 2.695 2.594 -0.335
ENSG00000116871 E013 324.5306787 0.0002342852 1.415360e-05 2.833105e-04 1 36171513 36171581 69 + 2.498 2.392 -0.353
ENSG00000116871 E014 4.5803734 0.1945394871 4.826186e-01 6.888010e-01 1 36171582 36171823 242 + 0.791 0.628 -0.675
ENSG00000116871 E015 6.2555875 0.0859438848 9.619273e-01 9.829676e-01 1 36171968 36172463 496 + 0.794 0.766 -0.113
ENSG00000116871 E016 472.5082979 0.0001765168 2.023336e-04 2.700904e-03 1 36172464 36172627 164 + 2.638 2.562 -0.255
ENSG00000116871 E017 371.5816309 0.0002030663 1.668296e-01 3.863270e-01 1 36173364 36173478 115 + 2.503 2.469 -0.111
ENSG00000116871 E018 0.8403870 0.0184811707 3.048023e-01   1 36173479 36173479 1 + 0.362 0.170 -1.440
ENSG00000116871 E019 209.7908053 0.0025970481 8.935471e-02 2.625843e-01 1 36174898 36175008 111 + 2.282 2.213 -0.231
ENSG00000116871 E020 248.9105677 0.0006705834 5.830521e-01 7.590406e-01 1 36176199 36176321 123 + 2.290 2.306 0.052
ENSG00000116871 E021 114.9349296 0.0016072729 6.046519e-06 1.357354e-04 1 36176322 36176417 96 + 1.780 2.005 0.757
ENSG00000116871 E022 134.3118450 0.0058061486 4.735403e-10 2.924292e-08 1 36176418 36176581 164 + 1.704 2.087 1.287
ENSG00000116871 E023 87.5818819 0.0012988481 3.209989e-03 2.466205e-02 1 36176697 36176716 20 + 1.726 1.880 0.520
ENSG00000116871 E024 226.9903100 0.0033923765 9.132574e-01 9.587309e-01 1 36176717 36176805 89 + 2.263 2.258 -0.015
ENSG00000116871 E025 231.5384117 0.0053463317 2.779083e-01 5.179628e-01 1 36176806 36176842 37 + 2.315 2.253 -0.206
ENSG00000116871 E026 3.6607323 0.2441308423 1.794608e-01 4.032785e-01 1 36177469 36177574 106 + 0.842 0.493 -1.496
ENSG00000116871 E027 499.0550187 0.0041044293 8.589582e-01 9.298347e-01 1 36177873 36178201 329 + 2.613 2.594 -0.062
ENSG00000116871 E028 3.0119179 0.0105895553 7.288551e-01 8.535065e-01 1 36178411 36178418 8 + 0.471 0.531 0.296
ENSG00000116871 E029 90.4761444 0.0005821236 4.290502e-03 3.078918e-02 1 36178419 36178445 27 + 1.746 1.888 0.478
ENSG00000116871 E030 130.4381119 0.0004652816 1.441319e-04 2.029595e-03 1 36178446 36178470 25 + 1.888 2.047 0.536
ENSG00000116871 E031 333.6134491 0.0015773491 4.586287e-04 5.300392e-03 1 36178471 36178596 126 + 2.336 2.442 0.352
ENSG00000116871 E032 2.8450852 0.0086279142 9.024560e-02 2.642356e-01 1 36178597 36178684 88 + 0.218 0.569 2.056
ENSG00000116871 E033 464.4178529 0.0008682613 2.905505e-04 3.633978e-03 1 36178685 36178823 139 + 2.496 2.584 0.294
ENSG00000116871 E034 1.8876896 0.0118298589 8.925062e-01 9.478455e-01 1 36178824 36178920 97 + 0.362 0.387 0.144
ENSG00000116871 E035 425.8701718 0.0003658675 1.311533e-01 3.336440e-01 1 36178921 36179020 100 + 2.506 2.539 0.110
ENSG00000116871 E036 232.9560256 0.0002241818 9.089071e-01 9.565199e-01 1 36179021 36179025 5 + 2.271 2.273 0.008
ENSG00000116871 E037 2.5526243 0.2925231652 6.758148e-01 8.200590e-01 1 36179026 36179261 236 + 0.563 0.448 -0.558
ENSG00000116871 E038 386.8958532 0.0012671215 5.886233e-01 7.627748e-01 1 36179262 36179315 54 + 2.502 2.485 -0.059
ENSG00000116871 E039 4.9713776 0.5392636367 5.269750e-01 7.198327e-01 1 36179316 36179511 196 + 0.804 0.662 -0.582
ENSG00000116871 E040 31.1419421 0.0012063921 7.794406e-01 8.844156e-01 1 36179512 36179514 3 + 1.400 1.421 0.072
ENSG00000116871 E041 399.7237303 0.0024884128 8.648597e-01 9.330616e-01 1 36179515 36179557 43 + 2.510 2.499 -0.037
ENSG00000116871 E042 513.1733503 0.0019848840 1.919687e-01 4.193487e-01 1 36179666 36179756 91 + 2.643 2.602 -0.136
ENSG00000116871 E043 789.8930748 0.0011736226 1.173331e-02 6.536927e-02 1 36179874 36180067 194 + 2.845 2.786 -0.197
ENSG00000116871 E044 1030.2783303 0.0001032018 8.407626e-01 9.198669e-01 1 36180248 36180849 602 + 2.921 2.915 -0.017