ENSG00000116830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369466 ENSG00000116830 HEK293_OSMI2_6hA HEK293_TMG_6hB TTF2 protein_coding protein_coding 30.99517 17.27288 49.28841 1.67268 1.714277 1.512197 4.839968 3.6429344 6.229505 0.31939977 0.06804528 0.7723756 0.1778458 0.21316667 0.1266333 -0.08653333 0.04353502 0.03333651 FALSE TRUE
ENST00000427271 ENSG00000116830 HEK293_OSMI2_6hA HEK293_TMG_6hB TTF2 protein_coding protein_coding 30.99517 17.27288 49.28841 1.67268 1.714277 1.512197 2.997631 2.0133315 3.930850 0.17391580 0.46337351 0.9617740 0.1130375 0.11766667 0.0796000 -0.03806667 0.38624745 0.03333651 FALSE TRUE
ENST00000480701 ENSG00000116830 HEK293_OSMI2_6hA HEK293_TMG_6hB TTF2 protein_coding processed_transcript 30.99517 17.27288 49.28841 1.67268 1.714277 1.512197 3.651139 2.1927818 5.672122 0.34012188 0.21843944 1.3671031 0.1248125 0.13290000 0.1150667 -0.01783333 0.95697321 0.03333651   FALSE
MSTRG.1904.12 ENSG00000116830 HEK293_OSMI2_6hA HEK293_TMG_6hB TTF2 protein_coding   30.99517 17.27288 49.28841 1.67268 1.714277 1.512197 5.927591 4.1699410 9.463968 1.16214464 0.75837504 1.1804863 0.2008000 0.23303333 0.1914333 -0.04160000 0.90653584 0.03333651 FALSE TRUE
MSTRG.1904.13 ENSG00000116830 HEK293_OSMI2_6hA HEK293_TMG_6hB TTF2 protein_coding   30.99517 17.27288 49.28841 1.67268 1.714277 1.512197 1.879109 0.6240982 4.004572 0.09618887 0.41854181 2.6624679 0.0525875 0.03593333 0.0814000 0.04546667 0.03333651 0.03333651 FALSE TRUE
MSTRG.1904.6 ENSG00000116830 HEK293_OSMI2_6hA HEK293_TMG_6hB TTF2 protein_coding   30.99517 17.27288 49.28841 1.67268 1.714277 1.512197 10.212725 3.6905786 17.803328 0.56486400 0.20786589 2.2671343 0.2759292 0.21570000 0.3620667 0.14636667 0.10016272 0.03333651 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116830 E001 0.3206185 0.0274424043 5.027974e-01   1 117060101 117060311 211 + 0.158 0.000 -11.404
ENSG00000116830 E002 0.1426347 0.0323462394 1.000000e+00   1 117060312 117060313 2 + 0.086 0.000 -10.389
ENSG00000116830 E003 0.1426347 0.0323462394 1.000000e+00   1 117060314 117060314 1 + 0.086 0.000 -10.389
ENSG00000116830 E004 2.0961350 0.3858255339 9.529214e-01 9.784371e-01 1 117060315 117060325 11 + 0.483 0.450 -0.168
ENSG00000116830 E005 2.0961350 0.3858255339 9.529214e-01 9.784371e-01 1 117060326 117060328 3 + 0.483 0.450 -0.168
ENSG00000116830 E006 42.4920608 0.0072762673 1.809480e-04 2.459245e-03 1 117060329 117060361 33 + 1.682 1.409 -0.936
ENSG00000116830 E007 50.9506590 0.0091890369 3.508248e-04 4.247994e-03 1 117060362 117060374 13 + 1.756 1.496 -0.884
ENSG00000116830 E008 93.1670296 0.0009969013 1.848056e-03 1.604265e-02 1 117060455 117060557 103 + 1.983 1.859 -0.419
ENSG00000116830 E009 0.3559677 0.4863482449 6.446665e-01   1 117060558 117060561 4 + 0.161 0.000 -11.432
ENSG00000116830 E010 100.2113880 0.0066297801 4.105412e-02 1.574618e-01 1 117062387 117062473 87 + 2.009 1.908 -0.338
ENSG00000116830 E011 85.1863337 0.0102891677 7.389601e-02 2.325564e-01 1 117073661 117073727 67 + 1.939 1.838 -0.341
ENSG00000116830 E012 337.6045075 0.0012418516 1.141889e-08 5.285339e-07 1 117074870 117075294 425 + 2.541 2.394 -0.489
ENSG00000116830 E013 404.9757601 0.0010695739 1.224501e-05 2.498779e-04 1 117075295 117075859 565 + 2.609 2.510 -0.329
ENSG00000116830 E014 179.4230761 0.0013988681 1.146689e-02 6.427083e-02 1 117076180 117076294 115 + 2.250 2.172 -0.259
ENSG00000116830 E015 0.4349185 0.0217681645 1.000000e+00   1 117076295 117076389 95 + 0.158 0.169 0.118
ENSG00000116830 E016 218.8278877 0.0026484970 3.276161e-01 5.666811e-01 1 117076641 117076823 183 + 2.321 2.295 -0.088
ENSG00000116830 E017 12.3760412 0.0033029970 7.934856e-01 8.923781e-01 1 117077895 117077915 21 + 1.093 1.126 0.118
ENSG00000116830 E018 209.0006657 0.0012900767 1.564482e-01 3.715352e-01 1 117077916 117078043 128 + 2.304 2.267 -0.122
ENSG00000116830 E019 169.9771380 0.0015989245 4.134917e-03 2.992049e-02 1 117079568 117079649 82 + 2.231 2.139 -0.308
ENSG00000116830 E020 87.6696639 0.0005033005 1.808486e-04 2.458357e-03 1 117081828 117081830 3 + 1.963 1.811 -0.513
ENSG00000116830 E021 195.8760561 0.0002346620 1.721731e-05 3.363893e-04 1 117081831 117081947 117 + 2.298 2.184 -0.381
ENSG00000116830 E022 12.9643770 0.0049834598 6.443274e-04 6.955353e-03 1 117081948 117082031 84 + 1.212 0.826 -1.423
ENSG00000116830 E023 204.0288871 0.0004241729 1.211471e-02 6.691800e-02 1 117084018 117084168 151 + 2.302 2.238 -0.212
ENSG00000116830 E024 162.7620089 0.0003487566 5.452796e-01 7.328812e-01 1 117086417 117086522 106 + 2.189 2.178 -0.038
ENSG00000116830 E025 179.2076931 0.0002585131 1.403390e-01 3.480257e-01 1 117088801 117088982 182 + 2.209 2.258 0.163
ENSG00000116830 E026 174.3799463 0.0020213294 8.095656e-01 9.018995e-01 1 117090055 117090208 154 + 2.207 2.224 0.056
ENSG00000116830 E027 148.3626407 0.0011074784 7.780044e-01 8.835120e-01 1 117090532 117090623 92 + 2.144 2.141 -0.007
ENSG00000116830 E028 141.4485868 0.0003720373 9.576805e-01 9.806891e-01 1 117091328 117091410 83 + 2.122 2.127 0.019
ENSG00000116830 E029 209.8502162 0.0012738812 3.962999e-01 6.253865e-01 1 117091817 117091950 134 + 2.282 2.314 0.107
ENSG00000116830 E030 184.8413879 0.0006055780 7.639125e-01 8.750160e-01 1 117092731 117092786 56 + 2.232 2.248 0.053
ENSG00000116830 E031 248.3819408 0.0003003023 4.003621e-01 6.285832e-01 1 117092787 117092901 115 + 2.359 2.386 0.092
ENSG00000116830 E032 134.1391013 0.0003042092 6.409348e-01 7.974845e-01 1 117095309 117095324 16 + 2.093 2.115 0.075
ENSG00000116830 E033 163.8882100 0.0004531395 5.781725e-01 7.559545e-01 1 117095325 117095367 43 + 2.191 2.181 -0.034
ENSG00000116830 E034 115.7720535 0.0043611726 4.168939e-01 6.413097e-01 1 117096149 117096170 22 + 2.050 2.018 -0.106
ENSG00000116830 E035 238.0245910 0.0002183203 9.938484e-01 9.985524e-01 1 117096171 117096299 129 + 2.347 2.354 0.024
ENSG00000116830 E036 207.0002231 0.0018899877 2.287727e-01 4.637801e-01 1 117097351 117097433 83 + 2.272 2.319 0.155
ENSG00000116830 E037 18.0906193 0.0111648900 8.996176e-01 9.517024e-01 1 117098206 117098238 33 + 1.253 1.246 -0.026
ENSG00000116830 E038 63.3444882 0.0431391388 8.202634e-01 9.082525e-01 1 117098246 117098832 587 + 1.781 1.774 -0.024
ENSG00000116830 E039 187.4856029 0.0026044155 1.666522e-01 3.860912e-01 1 117098833 117098907 75 + 2.226 2.283 0.190
ENSG00000116830 E040 264.4431305 0.0013320964 2.618173e-02 1.158665e-01 1 117101380 117101562 183 + 2.370 2.440 0.233
ENSG00000116830 E041 382.0805966 0.0002009048 2.992673e-07 9.837163e-06 1 117101563 117102193 631 + 2.515 2.621 0.352
ENSG00000116830 E042 139.1148201 0.0008542830 1.046271e-02 6.012684e-02 1 117102194 117102266 73 + 2.082 2.175 0.310
ENSG00000116830 E043 233.2051333 0.0014731232 2.592933e-06 6.538079e-05 1 117102267 117102995 729 + 2.285 2.430 0.484
ENSG00000116830 E044 191.2606403 0.0078576251 7.794590e-04 8.110414e-03 1 117102996 117104721 1726 + 2.189 2.362 0.577
ENSG00000116830 E045 19.8261077 0.0580817415 2.907271e-02 1.245576e-01 1 117104722 117104793 72 + 1.156 1.476 1.118
ENSG00000116830 E046 291.5389535 0.0048345182 8.604940e-10 5.091696e-08 1 117104794 117107474 2681 + 2.341 2.584 0.812
ENSG00000116830 E047 0.3228314 0.3941447585 6.232178e-01   1 117118047 117118159 113 + 0.158 0.000 -11.397
ENSG00000116830 E048 2.0949016 0.0102674187 1.814309e-01 4.058897e-01 1 117118160 117119290 1131 + 0.532 0.290 -1.340
ENSG00000116830 E049 1.7092284 0.0676699457 1.469806e-02 7.695368e-02 1 117120794 117121806 1013 + 0.219 0.679 2.530
ENSG00000116830 E050 0.8156366 0.0166930332 7.070590e-01   1 117139815 117139877 63 + 0.219 0.290 0.534