ENSG00000116791

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340866 ENSG00000116791 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZ protein_coding protein_coding 10.19567 2.81252 19.40491 0.3711185 0.3036982 2.78211 7.2369087 2.01822048 14.1455315 0.37867905 0.51242575 2.8030795 0.70657500 0.70760000 0.72850000 0.020900000 0.94924395 0.01662725 FALSE  
ENST00000370871 ENSG00000116791 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZ protein_coding protein_coding 10.19567 2.81252 19.40491 0.3711185 0.3036982 2.78211 0.6744290 0.17009802 1.5723430 0.09468177 0.21413042 3.1352082 0.05467917 0.07223333 0.08106667 0.008833333 0.91145577 0.01662725 FALSE  
ENST00000417775 ENSG00000116791 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZ protein_coding protein_coding 10.19567 2.81252 19.40491 0.3711185 0.3036982 2.78211 0.7388417 0.28061569 0.5293453 0.14660982 0.52934529 0.8920966 0.09739167 0.08833333 0.02803333 -0.060300000 0.57637324 0.01662725 FALSE  
ENST00000492102 ENSG00000116791 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZ protein_coding processed_transcript 10.19567 2.81252 19.40491 0.3711185 0.3036982 2.78211 0.2549644 0.21560724 0.3087617 0.04148328 0.03429166 0.4986649 0.03934583 0.08270000 0.01596667 -0.066733333 0.01662725 0.01662725    
MSTRG.1423.2 ENSG00000116791 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZ protein_coding   10.19567 2.81252 19.40491 0.3711185 0.3036982 2.78211 0.7908036 0.07305836 2.2313678 0.03698842 0.27204041 4.7541103 0.05699167 0.03016667 0.11456667 0.084400000 0.05310335 0.01662725 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116791 E001 1.6480991 0.0286848665 3.225865e-01 0.5619674017 1 74702108 74702286 179 - 0.319 0.517 1.074
ENSG00000116791 E002 4.4237913 0.0099262528 1.978340e-01 0.4269399680 1 74704855 74704948 94 - 0.657 0.403 -1.211
ENSG00000116791 E003 7.6234769 0.0036465754 3.284691e-01 0.5674825457 1 74704949 74705060 112 - 0.836 0.683 -0.616
ENSG00000116791 E004 0.9722506 0.0565379621 9.320639e-01   1 74705482 74705485 4 - 0.225 0.247 0.177
ENSG00000116791 E005 0.8521535 0.0839003318 1.994497e-01   1 74705486 74705487 2 - 0.148 0.406 1.929
ENSG00000116791 E006 0.8521535 0.0839003318 1.994497e-01   1 74705488 74705489 2 - 0.148 0.406 1.929
ENSG00000116791 E007 108.5137463 0.0186820215 5.797213e-01 0.7570282330 1 74705490 74705971 482 - 1.887 1.945 0.195
ENSG00000116791 E008 116.6170554 0.0003932147 1.115005e-01 0.3015135196 1 74705972 74706258 287 - 1.917 1.988 0.240
ENSG00000116791 E009 103.1577344 0.0006963122 1.748882e-03 0.0153631486 1 74706259 74706457 199 - 1.854 1.995 0.472
ENSG00000116791 E010 91.3044505 0.0016752156 5.206793e-01 0.7153816544 1 74706899 74706994 96 - 1.820 1.857 0.127
ENSG00000116791 E011 2.6786908 0.1527310140 3.379416e-04 0.0041193116 1 74706995 74707102 108 - 0.226 0.981 3.650
ENSG00000116791 E012 51.3450925 0.0008954959 6.612367e-01 0.8107135034 1 74707103 74707104 2 - 1.582 1.558 -0.081
ENSG00000116791 E013 78.8204758 0.0005018508 3.493847e-01 0.5866908899 1 74707105 74707204 100 - 1.769 1.724 -0.152
ENSG00000116791 E014 10.0441495 0.0063951764 1.527946e-05 0.0003029898 1 74707205 74708827 1623 - 0.790 1.287 1.829
ENSG00000116791 E015 47.9035451 0.0009146120 7.340383e-02 0.2316089812 1 74710098 74710108 11 - 1.568 1.443 -0.427
ENSG00000116791 E016 102.5703065 0.0005830661 4.205405e-02 0.1600677858 1 74710109 74710247 139 - 1.887 1.793 -0.316
ENSG00000116791 E017 63.0026080 0.0007217050 3.038760e-02 0.1285116390 1 74714579 74714630 52 - 1.682 1.549 -0.454
ENSG00000116791 E018 102.5588161 0.0004453771 2.602101e-01 0.4991716245 1 74719209 74719372 164 - 1.882 1.834 -0.161
ENSG00000116791 E019 90.6044021 0.0005727979 2.724972e-01 0.5123423061 1 74723118 74723270 153 - 1.827 1.777 -0.170
ENSG00000116791 E020 85.5587895 0.0006326336 4.116243e-01 0.6372742476 1 74724711 74724834 124 - 1.803 1.766 -0.125
ENSG00000116791 E021 9.1604689 0.0038759516 7.529133e-01 0.8684919328 1 74730382 74730420 39 - 0.892 0.852 -0.154
ENSG00000116791 E022 0.1308682 0.0326491905 6.777890e-02   1 74732767 74732955 189 - 0.000 0.246 11.042
ENSG00000116791 E023 59.8893260 0.0016533413 7.243802e-01 0.8507713003 1 74732956 74733408 453 - 1.650 1.634 -0.056