ENSG00000116786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375793 ENSG00000116786 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM2 protein_coding protein_coding 40.25346 68.15674 18.79384 12.99899 0.9189637 -1.85804 14.704750 28.8418434 8.99248557 4.7245337 0.52103682 -1.6802682 0.37825417 0.431000000 0.4790333 4.803333e-02 7.839796e-01 2.098787e-13 FALSE TRUE
ENST00000375799 ENSG00000116786 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM2 protein_coding protein_coding 40.25346 68.15674 18.79384 12.99899 0.9189637 -1.85804 2.042296 0.3632129 0.08794264 0.1954068 0.08794264 -1.9299898 0.06744167 0.004466667 0.0045000 3.333333e-05 9.199248e-01 2.098787e-13 FALSE TRUE
ENST00000477849 ENSG00000116786 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM2 protein_coding processed_transcript 40.25346 68.15674 18.79384 12.99899 0.9189637 -1.85804 8.145473 13.1801220 1.43083796 3.3693462 0.55474091 -3.1944779 0.16115000 0.187100000 0.0750000 -1.121000e-01 1.531463e-01 2.098787e-13 FALSE TRUE
ENST00000642363 ENSG00000116786 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM2 protein_coding protein_coding 40.25346 68.15674 18.79384 12.99899 0.9189637 -1.85804 1.628104 5.4807648 0.00000000 0.9972833 0.00000000 -9.1008633 0.02995000 0.083033333 0.0000000 -8.303333e-02 2.098787e-13 2.098787e-13 FALSE TRUE
MSTRG.366.3 ENSG00000116786 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM2 protein_coding   40.25346 68.15674 18.79384 12.99899 0.9189637 -1.85804 7.596773 8.6709762 4.59401050 2.5944997 0.58460490 -0.9149662 0.21287917 0.120333333 0.2436667 1.233333e-01 7.606899e-02 2.098787e-13 FALSE TRUE
MSTRG.366.5 ENSG00000116786 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM2 protein_coding   40.25346 68.15674 18.79384 12.99899 0.9189637 -1.85804 5.906945 11.3373785 3.68856608 1.7960853 0.28519020 -1.6173211 0.14335417 0.169833333 0.1978000 2.796667e-02 8.230564e-01 2.098787e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116786 E001 0.6258862 0.0193874923 7.633259e-01   1 15684320 15684389 70 + 0.214 0.173 -0.377
ENSG00000116786 E002 3.5927814 0.1304273350 7.917025e-01 8.914385e-01 1 15684390 15684537 148 + 0.621 0.568 -0.234
ENSG00000116786 E003 5.9155439 0.1942022227 4.470290e-01 6.634837e-01 1 15684538 15684540 3 + 0.546 0.787 1.026
ENSG00000116786 E004 20.0385404 0.0155960486 6.112343e-01 7.777523e-01 1 15684541 15684555 15 + 1.156 1.246 0.317
ENSG00000116786 E005 97.2031117 0.0040979109 8.615709e-01 9.311866e-01 1 15684556 15684618 63 + 1.878 1.905 0.093
ENSG00000116786 E006 189.3169297 0.0005637280 3.974436e-01 6.263073e-01 1 15716237 15716343 107 + 2.184 2.192 0.025
ENSG00000116786 E007 221.3007560 0.0003103538 9.188585e-03 5.465912e-02 1 15716707 15716816 110 + 2.292 2.251 -0.138
ENSG00000116786 E008 204.0584797 0.0003539953 1.706696e-05 3.339127e-04 1 15717893 15717992 100 + 2.298 2.204 -0.314
ENSG00000116786 E009 238.5018539 0.0002253394 1.068390e-09 6.201357e-08 1 15718538 15718625 88 + 2.391 2.262 -0.433
ENSG00000116786 E010 361.2640601 0.0001529732 1.356293e-07 4.892306e-06 1 15719734 15719920 187 + 2.534 2.452 -0.274
ENSG00000116786 E011 64.5790131 0.0010644560 1.877375e-02 9.163643e-02 1 15721329 15721388 60 + 1.578 1.753 0.593
ENSG00000116786 E012 349.4446089 0.0012814415 6.389538e-03 4.163497e-02 1 15725317 15725545 229 + 2.489 2.445 -0.148
ENSG00000116786 E013 174.1978302 0.0012359455 1.981344e-02 9.525265e-02 1 15727014 15727068 55 + 2.195 2.142 -0.175
ENSG00000116786 E014 204.9322787 0.0025725846 7.911834e-01 8.911377e-01 1 15727069 15727191 123 + 2.204 2.227 0.075
ENSG00000116786 E015 779.0495990 0.0038857777 7.122021e-01 8.432036e-01 1 15727192 15727832 641 + 2.780 2.801 0.069
ENSG00000116786 E016 289.5843069 0.0026025868 1.588661e-01 3.750576e-01 1 15728079 15728148 70 + 2.385 2.366 -0.064
ENSG00000116786 E017 280.2326681 0.0018975646 4.466763e-01 6.631979e-01 1 15728267 15728357 91 + 2.312 2.366 0.181
ENSG00000116786 E018 237.0974985 0.0007744415 6.204278e-01 7.841041e-01 1 15728669 15728733 65 + 2.271 2.288 0.056
ENSG00000116786 E019 238.4639940 0.0002829247 4.313972e-01 6.522366e-01 1 15729102 15729190 89 + 2.281 2.293 0.041
ENSG00000116786 E020 242.8423579 0.0005615032 1.195027e-02 6.624332e-02 1 15729797 15729844 48 + 2.328 2.289 -0.129
ENSG00000116786 E021 330.8840474 0.0002962610 1.566271e-02 8.058803e-02 1 15729845 15729929 85 + 2.449 2.424 -0.084
ENSG00000116786 E022 451.1895885 0.0004958454 1.366982e-01 3.424523e-01 1 15730532 15730722 191 + 2.563 2.562 -0.003
ENSG00000116786 E023 281.6299868 0.0001857396 8.378958e-02 2.523569e-01 1 15731192 15731257 66 + 2.295 2.377 0.273
ENSG00000116786 E024 254.4574091 0.0002367621 5.948604e-03 3.948908e-02 1 15731889 15731949 61 + 2.226 2.341 0.384
ENSG00000116786 E025 312.2962403 0.0436393270 2.246706e-01 4.590106e-01 1 15731950 15732048 99 + 2.297 2.423 0.422
ENSG00000116786 E026 428.6130068 0.4251658365 2.629914e-01 5.021926e-01 1 15732350 15732529 180 + 2.354 2.573 0.732
ENSG00000116786 E027 144.6768147 0.2380312103 2.312652e-01 4.666050e-01 1 15732612 15732614 3 + 1.903 2.102 0.665
ENSG00000116786 E028 363.0792090 0.0226191527 7.870769e-02 2.422059e-01 1 15732615 15732728 114 + 2.344 2.492 0.494
ENSG00000116786 E029 1220.1127020 0.0024636629 1.588635e-02 8.136474e-02 1 15733797 15734769 973 + 2.914 3.009 0.315