ENSG00000116754

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370949 ENSG00000116754 HEK293_OSMI2_6hA HEK293_TMG_6hB SRSF11 protein_coding protein_coding 110.8548 46.96802 181.6887 3.849382 0.5962557 1.951491 22.629726 9.9902833 32.00408 1.80353776 1.5955134 1.678666 0.20801667 0.219833333 0.17610000 -0.043733333 8.929953e-01 4.291085e-06 FALSE  
ENST00000370951 ENSG00000116754 HEK293_OSMI2_6hA HEK293_TMG_6hB SRSF11 protein_coding protein_coding 110.8548 46.96802 181.6887 3.849382 0.5962557 1.951491 19.601432 7.3122231 37.20322 0.38039570 0.8376019 2.345461 0.16040000 0.159066667 0.20476667 0.045700000 5.812634e-01 4.291085e-06 FALSE  
ENST00000463116 ENSG00000116754 HEK293_OSMI2_6hA HEK293_TMG_6hB SRSF11 protein_coding processed_transcript 110.8548 46.96802 181.6887 3.849382 0.5962557 1.951491 7.220752 2.8386361 12.87197 0.92122163 0.5634098 2.177010 0.06274583 0.058333333 0.07086667 0.012533333 8.210185e-01 4.291085e-06    
ENST00000463877 ENSG00000116754 HEK293_OSMI2_6hA HEK293_TMG_6hB SRSF11 protein_coding processed_transcript 110.8548 46.96802 181.6887 3.849382 0.5962557 1.951491 25.035519 11.7479411 36.81433 2.16852056 0.3936379 1.647024 0.23311667 0.247366667 0.20260000 -0.044766667 7.311514e-01 4.291085e-06 FALSE  
ENST00000484162 ENSG00000116754 HEK293_OSMI2_6hA HEK293_TMG_6hB SRSF11 protein_coding retained_intron 110.8548 46.96802 181.6887 3.849382 0.5962557 1.951491 10.196064 4.5777408 17.77170 1.35548553 0.8785764 1.954538 0.09022917 0.094133333 0.09786667 0.003733333 9.709444e-01 4.291085e-06 FALSE  
ENST00000486667 ENSG00000116754 HEK293_OSMI2_6hA HEK293_TMG_6hB SRSF11 protein_coding processed_transcript 110.8548 46.96802 181.6887 3.849382 0.5962557 1.951491 5.129383 0.1391568 12.29999 0.07841955 1.9753239 6.366856 0.03064583 0.002866667 0.06763333 0.064766667 4.291085e-06 4.291085e-06 FALSE  
ENST00000690370 ENSG00000116754 HEK293_OSMI2_6hA HEK293_TMG_6hB SRSF11 protein_coding retained_intron 110.8548 46.96802 181.6887 3.849382 0.5962557 1.951491 8.376686 3.5596624 16.18526 0.42504730 0.1960017 2.181712 0.07297500 0.075633333 0.08906667 0.013433333 7.221708e-01 4.291085e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116754 E001 6.240995 0.1525253599 3.632732e-01 5.983487e-01 1 70205682 70205687 6 + 0.854 0.643 -0.858
ENSG00000116754 E002 11.757596 0.0657913014 3.824225e-01 6.141952e-01 1 70205688 70205697 10 + 1.079 0.932 -0.543
ENSG00000116754 E003 32.065382 0.0014467825 2.531077e-02 1.131621e-01 1 70205698 70205716 19 + 1.488 1.338 -0.519
ENSG00000116754 E004 37.045336 0.0010762628 1.216852e-02 6.714412e-02 1 70205717 70205723 7 + 1.550 1.392 -0.543
ENSG00000116754 E005 97.994037 0.0003744123 9.344775e-02 2.701021e-01 1 70205724 70205780 57 + 1.941 1.890 -0.169
ENSG00000116754 E006 2.811261 0.0349107074 2.282964e-01 4.632459e-01 1 70221370 70221379 10 + 0.474 0.701 1.023
ENSG00000116754 E007 10.410069 0.0101130526 1.185293e-01 3.134383e-01 1 70221380 70221395 16 + 0.951 1.152 0.732
ENSG00000116754 E008 12.218588 0.0307034690 9.595622e-02 2.746737e-01 1 70221396 70221400 5 + 1.000 1.240 0.866
ENSG00000116754 E009 31.751071 0.0154317663 1.958926e-02 9.451675e-02 1 70221401 70221468 68 + 1.389 1.617 0.782
ENSG00000116754 E010 31.903245 0.0080498535 1.257058e-02 6.872179e-02 1 70221469 70221479 11 + 1.395 1.608 0.730
ENSG00000116754 E011 156.392864 0.0005728247 1.148896e-03 1.103932e-02 1 70221480 70221611 132 + 2.098 2.225 0.426
ENSG00000116754 E012 136.413107 0.0003075456 6.270737e-01 7.885867e-01 1 70221612 70221614 3 + 2.063 2.101 0.127
ENSG00000116754 E013 302.902620 0.0001982520 1.160640e-01 3.092847e-01 1 70221615 70221723 109 + 2.401 2.459 0.192
ENSG00000116754 E014 525.877196 0.0001897097 4.784223e-01 6.860296e-01 1 70221724 70221839 116 + 2.652 2.660 0.024
ENSG00000116754 E015 11.588061 0.0032082772 1.519171e-03 1.374416e-02 1 70222766 70222798 33 + 1.105 0.703 -1.537
ENSG00000116754 E016 475.758691 0.0003004972 1.857270e-03 1.610699e-02 1 70228422 70228464 43 + 2.620 2.576 -0.145
ENSG00000116754 E017 701.163300 0.0011349714 2.205904e-03 1.843932e-02 1 70228465 70228555 91 + 2.791 2.740 -0.170
ENSG00000116754 E018 144.683159 0.0221771419 1.016506e-01 2.847417e-01 1 70228556 70228735 180 + 2.050 2.215 0.553
ENSG00000116754 E019 103.337149 0.0480267627 5.090756e-01 7.072088e-01 1 70230064 70230277 214 + 1.956 1.938 -0.059
ENSG00000116754 E020 178.861583 0.0328483418 5.531345e-01 7.384944e-01 1 70230278 70230556 279 + 2.190 2.182 -0.025
ENSG00000116754 E021 88.757861 0.0126316605 1.019572e-01 2.853018e-01 1 70230557 70230618 62 + 1.847 1.988 0.474
ENSG00000116754 E022 230.985041 0.0445609598 2.938961e-01 5.345492e-01 1 70230619 70231094 476 + 2.310 2.262 -0.163
ENSG00000116754 E023 113.124382 0.0224839709 1.819369e-01 4.065190e-01 1 70231095 70231159 65 + 1.950 2.098 0.498
ENSG00000116754 E024 102.776333 0.0185179973 4.473552e-01 6.637764e-01 1 70231160 70231203 44 + 1.927 2.012 0.287
ENSG00000116754 E025 89.031625 0.0224594188 5.059740e-01 7.049125e-01 1 70231204 70231257 54 + 1.893 1.866 -0.093
ENSG00000116754 E026 193.076191 0.0287842825 4.669976e-01 6.780399e-01 1 70231258 70231547 290 + 2.225 2.209 -0.052
ENSG00000116754 E027 208.283577 0.0120710914 9.448910e-01 9.747554e-01 1 70231548 70231858 311 + 2.245 2.281 0.119
ENSG00000116754 E028 171.081340 0.0170223715 4.071783e-02 1.565857e-01 1 70231859 70231975 117 + 2.117 2.300 0.610
ENSG00000116754 E029 162.904570 0.0083141899 1.120599e-02 6.321744e-02 1 70231976 70232267 292 + 2.173 2.054 -0.398
ENSG00000116754 E030 676.791826 0.0018525149 1.570068e-03 1.411133e-02 1 70232268 70232377 110 + 2.780 2.718 -0.207
ENSG00000116754 E031 623.958706 0.0013364792 3.034778e-04 3.764335e-03 1 70234696 70234788 93 + 2.746 2.678 -0.224
ENSG00000116754 E032 367.075120 0.0004788044 4.650194e-03 3.273545e-02 1 70235501 70235550 50 + 2.512 2.464 -0.157
ENSG00000116754 E033 720.490062 0.0003948790 4.185618e-06 9.875163e-05 1 70237425 70237552 128 + 2.807 2.744 -0.207
ENSG00000116754 E034 653.363834 0.0001303316 1.436744e-06 3.898262e-05 1 70239439 70239520 82 + 2.763 2.703 -0.200
ENSG00000116754 E035 812.627676 0.0013097332 7.040537e-02 2.255159e-01 1 70244684 70244815 132 + 2.850 2.831 -0.063
ENSG00000116754 E036 3.034919 0.0202601583 8.355780e-02 2.518867e-01 1 70246730 70246817 88 + 0.449 0.750 1.353
ENSG00000116754 E037 609.245845 0.0023021894 9.722374e-01 9.880922e-01 1 70246818 70246907 90 + 2.715 2.737 0.074
ENSG00000116754 E038 22.949249 0.0078896775 1.742167e-01 3.961438e-01 1 70247117 70247149 33 + 1.277 1.420 0.497
ENSG00000116754 E039 89.826224 0.0062416367 1.474946e-02 7.714118e-02 1 70248394 70249741 1348 + 1.917 1.795 -0.412
ENSG00000116754 E040 22.910821 0.0017506046 2.353820e-01 4.712970e-01 1 70249742 70249930 189 + 1.330 1.249 -0.286
ENSG00000116754 E041 21.536915 0.0238452573 3.000212e-01 5.404225e-01 1 70249931 70249951 21 + 1.312 1.214 -0.345
ENSG00000116754 E042 691.137096 0.0024558998 2.264585e-01 4.611697e-01 1 70249952 70250047 96 + 2.761 2.816 0.183
ENSG00000116754 E043 4.797836 0.0066369464 9.004515e-01 9.520859e-01 1 70250048 70250364 317 + 0.712 0.749 0.151
ENSG00000116754 E044 743.521828 0.0006163285 5.958729e-06 1.341014e-04 1 70250365 70250503 139 + 2.779 2.883 0.347
ENSG00000116754 E045 220.823669 0.0030890336 1.184630e-04 1.720348e-03 1 70250608 70250610 3 + 2.232 2.400 0.560
ENSG00000116754 E046 3480.756413 0.0065093024 7.362775e-02 2.320138e-01 1 70250611 70253052 2442 + 3.458 3.524 0.217