ENSG00000116731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311066 ENSG00000116731 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM2 protein_coding protein_coding 9.104141 9.924757 9.247376 1.277625 0.3900529 -0.1018813 0.6228150 0.0292992 0.4445402 0.02929920 0.23918616 3.53183609 0.06602917 0.002566667 0.04610000 0.04353333 0.515697870 0.004059365 FALSE TRUE
ENST00000413440 ENSG00000116731 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM2 protein_coding protein_coding 9.104141 9.924757 9.247376 1.277625 0.3900529 -0.1018813 4.5545628 4.7856413 5.0823112 0.73897954 0.73685349 0.08659685 0.49857917 0.478500000 0.54536667 0.06686667 0.803885588 0.004059365 FALSE TRUE
ENST00000505823 ENSG00000116731 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM2 protein_coding protein_coding 9.104141 9.924757 9.247376 1.277625 0.3900529 -0.1018813 1.4714983 2.2039674 0.5164745 0.43637178 0.17598339 -2.07219838 0.16367917 0.217866667 0.05763333 -0.16023333 0.021227076 0.004059365 FALSE FALSE
MSTRG.340.5 ENSG00000116731 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM2 protein_coding   9.104141 9.924757 9.247376 1.277625 0.3900529 -0.1018813 0.8495914 0.8611255 1.9232368 0.19466270 0.04426026 1.15006595 0.09220000 0.084833333 0.20910000 0.12426667 0.004059365 0.004059365 FALSE TRUE
MSTRG.340.6 ENSG00000116731 HEK293_OSMI2_6hA HEK293_TMG_6hB PRDM2 protein_coding   9.104141 9.924757 9.247376 1.277625 0.3900529 -0.1018813 0.7149882 1.7933130 0.4154602 0.08929248 0.22850267 -2.08355374 0.07924167 0.186733333 0.04303333 -0.14370000 0.304634883 0.004059365 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116731 E001 0.0000000       1 13700188 13700197 10 +      
ENSG00000116731 E002 0.1426347 0.032788729 0.333281183   1 13700198 13700221 24 + 0.140 0.000 -21.004
ENSG00000116731 E003 0.6600180 0.594189901 0.038924893   1 13700222 13700229 8 + 0.405 0.000 -23.028
ENSG00000116731 E004 0.9217543 0.550566952 0.203949644   1 13700230 13700239 10 + 0.405 0.182 -1.570
ENSG00000116731 E005 2.9082575 0.385843366 0.201084968 0.43105264 1 13700240 13700300 61 + 0.713 0.487 -1.010
ENSG00000116731 E006 0.3641499 0.040622424 0.877590434   1 13704855 13705645 791 + 0.140 0.106 -0.465
ENSG00000116731 E007 2.1466313 0.493082970 0.090691003 0.26505158 1 13715541 13715614 74 + 0.687 0.263 -2.215
ENSG00000116731 E008 5.3338134 0.701113538 0.182303178 0.40700540 1 13731000 13731017 18 + 0.974 0.610 -1.457
ENSG00000116731 E009 13.8092242 0.345499856 0.251157427 0.48923296 1 13731018 13731117 100 + 1.277 1.063 -0.761
ENSG00000116731 E010 15.1621928 0.319880430 0.192985610 0.42077450 1 13732779 13732855 77 + 1.326 1.087 -0.846
ENSG00000116731 E011 9.6305897 0.212329868 0.153458122 0.36727999 1 13732856 13732882 27 + 1.130 0.924 -0.756
ENSG00000116731 E012 0.0000000       1 13738750 13738784 35 +      
ENSG00000116731 E013 0.0000000       1 13738785 13738940 156 +      
ENSG00000116731 E014 17.0148229 0.325418928 0.355619224 0.59221625 1 13742005 13742157 153 + 1.319 1.191 -0.449
ENSG00000116731 E015 9.0342377 0.350883670 0.339835235 0.57781200 1 13749361 13749402 42 + 1.066 0.931 -0.502
ENSG00000116731 E016 8.0903058 0.246486426 0.398205007 0.62682780 1 13749403 13749414 12 + 0.985 0.919 -0.247
ENSG00000116731 E017 8.0903058 0.246486426 0.398205007 0.62682780 1 13749415 13749423 9 + 0.985 0.919 -0.247
ENSG00000116731 E018 7.8578318 0.226946822 0.296898088 0.53735738 1 13749424 13749434 11 + 1.001 0.885 -0.435
ENSG00000116731 E019 9.3537426 0.117326255 0.184844657 0.41028459 1 13749435 13749435 1 + 1.089 0.935 -0.566
ENSG00000116731 E020 27.0929301 0.078177654 0.694761181 0.83213268 1 13749436 13749487 52 + 1.422 1.458 0.126
ENSG00000116731 E021 0.1779838 1.058392132 0.388830819   1 13769039 13769117 79 + 0.143 0.000 -21.049
ENSG00000116731 E022 0.9147398 0.630852784 0.107728258   1 13769118 13769173 56 + 0.459 0.102 -2.829
ENSG00000116731 E023 1.0401159 1.312970911 0.449469291   1 13771726 13772214 489 + 0.416 0.195 -1.502
ENSG00000116731 E024 34.9212978 0.022054230 0.150200912 0.36264280 1 13773078 13773188 111 + 1.603 1.510 -0.318
ENSG00000116731 E025 0.8922317 0.649302324 0.242355222   1 13773189 13773671 483 + 0.000 0.389 22.433
ENSG00000116731 E026 650.2197248 1.495314346 0.739458352 0.86007740 1 13778418 13782831 4414 + 2.840 2.783 -0.189
ENSG00000116731 E027 188.0899837 0.421155634 0.215265813 0.44781884 1 13786515 13788079 1565 + 2.189 2.319 0.435
ENSG00000116731 E028 33.8124570 0.001646095 0.001516771 0.01373408 1 13816427 13816570 144 + 1.409 1.613 0.700
ENSG00000116731 E029 193.6447349 0.180991995 0.020088689 0.09618440 1 13823159 13825079 1921 + 2.085 2.383 0.997