ENSG00000116679

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367497 ENSG00000116679 HEK293_OSMI2_6hA HEK293_TMG_6hB IVNS1ABP protein_coding protein_coding 23.07795 13.23506 32.97683 2.34542 0.4984862 1.316436 1.1178915 0.1862008 2.675105 0.10238436 0.6779455 3.77457589 0.04036250 0.01456667 0.0807000 0.06613333 1.709654e-01 9.570269e-16 FALSE TRUE
ENST00000422754 ENSG00000116679 HEK293_OSMI2_6hA HEK293_TMG_6hB IVNS1ABP protein_coding protein_coding 23.07795 13.23506 32.97683 2.34542 0.4984862 1.316436 1.5413075 0.4526057 3.208622 0.28122920 0.3438853 2.79858814 0.06235417 0.04370000 0.0972000 0.05350000 5.781596e-01 9.570269e-16 FALSE TRUE
ENST00000459929 ENSG00000116679 HEK293_OSMI2_6hA HEK293_TMG_6hB IVNS1ABP protein_coding processed_transcript 23.07795 13.23506 32.97683 2.34542 0.4984862 1.316436 0.4844376 0.9132472 0.000000 0.15957824 0.0000000 -6.52864510 0.03214167 0.07016667 0.0000000 -0.07016667 9.570269e-16 9.570269e-16 FALSE TRUE
ENST00000475046 ENSG00000116679 HEK293_OSMI2_6hA HEK293_TMG_6hB IVNS1ABP protein_coding retained_intron 23.07795 13.23506 32.97683 2.34542 0.4984862 1.316436 7.2271231 5.0030300 7.291654 1.09539729 0.7146178 0.54254036 0.33907500 0.37123333 0.2218000 -0.14943333 1.107031e-01 9.570269e-16 FALSE TRUE
ENST00000480769 ENSG00000116679 HEK293_OSMI2_6hA HEK293_TMG_6hB IVNS1ABP protein_coding retained_intron 23.07795 13.23506 32.97683 2.34542 0.4984862 1.316436 5.5396769 2.9009258 9.270903 0.46989386 0.5153678 1.67278713 0.23450417 0.22333333 0.2809667 0.05763333 5.802923e-01 9.570269e-16 FALSE TRUE
MSTRG.2748.4 ENSG00000116679 HEK293_OSMI2_6hA HEK293_TMG_6hB IVNS1ABP protein_coding   23.07795 13.23506 32.97683 2.34542 0.4984862 1.316436 4.2776525 3.4124752 3.566135 0.92222814 0.3520966 0.06336113 0.18971667 0.24753333 0.1078667 -0.13966667 1.367561e-02 9.570269e-16 FALSE TRUE
MSTRG.2748.5 ENSG00000116679 HEK293_OSMI2_6hA HEK293_TMG_6hB IVNS1ABP protein_coding   23.07795 13.23506 32.97683 2.34542 0.4984862 1.316436 1.2187560 0.0000000 3.064612 0.00000000 0.2875209 8.26426041 0.03959583 0.00000000 0.0927000 0.09270000 3.092834e-15 9.570269e-16 FALSE TRUE
MSTRG.2748.6 ENSG00000116679 HEK293_OSMI2_6hA HEK293_TMG_6hB IVNS1ABP protein_coding   23.07795 13.23506 32.97683 2.34542 0.4984862 1.316436 1.2051463 0.1525640 3.386489 0.07845565 0.5680805 4.38496487 0.03966250 0.01243333 0.1032667 0.09083333 8.511846e-03 9.570269e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116679 E001 21.1733017 0.0051010141 1.487566e-01 0.3605036789 1 185296388 185296670 283 - 1.377 1.234 -0.498
ENSG00000116679 E002 19.5157924 0.0457641319 6.114321e-01 0.7778561550 1 185296671 185296738 68 - 1.320 1.272 -0.168
ENSG00000116679 E003 39.5370670 0.0049438381 2.951360e-01 0.5356396976 1 185296739 185297014 276 - 1.626 1.537 -0.303
ENSG00000116679 E004 126.4404845 0.0009254043 3.822957e-01 0.6140723892 1 185297015 185297770 756 - 2.089 2.097 0.026
ENSG00000116679 E005 100.5051451 0.0005043868 4.097491e-05 0.0007026641 1 185297771 185297957 187 - 1.940 2.067 0.426
ENSG00000116679 E006 52.3462077 0.0083346636 1.079882e-01 0.2956978803 1 185297958 185297974 17 - 1.676 1.760 0.283
ENSG00000116679 E007 59.9408849 0.0204337712 1.001130e-01 0.2820185076 1 185297975 185297987 13 - 1.719 1.841 0.414
ENSG00000116679 E008 291.9395876 0.0002027683 1.586915e-04 0.0022033745 1 185297988 185298288 301 - 2.431 2.489 0.194
ENSG00000116679 E009 7.4716032 0.1834689533 8.124055e-01 0.9036642900 1 185298405 185299709 1305 - 0.925 0.874 -0.193
ENSG00000116679 E010 246.3433979 0.0002046787 5.234107e-02 0.1851045437 1 185299710 185299883 174 - 2.373 2.397 0.080
ENSG00000116679 E011 173.7847185 0.0005709599 1.985234e-02 0.0953634522 1 185299999 185300096 98 - 2.215 2.261 0.157
ENSG00000116679 E012 111.7632782 0.0005157977 1.243427e-02 0.0681895378 1 185300097 185300130 34 - 2.015 2.082 0.224
ENSG00000116679 E013 116.9678116 0.0003931858 6.749896e-04 0.0072243499 1 185300217 185300245 29 - 2.024 2.117 0.312
ENSG00000116679 E014 181.7435767 0.0002472146 9.650863e-02 0.2756603418 1 185300246 185300343 98 - 2.240 2.264 0.080
ENSG00000116679 E015 3.1591029 0.0071328601 3.253161e-01 0.5645658870 1 185300344 185300436 93 - 0.669 0.495 -0.787
ENSG00000116679 E016 189.9433395 0.0002680139 5.782140e-02 0.1979319254 1 185300437 185300558 122 - 2.258 2.288 0.098
ENSG00000116679 E017 0.3206185 0.0274424043 4.370813e-01   1 185300559 185300918 360 - 0.173 0.000 -9.241
ENSG00000116679 E018 200.8289356 0.0004029084 4.642729e-03 0.0327005149 1 185300972 185301196 225 - 2.271 2.323 0.175
ENSG00000116679 E019 4.9466301 0.0053361028 5.392130e-02 0.1889147856 1 185301197 185301433 237 - 0.852 0.550 -1.262
ENSG00000116679 E020 163.7198336 0.0002675955 1.229151e-01 0.3203433300 1 185301434 185301563 130 - 2.195 2.218 0.077
ENSG00000116679 E021 20.7702699 0.0378305299 2.598139e-02 0.1152585131 1 185301564 185301714 151 - 1.417 1.098 -1.122
ENSG00000116679 E022 143.2825985 0.0003343744 3.979161e-01 0.6266953880 1 185305536 185305643 108 - 2.165 2.119 -0.155
ENSG00000116679 E023 175.8118474 0.0416782284 3.086673e-05 0.0005535833 1 185305644 185306484 841 - 2.355 1.889 -1.559
ENSG00000116679 E024 66.5442722 0.0272097547 3.431273e-05 0.0006050348 1 185306485 185306625 141 - 1.932 1.497 -1.474
ENSG00000116679 E025 7.9771591 0.0344202158 5.531245e-03 0.0373789375 1 185306750 185307013 264 - 1.061 0.600 -1.820
ENSG00000116679 E026 90.8160542 0.0004514880 5.309160e-01 0.7227163339 1 185307014 185307079 66 - 1.950 1.953 0.012
ENSG00000116679 E027 84.1768573 0.0004584053 8.021012e-01 0.8975530940 1 185307080 185307139 60 - 1.928 1.897 -0.104
ENSG00000116679 E028 136.7440073 0.0002992668 7.718087e-01 0.8796996187 1 185307489 185307662 174 - 2.131 2.119 -0.038
ENSG00000116679 E029 2.3246853 0.0101825127 2.005542e-01 0.4304038210 1 185307680 185308017 338 - 0.595 0.357 -1.202
ENSG00000116679 E030 78.9414055 0.0005598419 3.754405e-01 0.6085445257 1 185308800 185308875 76 - 1.912 1.855 -0.194
ENSG00000116679 E031 97.0772676 0.0004133333 3.218278e-01 0.5612940705 1 185309003 185309172 170 - 1.997 1.939 -0.195
ENSG00000116679 E032 107.4205814 0.0014748599 1.437617e-02 0.0757823408 1 185309383 185309511 129 - 2.063 1.943 -0.402
ENSG00000116679 E033 153.3936536 0.0010378527 7.869694e-05 0.0012241962 1 185311095 185311322 228 - 2.225 2.071 -0.514
ENSG00000116679 E034 97.7337359 0.0033857420 1.882612e-01 0.4147741012 1 185316953 185318670 1718 - 2.008 1.929 -0.266