ENSG00000116604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348159 ENSG00000116604 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2D protein_coding protein_coding 9.364365 14.7029 6.948349 1.907944 0.1775078 -1.080265 2.4020949 3.93642209 2.02593388 1.16711559 0.26190586 -0.9548546 0.25766667 0.261100000 0.291233333 0.03013333 0.93195213 0.01905876 FALSE TRUE
ENST00000360595 ENSG00000116604 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2D protein_coding protein_coding 9.364365 14.7029 6.948349 1.907944 0.1775078 -1.080265 3.2573252 6.41046024 2.77076676 0.54521516 0.09016690 -1.2071940 0.33868333 0.441900000 0.399300000 -0.04260000 0.83103284 0.01905876 FALSE TRUE
ENST00000464356 ENSG00000116604 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2D protein_coding protein_coding 9.364365 14.7029 6.948349 1.907944 0.1775078 -1.080265 0.4687686 0.06028598 0.51397726 0.06028598 0.13343731 2.8981955 0.05242917 0.003933333 0.073633333 0.06970000 0.01905876 0.01905876 FALSE TRUE
MSTRG.2363.1 ENSG00000116604 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2D protein_coding   9.364365 14.7029 6.948349 1.907944 0.1775078 -1.080265 1.4929541 1.67436279 0.06456625 0.83722560 0.06456625 -4.4975364 0.15040000 0.122266667 0.008966667 -0.11330000 0.62223115 0.01905876 FALSE TRUE
MSTRG.2363.5 ENSG00000116604 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2D protein_coding   9.364365 14.7029 6.948349 1.907944 0.1775078 -1.080265 0.5933721 0.80922884 1.16589347 0.51448516 0.27964611 0.5214189 0.07325417 0.053100000 0.167666667 0.11456667 0.56938068 0.01905876 FALSE TRUE
MSTRG.2363.6 ENSG00000116604 HEK293_OSMI2_6hA HEK293_TMG_6hB MEF2D protein_coding   9.364365 14.7029 6.948349 1.907944 0.1775078 -1.080265 0.8646795 1.40993433 0.29843242 0.57228001 0.07473828 -2.2027979 0.09579167 0.088533333 0.043500000 -0.04503333 0.77694184 0.01905876 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116604 E001 0.0000000       1 156463539 156463726 188 -      
ENSG00000116604 E002 262.3839603 1.1281797265 0.469768922 0.67988055 1 156463727 156466209 2483 - 2.241 2.409 0.562
ENSG00000116604 E003 284.2528816 1.1567276824 0.465654602 0.67706244 1 156466210 156467436 1227 - 2.270 2.445 0.584
ENSG00000116604 E004 9.2606228 0.1353364186 0.767330641 0.87699849 1 156467437 156467504 68 - 0.985 0.952 -0.122
ENSG00000116604 E005 63.9617395 0.2808421693 0.214454636 0.44688487 1 156467505 156467627 123 - 1.578 1.815 0.804
ENSG00000116604 E006 50.0049456 0.2295612956 0.238038205 0.47434743 1 156467628 156467656 29 - 1.492 1.707 0.732
ENSG00000116604 E007 130.2486822 0.5097554294 0.216211044 0.44894484 1 156467993 156468299 307 - 1.846 2.127 0.946
ENSG00000116604 E008 117.5843053 0.0005078025 0.266378637 0.50588697 1 156468780 156469020 241 - 1.944 2.057 0.381
ENSG00000116604 E009 95.4279524 0.0342016944 0.682770085 0.82445366 1 156475108 156475237 130 - 1.893 1.949 0.185
ENSG00000116604 E010 1.8201430 0.1356130002 0.445199540 0.66220951 1 156476494 156476514 21 - 0.490 0.382 -0.565
ENSG00000116604 E011 2.1994331 0.5405025454 0.755465083 0.86991485 1 156476929 156477011 83 - 0.318 0.510 1.050
ENSG00000116604 E012 96.4516584 0.0360004363 0.428946927 0.65028615 1 156477012 156477202 191 - 1.925 1.944 0.064
ENSG00000116604 E013 47.6838883 0.0086437628 0.128697487 0.32975815 1 156479290 156479346 57 - 1.658 1.631 -0.090
ENSG00000116604 E014 104.4887571 0.0388091485 0.416673299 0.64118658 1 156479586 156479796 211 - 1.961 1.976 0.050
ENSG00000116604 E015 2.7993745 0.3878671468 0.024585528 0.11093602 1 156480643 156480777 135 - 0.861 0.309 -2.597
ENSG00000116604 E016 88.3595948 0.0155285546 0.024587224 0.11093895 1 156480834 156480971 138 - 1.951 1.882 -0.231
ENSG00000116604 E017 120.4018916 0.0231958765 0.013645543 0.07295451 1 156482437 156482640 204 - 2.103 2.006 -0.326
ENSG00000116604 E018 60.5162714 0.0076424697 0.003054786 0.02374355 1 156483239 156483260 22 - 1.815 1.709 -0.358
ENSG00000116604 E019 87.0987139 0.0062187850 0.009126068 0.05438626 1 156483261 156483418 158 - 1.941 1.881 -0.201
ENSG00000116604 E020 33.9047988 0.0183299781 0.067651715 0.21979245 1 156483419 156483430 12 - 1.551 1.473 -0.268
ENSG00000116604 E021 0.9289411 0.0410098785 0.158503939   1 156490512 156490599 88 - 0.001 0.340 9.466
ENSG00000116604 E022 1.9476194 0.1197879739 0.565329709 0.74692486 1 156499432 156499560 129 - 0.311 0.494 1.015
ENSG00000116604 E023 52.3907087 0.0324601067 0.377834602 0.61040931 1 156500486 156500818 333 - 1.673 1.681 0.029
ENSG00000116604 E024 1.5471926 0.0119133494 0.257627379 0.49635657 1 156500819 156500822 4 - 0.183 0.445 1.771
ENSG00000116604 E025 0.6486114 0.0192418620 1.000000000   1 156501380 156501410 31 - 0.183 0.203 0.190
ENSG00000116604 E026 1.0237200 0.0164259685 0.663296101   1 156501411 156501451 41 - 0.183 0.300 0.929