ENSG00000116539

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-9 / 9
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000368346	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding	protein_coding	9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	0.8338371	0.3434742	1.3184949	0.1789104	0.08486056	1.9101158	0.08716667	0.02410000	0.11396667	0.08986667	1.948356e-01	4.058342e-17	FALSE	TRUE
ENST00000384987	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding	miRNA	9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	0.3320807	0.0000000	0.9553664	0.0000000	0.95536644	6.5930048	0.02508333	0.00000000	0.07760000	0.07760000	8.934294e-01	4.058342e-17		FALSE
ENST00000478837	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding	retained_intron	9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	0.5097958	1.3135574	0.2531710	0.6068660	0.03563965	-2.3303482	0.05312500	0.11640000	0.02213333	-0.09426667	4.461222e-01	4.058342e-17	FALSE	TRUE
ENST00000492987	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding	nonsense_mediated_decay	9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	0.5388969	1.0077501	0.6147183	0.1850570	0.14108028	-0.7041057	0.05453750	0.08466667	0.05323333	-0.03143333	5.859366e-01	4.058342e-17	TRUE	TRUE
ENST00000677825	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding	protein_coding	9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	0.5637970	0.0000000	1.1277085	0.0000000	0.56678457	6.8299872	0.05340833	0.00000000	0.09493333	0.09493333	2.955538e-01	4.058342e-17	FALSE	TRUE
ENST00000677992	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding	protein_coding	9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	2.8343773	5.6410192	0.9210958	1.8666589	0.30103516	-2.6015095	0.30299583	0.42916667	0.08123333	-0.34793333	1.571118e-03	4.058342e-17	FALSE	TRUE
ENST00000678699	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding	nonsense_mediated_decay	9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	1.3136306	2.3618717	1.8827322	0.3651082	0.95470789	-0.3255557	0.13649167	0.19816667	0.16863333	-0.02953333	9.135927e-01	4.058342e-17	TRUE	TRUE
MSTRG.2319.1	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding		9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	0.5399722	0.4259612	0.5102626	0.2132247	0.25632744	0.2550402	0.05664167	0.02923333	0.04296667	0.01373333	9.855366e-01	4.058342e-17	FALSE	TRUE
MSTRG.2319.14	ENSG00000116539	HEK293_OSMI2_6hA	HEK293_TMG_6hB	ASH1L	protein_coding		9.65624	12.29972	11.56377	2.622159	0.3969266	-0.08893906	1.3099652	0.0000000	2.9021902	0.0000000	0.33556559	8.1859608	0.13351667	0.00000000	0.25350000	0.25350000	4.058342e-17	4.058342e-17	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 51
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_6hB
HEK293_OSMI2_6hA
log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_6hB	HEK293_OSMI2_6hA	log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB

ENSG00000116539	E001	0.1779838	0.0359173865	5.339845e-01		1	155335223	155335267	45	-	0.121	0.000	-10.929
ENSG00000116539	E002	0.8757361	0.0184293008	5.968548e-01		1	155335268	155335286	19	-	0.215	0.296	0.614
ENSG00000116539	E003	1.5429409	0.0375683272	8.509940e-02	2.548049e-01	1	155335287	155335300	14	-	0.215	0.517	1.838
ENSG00000116539	E004	419.8272621	0.0096018031	3.364741e-10	2.136114e-08	1	155335301	155337172	1872	-	2.462	2.741	0.930
ENSG00000116539	E005	249.4563405	0.0022190867	2.542415e-09	1.365898e-07	1	155337173	155337751	579	-	2.310	2.469	0.528
ENSG00000116539	E006	182.1921878	0.0002528066	1.416325e-05	2.834369e-04	1	155338089	155338390	302	-	2.219	2.306	0.291
ENSG00000116539	E007	2.2958325	0.0100667900	4.994335e-01	7.003989e-01	1	155338391	155338405	15	-	0.465	0.557	0.443
ENSG00000116539	E008	73.3929040	0.0005908611	3.118568e-02	1.308905e-01	1	155339328	155339368	41	-	1.837	1.900	0.213
ENSG00000116539	E009	121.7527618	0.0066855339	5.342606e-02	1.877141e-01	1	155341936	155342102	167	-	2.050	2.124	0.248
ENSG00000116539	E010	3.4295282	0.1189287746	1.160931e-01	3.093236e-01	1	155343041	155343313	273	-	0.464	0.757	1.300
ENSG00000116539	E011	101.4745024	0.0012322042	3.533259e-02	1.424400e-01	1	155343314	155343450	137	-	1.980	2.035	0.182
ENSG00000116539	E012	58.1905439	0.0007065582	1.443961e-01	3.539825e-01	1	155343451	155343486	36	-	1.748	1.790	0.141
ENSG00000116539	E013	0.6653672	0.2260357748	9.250409e-01		1	155343592	155343603	12	-	0.215	0.220	0.044
ENSG00000116539	E014	67.0093456	0.0006450494	5.634697e-02	1.944368e-01	1	155343604	155343655	52	-	1.801	1.858	0.190
ENSG00000116539	E015	79.6026154	0.0007667215	1.358479e-01	3.411141e-01	1	155343656	155343742	87	-	1.887	1.920	0.112
ENSG00000116539	E016	67.1395109	0.0097558267	9.698119e-02	2.764661e-01	1	155344183	155344273	91	-	1.793	1.866	0.245
ENSG00000116539	E017	2.6612357	0.2680415198	3.532168e-01	5.901700e-01	1	155344274	155344591	318	-	0.678	0.421	-1.198
ENSG00000116539	E018	2.5651692	0.0088578107	1.714688e-02	8.599163e-02	1	155345963	155346207	245	-	0.712	0.296	-2.088
ENSG00000116539	E019	0.8048655	0.0182516324	2.203632e-02		1	155346350	155346382	33	-	0.415	0.000	-13.249
ENSG00000116539	E020	68.0914914	0.0009925584	2.394052e-02	1.089169e-01	1	155346383	155346469	87	-	1.799	1.871	0.244
ENSG00000116539	E021	135.7525008	0.0003188310	1.185924e-03	1.132463e-02	1	155347656	155347901	246	-	2.100	2.172	0.241
ENSG00000116539	E022	40.6155739	0.0009543585	3.306212e-03	2.523578e-02	1	155347902	155347904	3	-	1.546	1.683	0.467
ENSG00000116539	E023	87.4417750	0.0004633798	2.433841e-03	1.990475e-02	1	155349327	155349459	133	-	1.903	1.991	0.298
ENSG00000116539	E024	48.9886273	0.0008282012	4.876072e-04	5.563112e-03	1	155349542	155349596	55	-	1.622	1.773	0.511
ENSG00000116539	E025	66.8326673	0.0009593692	1.447347e-04	2.036394e-03	1	155352706	155352858	153	-	1.760	1.902	0.478
ENSG00000116539	E026	84.1148553	0.0019134564	2.229885e-02	1.035962e-01	1	155354473	155354630	158	-	1.895	1.965	0.233
ENSG00000116539	E027	77.1098468	0.0031889880	6.274410e-01	7.888608e-01	1	155357316	155357410	95	-	1.899	1.895	-0.012
ENSG00000116539	E028	91.8811708	0.0004350794	3.789722e-02	1.493507e-01	1	155357585	155357749	165	-	2.019	1.916	-0.347
ENSG00000116539	E029	67.7233079	0.0010227610	2.579006e-02	1.146440e-01	1	155360301	155360409	109	-	1.897	1.773	-0.421
ENSG00000116539	E030	0.1723744	0.0472169171	4.453515e-01		1	155370147	155370503	357	-	0.000	0.123	10.950
ENSG00000116539	E031	70.4496805	0.0005637053	1.056752e-04	1.566795e-03	1	155370504	155370650	147	-	1.941	1.749	-0.648
ENSG00000116539	E032	94.6871715	0.0007785988	2.531738e-06	6.412338e-05	1	155370777	155370983	207	-	2.074	1.869	-0.689
ENSG00000116539	E033	65.7437983	0.0007685254	1.248360e-02	6.836731e-02	1	155378281	155378389	109	-	1.890	1.753	-0.462
ENSG00000116539	E034	42.2961817	0.0009859773	6.095329e-01	7.765977e-01	1	155378503	155378548	46	-	1.663	1.610	-0.181
ENSG00000116539	E035	47.4601478	0.0009900385	7.766116e-01	8.826807e-01	1	155380043	155380116	74	-	1.703	1.662	-0.139
ENSG00000116539	E036	0.1614157	0.0330910762	5.345760e-01		1	155380117	155380131	15	-	0.120	0.000	-10.927
ENSG00000116539	E037	49.4949952	0.0082890265	8.261604e-01	9.115607e-01	1	155395459	155395553	95	-	1.723	1.678	-0.152
ENSG00000116539	E038	55.5074353	0.0007334477	2.486798e-01	4.864449e-01	1	155415744	155415923	180	-	1.795	1.714	-0.272
ENSG00000116539	E039	146.0614746	0.0026939741	5.952694e-03	3.950693e-02	1	155438327	155439068	742	-	2.231	2.100	-0.437
ENSG00000116539	E040	0.0000000				1	155440490	155440502	13	-
ENSG00000116539	E041	1.3058530	0.0304016502	5.711445e-01		1	155440503	155440593	91	-	0.414	0.297	-0.703
ENSG00000116539	E042	42.6286307	0.0087177152	2.347259e-02	1.074512e-01	1	155459797	155459898	102	-	1.722	1.537	-0.630
ENSG00000116539	E043	1.0067919	0.0172671820	9.204178e-01		1	155462453	155462599	147	-	0.292	0.296	0.028
ENSG00000116539	E044	579.2895582	0.0184450110	3.564846e-09	1.847130e-07	1	155477886	155482449	4564	-	2.916	2.529	-1.288
ENSG00000116539	E045	0.0000000				1	155520225	155520356	132	-
ENSG00000116539	E046	66.2284967	0.0006080718	7.255568e-27	4.496943e-24	1	155521100	155521618	519	-	2.022	1.486	-1.813
ENSG00000116539	E047	10.6204759	0.1895051561	6.365555e-01	7.947173e-01	1	155562153	155562291	139	-	1.157	0.964	-0.706
ENSG00000116539	E048	5.4325017	0.0790149474	8.918202e-01	9.475244e-01	1	155562292	155562295	4	-	0.848	0.786	-0.241
ENSG00000116539	E049	9.7433099	0.0290071423	3.794485e-01	6.117712e-01	1	155562296	155562778	483	-	1.106	0.959	-0.535
ENSG00000116539	E050	2.8635423	0.0311349033	6.144381e-01	7.798459e-01	1	155562779	155563072	294	-	0.654	0.554	-0.445
ENSG00000116539	E051	0.9287192	0.0160919870	1.076457e-02		1	155563073	155564202	1130	-	0.465	0.000	-13.510

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000116539

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3