ENSG00000116497

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373475 ENSG00000116497 HEK293_OSMI2_6hA HEK293_TMG_6hB S100PBP protein_coding protein_coding 16.52186 8.944558 22.91693 0.4786233 0.4881453 1.356349 7.218637 4.002992 9.588155 0.6951321 0.2340666 1.2580789 0.43516667 0.4494667 0.41886667 -0.03060000 9.621603e-01 1.805577e-24 FALSE TRUE
ENST00000477248 ENSG00000116497 HEK293_OSMI2_6hA HEK293_TMG_6hB S100PBP protein_coding processed_transcript 16.52186 8.944558 22.91693 0.4786233 0.4881453 1.356349 1.545666 1.018609 1.567997 0.6613879 0.2755023 0.6174000 0.10945417 0.1139000 0.06823333 -0.04566667 9.944452e-01 1.805577e-24   FALSE
ENST00000531123 ENSG00000116497 HEK293_OSMI2_6hA HEK293_TMG_6hB S100PBP protein_coding processed_transcript 16.52186 8.944558 22.91693 0.4786233 0.4881453 1.356349 1.638861 1.128712 2.415203 0.1766362 0.2088311 1.0907033 0.09732083 0.1286333 0.10576667 -0.02286667 8.728444e-01 1.805577e-24 FALSE TRUE
ENST00000531256 ENSG00000116497 HEK293_OSMI2_6hA HEK293_TMG_6hB S100PBP protein_coding protein_coding 16.52186 8.944558 22.91693 0.4786233 0.4881453 1.356349 1.826602 0.000000 4.855319 0.0000000 0.1600684 8.9263907 0.08586667 0.0000000 0.21176667 0.21176667 1.805577e-24 1.805577e-24 FALSE TRUE
MSTRG.783.7 ENSG00000116497 HEK293_OSMI2_6hA HEK293_TMG_6hB S100PBP protein_coding   16.52186 8.944558 22.91693 0.4786233 0.4881453 1.356349 1.518984 1.339217 2.111295 0.5500098 0.6115967 0.6528228 0.09699583 0.1442000 0.09276667 -0.05143333 8.281199e-01 1.805577e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116497 E001 0.9500890 0.0986204089 0.3262553867   1 32816767 32816982 216 + 0.344 0.155 -1.494
ENSG00000116497 E002 0.0000000       1 32817442 32817556 115 +      
ENSG00000116497 E003 0.4576437 0.1916648163 1.0000000000   1 32817557 32817574 18 + 0.169 0.157 -0.132
ENSG00000116497 E004 0.4576437 0.1916648163 1.0000000000   1 32817575 32817591 17 + 0.169 0.157 -0.132
ENSG00000116497 E005 0.6002783 0.4195009702 0.8503982257   1 32817592 32817599 8 + 0.231 0.157 -0.682
ENSG00000116497 E006 11.5090377 0.2998381083 0.1988191533 0.428195418 1 32817600 32817652 53 + 0.973 1.229 0.926
ENSG00000116497 E007 11.8434479 0.3174958503 0.2302006748 0.465352933 1 32817653 32817654 2 + 0.993 1.230 0.854
ENSG00000116497 E008 12.4515485 0.3538607994 0.2936535556 0.534308267 1 32817655 32817655 1 + 1.032 1.230 0.713
ENSG00000116497 E009 26.5743042 0.6365510193 0.3938231935 0.623399716 1 32817656 32817689 34 + 1.358 1.522 0.566
ENSG00000116497 E010 0.1723744 0.0347614627 0.2788178417   1 32817699 32817737 39 + 0.000 0.156 11.585
ENSG00000116497 E011 2.3091763 0.0097481381 0.0001646163 0.002272631 1 32817738 32817846 109 + 0.171 0.792 3.430
ENSG00000116497 E012 2.9880609 0.0609215955 0.6517212635 0.804617403 1 32818280 32818345 66 + 0.562 0.648 0.380
ENSG00000116497 E013 8.3025270 0.1980073583 0.2140636915 0.446437243 1 32818525 32818835 311 + 0.780 1.147 1.371
ENSG00000116497 E014 3.3501856 0.1293771047 0.9577716536 0.980727266 1 32820547 32820599 53 + 0.615 0.650 0.149
ENSG00000116497 E015 4.4778105 0.0929102067 0.4382759039 0.657440215 1 32824897 32825312 416 + 0.663 0.821 0.641
ENSG00000116497 E016 76.5154217 0.0139754569 0.6927408605 0.830873163 1 32825313 32825429 117 + 1.884 1.856 -0.092
ENSG00000116497 E017 0.6081007 0.0204661363 0.1208946120   1 32825430 32825485 56 + 0.293 0.000 -13.504
ENSG00000116497 E018 214.4933219 0.0058399862 0.0022846394 0.018952876 1 32826098 32826538 441 + 2.357 2.242 -0.384
ENSG00000116497 E019 196.6225924 0.0015189721 0.1178759149 0.312357288 1 32826539 32826930 392 + 2.292 2.254 -0.129
ENSG00000116497 E020 36.4809168 0.0105877162 0.5334352094 0.724525266 1 32827993 32827995 3 + 1.569 1.529 -0.138
ENSG00000116497 E021 97.4347154 0.0026365129 0.6097088911 0.776718600 1 32827996 32828081 86 + 1.980 1.966 -0.046
ENSG00000116497 E022 104.1799989 0.0005950047 0.5652592001 0.746876652 1 32829964 32830067 104 + 1.996 2.023 0.092
ENSG00000116497 E023 3.8835581 0.0071747504 0.1742408050 0.396172128 1 32834034 32834061 28 + 0.590 0.792 0.845
ENSG00000116497 E024 7.3473670 0.1731240441 0.4738346858 0.682690341 1 32834865 32837178 2314 + 0.814 1.037 0.842
ENSG00000116497 E025 2.1054123 0.1631755755 0.3183013745 0.558202224 1 32842783 32843187 405 + 0.385 0.610 1.106
ENSG00000116497 E026 0.1723744 0.0347614627 0.2788178417   1 32846802 32846875 74 + 0.000 0.156 11.585
ENSG00000116497 E027 0.6673924 0.0189025905 0.1180576565   1 32847315 32847671 357 + 0.094 0.361 2.428
ENSG00000116497 E028 1.4280909 0.0128910000 0.0121298906 0.066970136 1 32847672 32847722 51 + 0.171 0.605 2.651
ENSG00000116497 E029 0.9764321 0.0367476959 0.5035751941   1 32852749 32852763 15 + 0.237 0.361 0.839
ENSG00000116497 E030 2.5334834 0.2732247300 0.2496145305 0.487449489 1 32852764 32852960 197 + 0.396 0.694 1.404
ENSG00000116497 E031 2.6169283 0.1565103377 0.1586073933 0.374678243 1 32852961 32853078 118 + 0.392 0.700 1.451
ENSG00000116497 E032 94.1652359 0.0006215489 0.5890727950 0.763018184 1 32853079 32853166 88 + 1.951 1.978 0.091
ENSG00000116497 E033 591.5856029 0.0066016668 0.5429472640 0.731175871 1 32855924 32858875 2952 + 2.744 2.773 0.097