ENSG00000116406

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318130 ENSG00000116406 HEK293_OSMI2_6hA HEK293_TMG_6hB EDEM3 protein_coding protein_coding 10.69874 3.240792 18.6938 0.8701135 0.6465492 2.524468 0.06857229 0.193712443 0.08269475 0.193712443 0.08269475 -1.135975 0.01546667 0.062566667 0.004700000 -0.05786667 8.517750e-01 8.003865e-08 FALSE TRUE
ENST00000439962 ENSG00000116406 HEK293_OSMI2_6hA HEK293_TMG_6hB EDEM3 protein_coding nonsense_mediated_decay 10.69874 3.240792 18.6938 0.8701135 0.6465492 2.524468 0.43621878 0.884602817 0.00000000 0.572558899 0.00000000 -6.483175 0.14182083 0.228533333 0.000000000 -0.22853333 8.003865e-08 8.003865e-08 TRUE TRUE
ENST00000466392 ENSG00000116406 HEK293_OSMI2_6hA HEK293_TMG_6hB EDEM3 protein_coding retained_intron 10.69874 3.240792 18.6938 0.8701135 0.6465492 2.524468 0.26753986 0.256547171 0.02858805 0.256547171 0.02858805 -2.788165 0.08520833 0.053266667 0.001633333 -0.05163333 7.912318e-01 8.003865e-08 FALSE TRUE
ENST00000686225 ENSG00000116406 HEK293_OSMI2_6hA HEK293_TMG_6hB EDEM3 protein_coding protein_coding 10.69874 3.240792 18.6938 0.8701135 0.6465492 2.524468 1.78555477 0.055114747 2.39095212 0.055114747 1.32231899 5.204479 0.14258333 0.030433333 0.130866667 0.10043333 7.547902e-01 8.003865e-08 FALSE TRUE
ENST00000687113 ENSG00000116406 HEK293_OSMI2_6hA HEK293_TMG_6hB EDEM3 protein_coding protein_coding 10.69874 3.240792 18.6938 0.8701135 0.6465492 2.524468 4.93869863 1.582386866 9.76091065 0.219782584 1.38689560 2.617302 0.36760000 0.546900000 0.518233333 -0.02866667 9.822264e-01 8.003865e-08 FALSE TRUE
MSTRG.2737.18 ENSG00000116406 HEK293_OSMI2_6hA HEK293_TMG_6hB EDEM3 protein_coding   10.69874 3.240792 18.6938 0.8701135 0.6465492 2.524468 1.35609228 0.009913506 2.78950242 0.009913506 0.41318183 7.135279 0.07475417 0.005466667 0.150800000 0.14533333 4.264329e-06 8.003865e-08 TRUE TRUE
MSTRG.2737.19 ENSG00000116406 HEK293_OSMI2_6hA HEK293_TMG_6hB EDEM3 protein_coding   10.69874 3.240792 18.6938 0.8701135 0.6465492 2.524468 0.40095686 0.000000000 0.90130821 0.000000000 0.90130821 6.509867 0.02144583 0.000000000 0.051300000 0.05130000 1.000000e+00 8.003865e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116406 E001 0.1779838 0.106491128 1.0000000000   1 184690237 184690492 256 - 0.048 0.000 -8.817
ENSG00000116406 E002 0.0000000       1 184690493 184690502 10 -      
ENSG00000116406 E003 0.1308682 0.031414167 0.0850644404   1 184690503 184690517 15 - 0.000 0.278 14.676
ENSG00000116406 E004 0.1308682 0.031414167 0.0850644404   1 184690518 184690518 1 - 0.000 0.278 14.676
ENSG00000116406 E005 0.5470056 0.183026023 0.1780544473   1 184690519 184690539 21 - 0.089 0.441 2.944
ENSG00000116406 E006 4.2753459 0.233383555 0.2605442093 0.499535978 1 184690540 184690570 31 - 0.509 0.939 1.789
ENSG00000116406 E007 9.7720635 0.163985753 0.0041906018 0.030215284 1 184690571 184690586 16 - 0.690 1.421 2.701
ENSG00000116406 E008 35.9249264 0.569895543 0.0751247277 0.235086163 1 184690587 184690668 82 - 1.224 1.901 2.322
ENSG00000116406 E009 55.4931556 0.728014814 0.1143933558 0.306457113 1 184690669 184690820 152 - 1.417 2.066 2.199
ENSG00000116406 E010 38.9252338 0.604975421 0.0784252427 0.241643261 1 184690821 184690851 31 - 1.256 1.936 2.327
ENSG00000116406 E011 85.5593294 0.855096294 0.1004233448 0.282545994 1 184690852 184691353 502 - 1.558 2.313 2.541
ENSG00000116406 E012 13.0926099 0.479161026 0.1873896253 0.413582018 1 184691354 184691371 18 - 0.828 1.468 2.308
ENSG00000116406 E013 81.9855401 0.897608699 0.1790525394 0.402719390 1 184691372 184691730 359 - 1.578 2.238 2.221
ENSG00000116406 E014 92.3219058 1.183296494 0.2637699269 0.503028673 1 184691731 184691983 253 - 1.656 2.239 1.960
ENSG00000116406 E015 49.3678496 0.736746107 0.2189843994 0.452234354 1 184691984 184692011 28 - 1.419 1.912 1.678
ENSG00000116406 E016 84.8120610 1.173233930 0.3452625438 0.582820800 1 184692012 184692145 134 - 1.661 2.109 1.511
ENSG00000116406 E017 166.2582184 1.440594147 0.4654321609 0.676890794 1 184692146 184692912 767 - 1.968 2.342 1.251
ENSG00000116406 E018 103.8560820 1.286558496 0.5498448340 0.736171076 1 184692913 184693365 453 - 1.789 2.057 0.900
ENSG00000116406 E019 24.2743728 0.549815235 0.4064224058 0.633343883 1 184693366 184693373 8 - 1.174 1.466 1.021
ENSG00000116406 E020 40.1875128 0.738021855 0.4828745802 0.689037791 1 184693374 184693432 59 - 1.389 1.645 0.876
ENSG00000116406 E021 132.9352894 1.409807039 0.6249866008 0.787326322 1 184693433 184694043 611 - 1.907 2.108 0.675
ENSG00000116406 E022 100.2691746 0.755712192 0.6127350972 0.778737100 1 184694044 184694472 429 - 1.794 1.947 0.512
ENSG00000116406 E023 0.0000000       1 184701497 184701529 33 -      
ENSG00000116406 E024 0.1426347 0.030951651 1.0000000000   1 184701530 184701541 12 - 0.047 0.000 -8.793
ENSG00000116406 E025 0.1426347 0.030951651 1.0000000000   1 184701542 184701544 3 - 0.047 0.000 -8.793
ENSG00000116406 E026 79.1722871 0.004340303 0.0528517463 0.186359490 1 184702811 184702996 186 - 1.707 1.805 0.331
ENSG00000116406 E027 0.4868358 0.590970334 0.5850867619   1 184702997 184703659 663 - 0.093 0.272 1.863
ENSG00000116406 E028 97.2605357 0.037865194 0.0608465057 0.204693571 1 184706643 184706808 166 - 1.799 1.827 0.092
ENSG00000116406 E029 57.3791951 0.041097550 0.0277133350 0.120456648 1 184708153 184708210 58 - 1.583 1.543 -0.134
ENSG00000116406 E030 80.8524983 0.037088684 0.0265920900 0.117045564 1 184708211 184708344 134 - 1.726 1.704 -0.074
ENSG00000116406 E031 53.4133943 0.040364946 0.0136867285 0.073103359 1 184710394 184710450 57 - 1.557 1.474 -0.283
ENSG00000116406 E032 70.6011933 0.036150526 0.0006692643 0.007175736 1 184710451 184710547 97 - 1.681 1.515 -0.567
ENSG00000116406 E033 8.8182382 0.005538028 0.0315699639 0.131974952 1 184710548 184710550 3 - 0.839 0.663 -0.712
ENSG00000116406 E034 100.3114511 0.042499372 0.0018108478 0.015772059 1 184711723 184711877 155 - 1.827 1.706 -0.407
ENSG00000116406 E035 3.4783163 0.088139575 0.6298682186 0.790369678 1 184711878 184712432 555 - 0.504 0.566 0.292
ENSG00000116406 E036 86.8263674 0.057904048 0.0074151485 0.046626592 1 184712433 184712598 166 - 1.764 1.666 -0.334
ENSG00000116406 E037 8.0541909 0.005488712 0.9691217289 0.986378104 1 184713523 184716887 3365 - 0.768 0.959 0.736
ENSG00000116406 E038 58.2981026 0.063710211 0.0549696959 0.191269899 1 184716888 184717012 125 - 1.588 1.567 -0.070
ENSG00000116406 E039 48.9242952 0.052836439 0.1222571500 0.319418481 1 184717540 184717623 84 - 1.507 1.533 0.088
ENSG00000116406 E040 0.3206185 0.025675645 1.0000000000   1 184718838 184719161 324 - 0.090 0.000 -9.795
ENSG00000116406 E041 60.3213700 0.053451824 0.1749027091 0.397028588 1 184719162 184719245 84 - 1.592 1.648 0.191
ENSG00000116406 E042 0.6246688 0.019476247 0.5282350777   1 184719246 184719442 197 - 0.165 0.000 -10.794
ENSG00000116406 E043 73.2935902 0.054028669 0.0177345512 0.088124259 1 184719443 184719568 126 - 1.689 1.620 -0.235
ENSG00000116406 E044 1.1342298 0.305893835 0.8862706570   1 184719569 184720509 941 - 0.229 0.280 0.384
ENSG00000116406 E045 0.7860845 0.017046456 0.3854480007   1 184720510 184721288 779 - 0.198 0.000 -11.116
ENSG00000116406 E046 67.7075653 0.072611302 0.0049487414 0.034358549 1 184721289 184721386 98 - 1.666 1.496 -0.580
ENSG00000116406 E047 69.1602276 0.071119492 0.0112156576 0.063254992 1 184723751 184723856 106 - 1.671 1.536 -0.462
ENSG00000116406 E048 0.0000000       1 184725055 184726254 1200 -      
ENSG00000116406 E049 72.4761109 0.078443121 0.0203909896 0.097282637 1 184726255 184726389 135 - 1.690 1.568 -0.415
ENSG00000116406 E050 0.1779838 0.106491128 1.0000000000   1 184732783 184732836 54 - 0.048 0.000 -8.800
ENSG00000116406 E051 76.4726247 0.081821898 0.0121584135 0.067103616 1 184732837 184732990 154 - 1.716 1.564 -0.514
ENSG00000116406 E052 1.1834409 0.038687577 0.7371962133   1 184732991 184734339 1349 - 0.257 0.278 0.155
ENSG00000116406 E053 56.1755354 0.056535937 0.0007474977 0.007839816 1 184734531 184734643 113 - 1.592 1.347 -0.843
ENSG00000116406 E054 0.5173834 0.293245757 0.7528307356   1 184736950 184737024 75 - 0.131 0.000 -10.407
ENSG00000116406 E055 33.9613696 0.049607746 0.0013289493 0.012376537 1 184737025 184737064 40 - 1.382 1.129 -0.888
ENSG00000116406 E056 43.5158572 0.080219785 0.0247064406 0.111318932 1 184737611 184737711 101 - 1.475 1.346 -0.446
ENSG00000116406 E057 0.0000000       1 184737712 184737736 25 -      
ENSG00000116406 E058 0.8787002 1.277837263 0.4983659575   1 184744635 184746749 2115 - 0.137 0.456 2.330
ENSG00000116406 E059 27.3608724 0.077845036 0.0151370263 0.078604875 1 184749547 184749592 46 - 1.287 1.097 -0.675
ENSG00000116406 E060 50.3709423 0.057853198 0.6192621926 0.783328119 1 184754489 184754907 419 - 1.500 1.665 0.562