ENSG00000116237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343813 ENSG00000116237 HEK293_OSMI2_6hA HEK293_TMG_6hB ICMT protein_coding protein_coding 90.31842 59.10549 97.87831 5.575364 3.01352 0.7276004 46.975320 38.4001505 46.032104 3.50486122 1.6804322 0.2614662 0.53125833 0.650166667 0.4701333 -0.18003333 1.840123e-06 3.625266e-14 FALSE TRUE
ENST00000489498 ENSG00000116237 HEK293_OSMI2_6hA HEK293_TMG_6hB ICMT protein_coding nonsense_mediated_decay 90.31842 59.10549 97.87831 5.575364 3.01352 0.7276004 14.525999 6.6971285 18.561183 0.97574234 0.7994987 1.4692986 0.15577083 0.115800000 0.1900667 0.07426667 2.866434e-01 3.625266e-14 FALSE TRUE
ENST00000495791 ENSG00000116237 HEK293_OSMI2_6hA HEK293_TMG_6hB ICMT protein_coding processed_transcript 90.31842 59.10549 97.87831 5.575364 3.01352 0.7276004 12.071191 6.6214890 14.421463 2.28977693 0.9884711 1.1218128 0.13300833 0.109233333 0.1482667 0.03903333 7.553906e-01 3.625266e-14   FALSE
MSTRG.192.6 ENSG00000116237 HEK293_OSMI2_6hA HEK293_TMG_6hB ICMT protein_coding   90.31842 59.10549 97.87831 5.575364 3.01352 0.7276004 8.327446 5.8097745 6.254893 0.47610754 1.1364961 0.1063267 0.09412917 0.098500000 0.0633000 -0.03520000 3.275040e-01 3.625266e-14 TRUE FALSE
MSTRG.192.9 ENSG00000116237 HEK293_OSMI2_6hA HEK293_TMG_6hB ICMT protein_coding   90.31842 59.10549 97.87831 5.575364 3.01352 0.7276004 4.806993 0.2116378 10.219996 0.08131366 0.7228430 5.5284580 0.04712500 0.003566667 0.1041667 0.10060000 3.625266e-14 3.625266e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116237 E001 11.0022469 0.2507413237 2.023590e-01 4.326074e-01 1 6219236 6221118 1883 - 0.912 1.203 1.060
ENSG00000116237 E002 1.3983512 0.0811187222 2.608949e-01 4.998810e-01 1 6221119 6221192 74 - 0.282 0.481 1.144
ENSG00000116237 E003 2.1075396 0.0117031045 1.102201e-03 1.068556e-02 1 6221193 6221196 4 - 0.117 0.675 3.601
ENSG00000116237 E004 57.2039556 0.2285936598 1.186029e-01 3.135839e-01 1 6221197 6221313 117 - 1.616 1.883 0.901
ENSG00000116237 E005 915.2218966 0.0005508186 4.935315e-18 1.148123e-15 1 6221314 6221897 584 - 2.895 3.017 0.407
ENSG00000116237 E006 417.6282731 0.0031541330 1.187974e-02 6.593197e-02 1 6221898 6222160 263 - 2.582 2.655 0.243
ENSG00000116237 E007 1381.8524823 0.0008822946 3.237947e-07 1.055630e-05 1 6222161 6223437 1277 - 3.101 3.175 0.245
ENSG00000116237 E008 202.7551695 0.0070579606 2.623921e-01 5.015934e-01 1 6223438 6223490 53 - 2.279 2.331 0.174
ENSG00000116237 E009 2553.4986630 0.0034182725 1.630321e-01 3.812582e-01 1 6223491 6224598 1108 - 3.421 3.390 -0.105
ENSG00000116237 E010 1623.0760916 0.0019544829 1.661485e-05 3.262160e-04 1 6224599 6225262 664 - 3.249 3.162 -0.291
ENSG00000116237 E011 815.1836986 0.0001051666 1.821081e-18 4.453152e-16 1 6231902 6232119 218 - 2.963 2.839 -0.414
ENSG00000116237 E012 515.9805909 0.0073507915 7.935675e-02 2.435325e-01 1 6233474 6233643 170 - 2.753 2.666 -0.287
ENSG00000116237 E013 42.9847815 0.0058998028 5.161329e-01 7.123504e-01 1 6234405 6234511 107 - 1.630 1.660 0.101
ENSG00000116237 E014 257.0033032 1.5850560362 6.334894e-01 7.926342e-01 1 6234886 6234970 85 - 2.387 2.436 0.161
ENSG00000116237 E015 94.2293589 1.2093542915 5.158084e-01 7.121533e-01 1 6234971 6234974 4 - 1.917 2.036 0.398
ENSG00000116237 E016 0.6673924 0.0187986456 2.582691e-01   1 6235500 6235716 217 - 0.117 0.304 1.721
ENSG00000116237 E017 136.4606873 0.1613425200 2.301742e-01 4.653219e-01 1 6235717 6236019 303 - 2.059 2.209 0.501