ENSG00000116212

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319223 ENSG00000116212 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC42 protein_coding protein_coding 26.55708 17.90634 25.0325 1.998131 0.798786 0.4831027 11.153089 8.8149146 11.161497 1.3930784 0.8093880 0.3401683 0.42827500 0.48676667 0.44593333 -0.040833333 0.849137735 0.002032004 FALSE  
ENST00000371370 ENSG00000116212 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC42 protein_coding protein_coding 26.55708 17.90634 25.0325 1.998131 0.798786 0.4831027 9.725179 6.4186409 8.432885 0.7050713 0.7593669 0.3932223 0.36725000 0.35963333 0.33673333 -0.022900000 0.927380005 0.002032004 FALSE  
MSTRG.1233.3 ENSG00000116212 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC42 protein_coding   26.55708 17.90634 25.0325 1.998131 0.798786 0.4831027 1.751743 1.4781701 1.909460 0.1828837 0.3914814 0.3671607 0.06695833 0.08380000 0.07543333 -0.008366667 0.945985278 0.002032004 FALSE  
MSTRG.1233.6 ENSG00000116212 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC42 protein_coding   26.55708 17.90634 25.0325 1.998131 0.798786 0.4831027 2.249022 0.8788319 3.276443 0.1275240 0.1382452 1.8865444 0.08287917 0.04976667 0.13150000 0.081733333 0.002032004 0.002032004 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116212 E001 1.7348021 0.0506897817 0.191615523 0.41892892 1 53946085 53946110 26 + 0.542 0.302 -1.308
ENSG00000116212 E002 3.5301115 0.0229901409 0.021028112 0.09943910 1 53946350 53946351 2 + 0.456 0.824 1.609
ENSG00000116212 E003 4.3399509 0.0549482013 0.019085533 0.09276366 1 53946352 53946352 1 + 0.499 0.901 1.692
ENSG00000116212 E004 4.9935516 0.0070932178 0.002800899 0.02219378 1 53946353 53946357 5 + 0.542 0.956 1.695
ENSG00000116212 E005 52.9828938 0.0042673142 0.032139855 0.13363579 1 53946358 53946448 91 + 1.671 1.790 0.404
ENSG00000116212 E006 76.7453916 0.0127812266 0.089668794 0.26319305 1 53946449 53946524 76 + 1.835 1.947 0.377
ENSG00000116212 E007 55.8272933 0.0132428833 0.088432862 0.26087574 1 53946525 53946549 25 + 1.695 1.814 0.403
ENSG00000116212 E008 0.1723744 0.0352433982 0.452473068   1 53946659 53946688 30 + 0.000 0.126 9.360
ENSG00000116212 E009 28.9967603 0.0114642790 0.596689086 0.76808981 1 53947788 53947821 34 + 1.460 1.502 0.142
ENSG00000116212 E010 11.6186653 0.0047305958 0.743007567 0.86235005 1 53947862 53947981 120 + 1.085 1.117 0.115
ENSG00000116212 E011 317.7470641 0.0018048412 0.208015863 0.43944218 1 53951986 53952472 487 + 2.515 2.487 -0.095
ENSG00000116212 E012 138.0433910 0.0050282025 0.638967656 0.79623705 1 53958149 53958280 132 + 2.129 2.155 0.086
ENSG00000116212 E013 151.1111174 0.0035672151 0.475335657 0.68374722 1 53960356 53960474 119 + 2.193 2.168 -0.085
ENSG00000116212 E014 1.4380223 0.6221189444 0.505811606 0.70481858 1 53961953 53962033 81 + 0.469 0.235 -1.436
ENSG00000116212 E015 136.9724790 0.0016311355 0.650420361 0.80380674 1 53962034 53962122 89 + 2.145 2.131 -0.049
ENSG00000116212 E016 2.4032354 0.0871918150 0.895868964 0.94970633 1 53962123 53962295 173 + 0.504 0.529 0.118
ENSG00000116212 E017 163.7077860 0.0003457581 0.068439650 0.22158576 1 53962296 53962409 114 + 2.241 2.193 -0.160
ENSG00000116212 E018 126.3842741 0.0046355724 0.253887362 0.49227556 1 53966296 53966380 85 + 2.129 2.085 -0.147
ENSG00000116212 E019 289.8722455 0.0036304950 0.825028847 0.91096321 1 53967665 53968168 504 + 2.464 2.460 -0.014