ENSG00000116191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367632 ENSG00000116191 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGPS2 protein_coding protein_coding 6.595585 1.333192 12.59045 0.3977113 0.3075258 3.229738 1.9108949 0.00000000 4.00569184 0.00000000 0.76936443 8.649505 0.1573750 0.0000000 0.315633333 0.31563333 1.611169e-06 4.784433e-11 FALSE FALSE
ENST00000367634 ENSG00000116191 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGPS2 protein_coding protein_coding 6.595585 1.333192 12.59045 0.3977113 0.3075258 3.229738 3.4588505 0.64178971 6.29876064 0.19163918 0.12397100 3.274878 0.5425167 0.4809333 0.501000000 0.02006667 9.647535e-01 4.784433e-11 FALSE TRUE
ENST00000367635 ENSG00000116191 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGPS2 protein_coding protein_coding 6.595585 1.333192 12.59045 0.3977113 0.3075258 3.229738 0.4846047 0.08689462 0.85887754 0.08689462 0.37755086 3.164664 0.0561250 0.0548000 0.069233333 0.01443333 8.942708e-01 4.784433e-11 FALSE TRUE
ENST00000478871 ENSG00000116191 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGPS2 protein_coding retained_intron 6.595585 1.333192 12.59045 0.3977113 0.3075258 3.229738 0.2610443 0.52703686 0.03596622 0.21148642 0.03596622 -3.546375 0.1798167 0.3784333 0.002733333 -0.37570000 4.784433e-11 4.784433e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116191 E001 0.2852693 0.350512114 1.000000e+00   1 178725165 178725218 54 + 0.094 0.000 -8.489
ENSG00000116191 E002 0.4279040 0.639918236 1.000000e+00   1 178725219 178725243 25 + 0.132 0.000 -10.399
ENSG00000116191 E003 9.9941079 0.737286474 8.811480e-01 9.419090e-01 1 178725244 178725395 152 + 0.907 0.768 -0.540
ENSG00000116191 E004 8.2674676 0.638764203 8.664063e-01 9.339994e-01 1 178725396 178725419 24 + 0.818 0.834 0.062
ENSG00000116191 E005 24.9630654 0.037600986 4.993149e-01 7.003258e-01 1 178776682 178776821 140 + 1.264 1.221 -0.150
ENSG00000116191 E006 25.5747931 0.001435724 2.737705e-01 5.136956e-01 1 178784418 178784522 105 + 1.275 1.207 -0.241
ENSG00000116191 E007 16.0938282 0.002110743 2.030901e-01 4.334531e-01 1 178785557 178785607 51 + 1.093 0.973 -0.442
ENSG00000116191 E008 22.8033527 0.001672070 2.083577e-01 4.398580e-01 1 178808045 178808128 84 + 1.227 1.133 -0.334
ENSG00000116191 E009 28.6816883 0.001447967 1.958414e-03 1.678952e-02 1 178811315 178811404 90 + 1.339 1.044 -1.048
ENSG00000116191 E010 24.0973781 0.005272621 4.640713e-03 3.269174e-02 1 178821612 178821704 93 + 1.274 0.972 -1.087
ENSG00000116191 E011 36.1926879 0.001467225 9.217867e-04 9.277579e-03 1 178833424 178833550 127 + 1.438 1.159 -0.975
ENSG00000116191 E012 41.2792422 0.003782556 1.505659e-02 7.829489e-02 1 178877498 178877635 138 + 1.483 1.307 -0.610
ENSG00000116191 E013 22.9480990 0.001909792 1.192822e-01 3.146942e-01 1 178878902 178878944 43 + 1.236 1.106 -0.465
ENSG00000116191 E014 22.4882630 0.010993444 1.797482e-02 8.894858e-02 1 178878945 178878992 48 + 1.240 0.973 -0.966
ENSG00000116191 E015 0.6600180 0.019387492 8.641534e-01   1 178878993 178879788 796 + 0.175 0.000 -12.047
ENSG00000116191 E016 22.1782957 0.023145139 2.111663e-02 9.972161e-02 1 178883466 178883533 68 + 1.233 0.935 -1.080
ENSG00000116191 E017 32.0572614 0.001491854 1.394931e-01 3.467212e-01 1 178885076 178885211 136 + 1.367 1.270 -0.338
ENSG00000116191 E018 4.7178418 0.020915123 2.571267e-01 4.958919e-01 1 178885212 178885621 410 + 0.639 0.429 -0.994
ENSG00000116191 E019 18.3803420 0.002448599 7.761440e-01 8.824557e-01 1 178885969 178885976 8 + 1.115 1.184 0.247
ENSG00000116191 E020 33.2133197 0.001293724 8.375012e-01 9.180494e-01 1 178885977 178886078 102 + 1.368 1.389 0.076
ENSG00000116191 E021 19.3598518 0.002078467 1.003573e-01 2.824444e-01 1 178886079 178886120 42 + 1.169 1.010 -0.574
ENSG00000116191 E022 22.4590086 0.001726894 3.755117e-01 6.086019e-01 1 178889642 178889696 55 + 1.214 1.159 -0.195
ENSG00000116191 E023 2.7530708 0.060396069 7.962474e-01 8.941244e-01 1 178892230 178892307 78 + 0.456 0.543 0.424
ENSG00000116191 E024 0.1779838 0.048320548 9.417063e-01   1 178893838 178893918 81 + 0.051 0.000 -9.841
ENSG00000116191 E025 32.9180377 0.001420092 7.743315e-01 8.813567e-01 1 178893919 178894024 106 + 1.354 1.418 0.224
ENSG00000116191 E026 0.6600180 0.019387492 8.641534e-01   1 178894025 178894325 301 + 0.175 0.000 -12.047
ENSG00000116191 E027 40.3601638 0.008161435 4.366180e-01 6.561912e-01 1 178897664 178897756 93 + 1.451 1.419 -0.111
ENSG00000116191 E028 50.4789354 0.001415181 6.017690e-01 7.713179e-01 1 178902106 178902211 106 + 1.545 1.549 0.013
ENSG00000116191 E029 39.4659574 0.002956952 9.281853e-01 9.661037e-01 1 178906776 178906867 92 + 1.436 1.483 0.161
ENSG00000116191 E030 543.0403769 0.002808983 2.622254e-10 1.700990e-08 1 178916330 178921842 5513 + 2.540 2.704 0.544