ENSG00000116161

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367679 ENSG00000116161 HEK293_OSMI2_6hA HEK293_TMG_6hB CACYBP protein_coding protein_coding 120.4834 65.17072 168.3781 12.7283 8.423119 1.369273 29.55805 21.1944287 17.06968 4.7157027 3.934643 -0.3120846 0.2616750 0.320466667 0.1028000 -0.2176667 0.0048666691 4.385484e-12 FALSE TRUE
ENST00000473925 ENSG00000116161 HEK293_OSMI2_6hA HEK293_TMG_6hB CACYBP protein_coding retained_intron 120.4834 65.17072 168.3781 12.7283 8.423119 1.369273 76.88959 41.5605040 107.52644 7.7946600 5.299944 1.3711935 0.6309083 0.640233333 0.6386333 -0.0016000 1.0000000000 4.385484e-12 FALSE TRUE
MSTRG.2635.5 ENSG00000116161 HEK293_OSMI2_6hA HEK293_TMG_6hB CACYBP protein_coding   120.4834 65.17072 168.3781 12.7283 8.423119 1.369273 6.50962 0.1598597 30.46223 0.1598597 5.573111 7.4870078 0.0504875 0.001933333 0.1794000 0.1774667 0.0002639987 4.385484e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116161 E001 2.307554 0.1790037064 3.867698e-01 6.179373e-01 1 174999163 174999434 272 + 0.581 0.362 -1.111
ENSG00000116161 E002 6.430159 0.4503283903 8.149002e-01 9.051867e-01 1 174999435 174999470 36 + 0.921 0.720 -0.790
ENSG00000116161 E003 30.688120 0.8387380770 9.126884e-01 9.584425e-01 1 174999471 174999642 172 + 1.573 1.254 -1.104
ENSG00000116161 E004 33.042539 0.0643740400 1.084416e-01 2.964616e-01 1 174999643 174999689 47 + 1.593 1.336 -0.885
ENSG00000116161 E005 1.279010 0.1509342140 4.308293e-01   1 174999945 174999946 2 + 0.289 0.491 1.149
ENSG00000116161 E006 2.058677 0.0287304530 1.235696e-01 3.213919e-01 1 174999947 174999954 8 + 0.384 0.650 1.285
ENSG00000116161 E007 188.347013 0.0003784548 1.208415e-09 6.961216e-08 1 174999955 175000088 134 + 2.199 2.361 0.539
ENSG00000116161 E008 376.001385 0.0001590723 4.234630e-08 1.717139e-06 1 175000089 175000152 64 + 2.523 2.624 0.337
ENSG00000116161 E009 472.532078 0.0001895930 1.222104e-03 1.159708e-02 1 175000153 175000180 28 + 2.641 2.694 0.176
ENSG00000116161 E010 435.433811 0.0003253021 1.086238e-01 2.967923e-01 1 175000181 175000195 15 + 2.615 2.642 0.089
ENSG00000116161 E011 12.448555 0.0048370273 5.934596e-02 2.013366e-01 1 175000213 175000599 387 + 1.041 1.223 0.654
ENSG00000116161 E012 1195.051574 0.0000754933 3.505119e-02 1.417160e-01 1 175004614 175004814 201 + 3.071 3.046 -0.082
ENSG00000116161 E013 487.246279 0.0005092721 6.784176e-02 2.202494e-01 1 175004815 175004833 19 + 2.685 2.647 -0.127
ENSG00000116161 E014 3.597463 0.2756440140 5.823884e-01 7.586445e-01 1 175004834 175005050 217 + 0.686 0.563 -0.537
ENSG00000116161 E015 3.880936 0.0307008789 6.402200e-01 7.970331e-01 1 175006583 175006744 162 + 0.701 0.611 -0.381
ENSG00000116161 E016 805.504179 0.0002242621 3.166344e-02 1.322246e-01 1 175006745 175006841 97 + 2.902 2.869 -0.110
ENSG00000116161 E017 3.784132 0.0068261048 5.555246e-01 7.401315e-01 1 175006842 175007097 256 + 0.702 0.609 -0.397
ENSG00000116161 E018 859.115057 0.0001612680 4.078713e-02 1.567564e-01 1 175007098 175007197 100 + 2.929 2.899 -0.100
ENSG00000116161 E019 1120.628138 0.0001067254 8.322060e-01 9.151157e-01 1 175008609 175008706 98 + 3.034 3.033 -0.002
ENSG00000116161 E020 9.884648 0.0582572598 1.382091e-01 3.448094e-01 1 175008707 175008897 191 + 1.104 0.849 -0.950
ENSG00000116161 E021 1755.213712 0.0001271195 6.379169e-01 7.956766e-01 1 175009923 175012027 2105 + 3.231 3.224 -0.023