ENSG00000116151

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378529 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding protein_coding 11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 1.88184196 2.76229292 1.0088851 0.40726572 0.17431891 -1.4440883 0.17432500 0.168700000 0.19600000 0.027300000 8.962412e-01 3.184084e-05 FALSE  
ENST00000469374 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding retained_intron 11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 0.51460312 0.63935872 0.4690706 0.06103078 0.09069157 -0.4387772 0.05210833 0.040400000 0.09200000 0.051600000 2.210207e-01 3.184084e-05    
ENST00000475812 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding retained_intron 11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 0.75812999 1.42014438 0.0000000 0.43279143 0.00000000 -7.1600170 0.06256667 0.085566667 0.00000000 -0.085566667 3.184084e-05 3.184084e-05 FALSE  
ENST00000494279 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding protein_coding 11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 1.68586074 2.71045523 0.1981590 0.25235522 0.19815897 -3.7080905 0.13098750 0.168066667 0.03640000 -0.131666667 2.333624e-01 3.184084e-05    
ENST00000607031 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding retained_intron 11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 0.76401603 1.08337682 0.4280037 0.15518232 0.03836334 -1.3197758 0.06899167 0.066300000 0.08340000 0.017100000 8.114537e-01 3.184084e-05 FALSE  
MSTRG.138.11 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding   11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 0.74098969 1.42974494 0.5380575 0.53471370 0.38753319 -1.3934141 0.07073333 0.089433333 0.10513333 0.015700000 9.469760e-01 3.184084e-05 FALSE  
MSTRG.138.12 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding   11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 1.05835512 0.80985180 0.3072049 0.80985180 0.25119555 -1.3699481 0.09474167 0.043233333 0.05726667 0.014033333 7.597583e-01 3.184084e-05 FALSE  
MSTRG.138.15 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding   11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 0.83515046 0.65681928 0.1443184 0.38903090 0.14431840 -2.1113858 0.07572500 0.036233333 0.02956667 -0.006666667 8.571606e-01 3.184084e-05 TRUE  
MSTRG.138.3 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding   11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 0.09770586 0.08443862 0.2973065 0.04392523 0.23423465 1.7022291 0.01242500 0.005633333 0.05996667 0.054333333 7.023176e-01 3.184084e-05 TRUE  
MSTRG.138.6 ENSG00000116151 HEK293_OSMI2_6hA HEK293_TMG_6hB MORN1 protein_coding   11.02455 16.22677 5.121754 1.687614 0.1666166 -1.661741 1.45596565 1.65961727 1.3020600 0.53637163 0.12148420 -0.3476837 0.14410833 0.098600000 0.25626667 0.157666667 5.394784e-02 3.184084e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116151 E001 3.5605162 0.007234037 0.709751691 0.84165625 1 2321253 2321579 327 - 0.533 0.613 0.363
ENSG00000116151 E002 0.3032425 0.024441170 1.000000000   1 2324038 2324079 42 - 0.000 0.129 9.416
ENSG00000116151 E003 0.6064850 0.019716023 0.372773505   1 2324080 2324096 17 - 0.000 0.228 10.361
ENSG00000116151 E004 1.7716719 0.026749708 0.808443253 0.90125223 1 2324097 2324143 47 - 0.344 0.406 0.356
ENSG00000116151 E005 4.1960759 0.006373976 0.396055106 0.62522076 1 2332126 2332753 628 - 0.533 0.695 0.714
ENSG00000116151 E006 1.9697244 0.012544565 0.189574141 0.41639780 1 2334903 2334937 35 - 0.205 0.486 1.772
ENSG00000116151 E007 5.4371228 0.006261641 0.054504054 0.19024899 1 2336469 2336545 77 - 0.449 0.802 1.558
ENSG00000116151 E008 2.9448535 0.008201127 0.260057092 0.49904494 1 2336546 2336548 3 - 0.344 0.575 1.191
ENSG00000116151 E009 7.5239913 0.076886455 0.427033327 0.64875530 1 2336717 2336850 134 - 0.722 0.892 0.671
ENSG00000116151 E010 6.4455981 0.005271270 0.092823400 0.26897499 1 2349805 2349870 66 - 0.947 0.739 -0.807
ENSG00000116151 E011 15.4874637 0.002274491 0.865520313 0.93343874 1 2355175 2355464 290 - 1.116 1.154 0.135
ENSG00000116151 E012 24.9537592 0.001692157 0.707280687 0.84010382 1 2357432 2357598 167 - 1.295 1.346 0.180
ENSG00000116151 E013 0.7392585 0.122983489 0.894843695   1 2358588 2358591 4 - 0.205 0.184 -0.195
ENSG00000116151 E014 16.1345248 0.002282515 0.527730323 0.72042163 1 2358592 2358637 46 - 1.096 1.180 0.301
ENSG00000116151 E015 18.9400290 0.010396560 0.096938666 0.27634948 1 2358638 2358715 78 - 1.333 1.199 -0.472
ENSG00000116151 E016 11.5285770 0.023192279 0.010832441 0.06165905 1 2371165 2371675 511 - 1.224 0.929 -1.072
ENSG00000116151 E017 1.2682207 0.331504651 0.102800331   1 2371676 2371681 6 - 0.537 0.190 -2.154
ENSG00000116151 E018 5.9575973 0.121997962 0.178257612 0.40155674 1 2371682 2371905 224 - 0.943 0.697 -0.966
ENSG00000116151 E019 10.4872934 0.013235496 0.025989358 0.11528251 1 2371906 2372480 575 - 1.156 0.909 -0.907
ENSG00000116151 E020 33.9470354 0.014430084 0.154573689 0.36884473 1 2372481 2372591 111 - 1.542 1.449 -0.319
ENSG00000116151 E021 30.7023336 0.020519289 0.100743588 0.28313400 1 2374461 2374557 97 - 1.525 1.400 -0.430
ENSG00000116151 E022 26.7466175 0.078118310 0.048307793 0.17573366 1 2374853 2375598 746 - 1.108 1.416 1.083
ENSG00000116151 E023 79.7332280 0.593745682 0.437010074 0.65646798 1 2375599 2377602 2004 - 1.725 1.850 0.421
ENSG00000116151 E024 32.1272936 0.240878443 0.332101452 0.57096758 1 2377603 2378054 452 - 1.315 1.470 0.539
ENSG00000116151 E025 29.5276407 0.210588901 0.201338039 0.43137899 1 2378055 2378606 552 - 1.219 1.447 0.795
ENSG00000116151 E026 24.4987780 0.185796054 0.328811370 0.56779433 1 2378607 2378980 374 - 1.176 1.365 0.662
ENSG00000116151 E027 17.5125359 0.006238990 0.297906511 0.53836651 1 2378981 2379108 128 - 1.095 1.222 0.452
ENSG00000116151 E028 21.5691677 0.062903293 0.320838157 0.56044867 1 2379109 2379227 119 - 1.167 1.303 0.480
ENSG00000116151 E029 62.2612038 0.003720779 0.656989820 0.80796569 1 2384978 2385065 88 - 1.728 1.724 -0.015
ENSG00000116151 E030 0.3088520 0.027219066 0.340734939   1 2385066 2385158 93 - 0.205 0.069 -1.812
ENSG00000116151 E031 9.8515150 0.011467463 0.225098605 0.45952446 1 2385372 2385806 435 - 0.809 0.997 0.717
ENSG00000116151 E032 85.7330500 0.002602165 0.843601858 0.92139773 1 2385807 2385897 91 - 1.836 1.867 0.105
ENSG00000116151 E033 41.8132429 0.017604982 0.433585484 0.65395563 1 2385898 2387055 1158 - 1.587 1.539 -0.161
ENSG00000116151 E034 18.5178107 0.033032721 0.128026984 0.32866123 1 2387056 2387418 363 - 1.027 1.250 0.800
ENSG00000116151 E035 92.7900208 0.004807330 0.978000913 0.99076739 1 2387419 2387529 111 - 1.874 1.896 0.075
ENSG00000116151 E036 0.1308682 0.032649190 1.000000000   1 2387530 2388003 474 - 0.000 0.069 8.428
ENSG00000116151 E037 13.9844319 0.007637682 0.024778446 0.11154296 1 2388004 2388238 235 - 0.847 1.145 1.105
ENSG00000116151 E038 89.1330340 0.004610819 0.455103889 0.66958003 1 2388239 2388337 99 - 1.888 1.870 -0.059
ENSG00000116151 E039 7.1929798 0.079888486 0.677561561 0.82119188 1 2388338 2388509 172 - 0.880 0.830 -0.194
ENSG00000116151 E040 37.0381152 0.002889339 0.182681202 0.40752791 1 2389925 2389996 72 - 1.557 1.488 -0.237
ENSG00000116151 E041 41.9087432 0.011692778 0.004831123 0.03369900 1 2391458 2391707 250 - 1.695 1.504 -0.649