ENSG00000116127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000484298 ENSG00000116127 HEK293_OSMI2_6hA HEK293_TMG_6hB ALMS1 protein_coding protein_coding 5.758063 4.477523 6.773417 0.8117513 0.2017017 0.5960929 1.1397987 0.2786907 2.37003299 0.15903681 0.58609315 3.0433851 0.18057917 0.07166667 0.350000000 0.27833333 2.770985e-01 9.226603e-05 FALSE TRUE
ENST00000620466 ENSG00000116127 HEK293_OSMI2_6hA HEK293_TMG_6hB ALMS1 protein_coding retained_intron 5.758063 4.477523 6.773417 0.8117513 0.2017017 0.5960929 0.3495074 0.1030534 0.63590301 0.07722467 0.10088217 2.5143127 0.05746250 0.03193333 0.094600000 0.06266667 4.136724e-01 9.226603e-05 FALSE TRUE
ENST00000651057 ENSG00000116127 HEK293_OSMI2_6hA HEK293_TMG_6hB ALMS1 protein_coding protein_coding 5.758063 4.477523 6.773417 0.8117513 0.2017017 0.5960929 1.5352445 1.7985731 0.64731913 0.64303322 0.33886122 -1.4601861 0.28772500 0.37730000 0.097466667 -0.27983333 4.254607e-01 9.226603e-05 FALSE TRUE
ENST00000682859 ENSG00000116127 HEK293_OSMI2_6hA HEK293_TMG_6hB ALMS1 protein_coding protein_coding 5.758063 4.477523 6.773417 0.8117513 0.2017017 0.5960929 0.3090219 0.0000000 1.00232497 0.00000000 0.54288780 6.6615287 0.04555833 0.00000000 0.147000000 0.14700000 3.710006e-01 9.226603e-05 FALSE TRUE
ENST00000683147 ENSG00000116127 HEK293_OSMI2_6hA HEK293_TMG_6hB ALMS1 protein_coding retained_intron 5.758063 4.477523 6.773417 0.8117513 0.2017017 0.5960929 0.3495237 0.2487799 0.47879584 0.01935791 0.05198610 0.9175066 0.06147500 0.06150000 0.071200000 0.00970000 9.253194e-01 9.226603e-05   FALSE
ENST00000684460 ENSG00000116127 HEK293_OSMI2_6hA HEK293_TMG_6hB ALMS1 protein_coding protein_coding 5.758063 4.477523 6.773417 0.8117513 0.2017017 0.5960929 0.2918605 0.3485308 0.27034061 0.07866771 0.06066137 -0.3549161 0.05239167 0.07633333 0.039433333 -0.03690000 3.977997e-01 9.226603e-05 FALSE TRUE
ENST00000684590 ENSG00000116127 HEK293_OSMI2_6hA HEK293_TMG_6hB ALMS1 protein_coding protein_coding 5.758063 4.477523 6.773417 0.8117513 0.2017017 0.5960929 0.2519736 0.7115135 0.06501262 0.21800658 0.03273600 -3.2658212 0.05260833 0.15043333 0.009833333 -0.14060000 9.226603e-05 9.226603e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000116127 E001 0.3559677 0.5849513505 5.708463e-01   2 73385758 73385835 78 + 0.176 0.000 -9.275
ENSG00000116127 E002 0.3559677 0.5849513505 5.708463e-01   2 73385836 73385868 33 + 0.176 0.000 -11.754
ENSG00000116127 E003 0.3559677 0.5849513505 5.708463e-01   2 73385869 73385903 35 + 0.176 0.000 -11.754
ENSG00000116127 E004 0.0000000       2 73385904 73385908 5 +      
ENSG00000116127 E005 0.9994175 0.0206059601 4.317951e-02   2 73385909 73385996 88 + 0.390 0.000 -14.012
ENSG00000116127 E006 0.8214337 0.0172671820 7.188400e-02   2 73385997 73385997 1 + 0.345 0.000 -13.769
ENSG00000116127 E007 8.2325010 0.0060087874 4.840837e-04 5.530715e-03 2 73385998 73386192 195 + 1.076 0.603 -1.859
ENSG00000116127 E008 0.1779838 0.0384111508 8.488107e-01   2 73408622 73408747 126 + 0.094 0.000 -11.515
ENSG00000116127 E009 18.6731455 0.0236405842 3.226122e-04 3.960151e-03 2 73419123 73419318 196 + 1.392 0.963 -1.532
ENSG00000116127 E010 1.1009059 0.0150163474 6.909820e-01   2 73419319 73422701 3383 + 0.345 0.269 -0.495
ENSG00000116127 E011 15.8484477 0.0182625785 2.328048e-05 4.348395e-04 2 73422857 73422974 118 + 1.335 0.819 -1.883
ENSG00000116127 E012 34.8905290 0.0012873247 2.475322e-12 2.383030e-10 2 73424430 73424902 473 + 1.668 1.156 -1.776
ENSG00000116127 E013 0.0000000       2 73424903 73424973 71 +      
ENSG00000116127 E014 14.5223579 0.0025021728 2.375162e-05 4.421806e-04 2 73426453 73426553 101 + 1.294 0.846 -1.634
ENSG00000116127 E015 0.6622309 0.1776067853 1.650572e-01   2 73432129 73432197 69 + 0.296 0.000 -13.225
ENSG00000116127 E016 12.0229425 0.0179729740 1.446488e-03 1.323600e-02 2 73432198 73432291 94 + 1.205 0.791 -1.538
ENSG00000116127 E017 0.0000000       2 73432513 73432685 173 +      
ENSG00000116127 E018 16.4675400 0.0025657423 3.809275e-06 9.105658e-05 2 73447960 73448090 131 + 1.344 0.872 -1.710
ENSG00000116127 E019 79.5807705 0.0141530784 8.228934e-10 4.882817e-08 2 73448091 73449456 1366 + 2.011 1.547 -1.570
ENSG00000116127 E020 52.9301127 0.0009680500 5.269317e-14 6.915389e-12 2 73449457 73450280 824 + 1.836 1.399 -1.491
ENSG00000116127 E021 22.6337542 0.0765061875 2.841722e-01 5.246795e-01 2 73450281 73450565 285 + 1.427 1.215 -0.739
ENSG00000116127 E022 53.4094447 0.0697258144 3.814292e-01 6.134223e-01 2 73450566 73451558 993 + 1.775 1.610 -0.562
ENSG00000116127 E023 15.3406304 0.0026463018 6.907380e-03 4.421697e-02 2 73451559 73451696 138 + 1.283 1.019 -0.945
ENSG00000116127 E024 58.0802751 0.0008472339 7.262275e-10 4.339554e-08 2 73451697 73452410 714 + 1.851 1.521 -1.121
ENSG00000116127 E025 36.6507077 0.0094731397 2.586849e-10 1.680828e-08 2 73452411 73452724 314 + 1.691 1.142 -1.903
ENSG00000116127 E026 49.6070938 0.0070404679 1.148929e-04 1.677394e-03 2 73452725 73453306 582 + 1.768 1.503 -0.899
ENSG00000116127 E027 69.4262806 0.0005927980 1.871524e-02 9.144543e-02 2 73453307 73454067 761 + 1.872 1.761 -0.373
ENSG00000116127 E028 17.4095013 0.0408950266 3.008082e-01 5.412688e-01 2 73455162 73455212 51 + 1.304 1.145 -0.563
ENSG00000116127 E029 20.7852297 0.0584675365 7.694832e-01 8.783108e-01 2 73455213 73455295 83 + 1.350 1.275 -0.263
ENSG00000116127 E030 1.6562112 0.0116755838 7.835869e-01 8.867267e-01 2 73455296 73455910 615 + 0.390 0.435 0.242
ENSG00000116127 E031 40.4478124 0.8000761306 5.748778e-01 7.535891e-01 2 73489634 73490158 525 + 1.597 1.611 0.049
ENSG00000116127 E032 58.5813784 0.5401973057 4.972555e-01 6.990910e-01 2 73490159 73490862 704 + 1.729 1.808 0.266
ENSG00000116127 E033 67.1705301 0.0361180592 6.982339e-01 8.344264e-01 2 73490863 73491498 636 + 1.809 1.838 0.097
ENSG00000116127 E034 37.4882034 0.0010102375 2.040565e-01 4.347010e-01 2 73519775 73519955 181 + 1.543 1.612 0.236
ENSG00000116127 E035 23.6378320 0.0051108121 5.326162e-01 7.239456e-01 2 73519956 73520016 61 + 1.354 1.399 0.156
ENSG00000116127 E036 33.0365430 0.0096809254 4.470124e-02 1.668747e-01 2 73534824 73534949 126 + 1.447 1.597 0.515
ENSG00000116127 E037 32.7341083 0.0098578236 1.021748e-01 2.856565e-01 2 73550267 73550437 171 + 1.454 1.578 0.424
ENSG00000116127 E038 29.0974674 0.0028671693 1.050687e-01 2.907504e-01 2 73557220 73557354 135 + 1.415 1.522 0.368
ENSG00000116127 E039 34.6500353 0.0012664598 3.469620e-01 5.845116e-01 2 73558972 73559142 171 + 1.512 1.564 0.179
ENSG00000116127 E040 22.4474878 0.0045214458 7.657518e-01 8.761143e-01 2 73572262 73572310 49 + 1.366 1.335 -0.108
ENSG00000116127 E041 45.6622816 0.0059494317 4.791036e-01 6.865044e-01 2 73572311 73572489 179 + 1.671 1.618 -0.179
ENSG00000116127 E042 128.5991549 0.0004611586 1.079121e-04 1.593007e-03 2 73572490 73573309 820 + 2.046 2.164 0.394
ENSG00000116127 E043 49.8126573 0.0027791595 5.496827e-07 1.683476e-05 2 73573310 73573424 115 + 1.564 1.834 0.917
ENSG00000116127 E044 1.3804955 0.0136384167 9.188779e-01   2 73573425 73573580 156 + 0.345 0.360 0.092
ENSG00000116127 E045 1.2333667 0.0889621330 4.423534e-01   2 73593749 73593887 139 + 0.294 0.432 0.817
ENSG00000116127 E046 0.0000000       2 73599244 73599367 124 +      
ENSG00000116127 E047 32.9599260 0.0011866500 4.677296e-07 1.461208e-05 2 73599401 73599450 50 + 1.372 1.676 1.042
ENSG00000116127 E048 41.4723900 0.0035312940 7.512117e-07 2.214919e-05 2 73599451 73599521 71 + 1.472 1.766 1.004
ENSG00000116127 E049 57.4360569 0.0189233826 1.461999e-02 7.666356e-02 2 73600678 73600834 157 + 1.662 1.863 0.678
ENSG00000116127 E050 34.0668053 0.0236754497 2.000533e-01 4.297587e-01 2 73600835 73600881 47 + 1.478 1.602 0.424
ENSG00000116127 E051 60.8613342 0.0206586288 1.927537e-02 9.342432e-02 2 73601195 73601436 242 + 1.687 1.894 0.698
ENSG00000116127 E052 50.6627477 0.0183947357 7.040827e-03 4.482453e-02 2 73602185 73602368 184 + 1.598 1.828 0.777
ENSG00000116127 E053 30.6903398 0.0020708858 1.808337e-04 2.458351e-03 2 73603241 73603298 58 + 1.385 1.621 0.811
ENSG00000116127 E054 24.3788199 0.0014148621 6.338267e-07 1.910175e-05 2 73603299 73603304 6 + 1.224 1.569 1.196
ENSG00000116127 E055 5.6881989 0.2212364620 9.436259e-02 2.718502e-01 2 73603305 73603859 555 + 0.922 0.500 -1.769
ENSG00000116127 E056 1.0103762 0.0536581894 3.203720e-01   2 73603931 73603991 61 + 0.346 0.155 -1.500
ENSG00000116127 E057 2.9142946 0.0131691817 4.918171e-01 6.952063e-01 2 73605034 73605135 102 + 0.618 0.498 -0.549
ENSG00000116127 E058 3.2502975 0.0076710717 6.000532e-01 7.702481e-01 2 73605136 73605213 78 + 0.643 0.554 -0.395
ENSG00000116127 E059 28.1992836 0.0610775658 6.432953e-01 7.990305e-01 2 73605214 73608370 3157 + 1.428 1.481 0.184
ENSG00000116127 E060 3.9121301 0.0110293969 7.745834e-02 2.397909e-01 2 73608371 73608474 104 + 0.564 0.818 1.065
ENSG00000116127 E061 36.7868130 0.0009472415 1.024028e-09 5.969910e-08 2 73608475 73608574 100 + 1.398 1.745 1.186
ENSG00000116127 E062 15.8693741 0.0020640974 2.309688e-04 3.012350e-03 2 73609568 73609569 2 + 1.067 1.376 1.095
ENSG00000116127 E063 26.3412589 0.0016071625 1.525267e-06 4.106952e-05 2 73609570 73609682 113 + 1.271 1.594 1.113
ENSG00000116127 E064 12.1445938 0.0110473394 4.372774e-03 3.122126e-02 2 73609683 73609916 234 + 0.965 1.261 1.067
ENSG00000116127 E065 1.1376601 0.0152454250 2.600948e-01   2 73610437 73610793 357 + 0.237 0.434 1.238
ENSG00000116127 E066 0.7392585 0.0414496964 1.184864e-01   2 73615267 73615380 114 + 0.094 0.361 2.420
ENSG00000116127 E067 1.2740651 0.4201834360 1.305245e-01   2 73624677 73625166 490 + 0.172 0.551 2.391