ENSG00000115977

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000606389 ENSG00000115977 HEK293_OSMI2_6hA HEK293_TMG_6hB AAK1 protein_coding protein_coding 2.682943 2.98165 3.245303 0.5839303 0.1580558 0.1218503 1.4811107 1.81630686 1.9783780 0.2311105 0.06507192 0.1226629 0.56564583 0.63473333 0.61126667 -0.02346667 0.9744258991 0.0005246902 FALSE TRUE
ENST00000623317 ENSG00000115977 HEK293_OSMI2_6hA HEK293_TMG_6hB AAK1 protein_coding protein_coding 2.682943 2.98165 3.245303 0.5839303 0.1580558 0.1218503 0.2904396 0.09429756 0.8458446 0.0533455 0.22163962 3.0366434 0.09820417 0.04293333 0.25706667 0.21413333 0.1643192205 0.0005246902 FALSE FALSE
MSTRG.18579.1 ENSG00000115977 HEK293_OSMI2_6hA HEK293_TMG_6hB AAK1 protein_coding   2.682943 2.98165 3.245303 0.5839303 0.1580558 0.1218503 0.5397277 0.77126378 0.0000000 0.3209333 0.00000000 -6.2877378 0.19950000 0.22813333 0.00000000 -0.22813333 0.0005246902 0.0005246902 FALSE TRUE
MSTRG.18579.7 ENSG00000115977 HEK293_OSMI2_6hA HEK293_TMG_6hB AAK1 protein_coding   2.682943 2.98165 3.245303 0.5839303 0.1580558 0.1218503 0.1434467 0.08219710 0.1408967 0.0432208 0.07084491 0.7107676 0.05213750 0.02740000 0.04263333 0.01523333 0.9438348257 0.0005246902 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115977 E001 336.1955230 1.273784521 2.330364e-01 4.686531e-01 2 69457997 69461399 3403 -      
ENSG00000115977 E002 22.5068691 0.150411823 4.381029e-01 6.572956e-01 2 69461400 69461705 306 -      
ENSG00000115977 E003 14.7970887 0.068633591 3.021648e-01 5.428042e-01 2 69461706 69461940 235 -      
ENSG00000115977 E004 7.9288768 0.075711858 1.157299e-01 3.087227e-01 2 69461941 69461983 43 -      
ENSG00000115977 E005 67.8979113 0.424240952 2.231961e-01 4.571959e-01 2 69461984 69464110 2127 -      
ENSG00000115977 E006 74.4517399 0.587196525 5.639204e-01 7.460553e-01 2 69464111 69465845 1735 -      
ENSG00000115977 E007 10.3532664 0.007524537 2.093741e-01 4.411371e-01 2 69465846 69466002 157 -      
ENSG00000115977 E008 16.4901725 0.196858852 8.707279e-01 9.363815e-01 2 69466003 69466352 350 -      
ENSG00000115977 E009 15.9437510 0.222345647 7.253590e-01 8.513732e-01 2 69466353 69466551 199 -      
ENSG00000115977 E010 8.6925524 0.046670705 9.695219e-01 9.866063e-01 2 69466552 69475963 9412 -      
ENSG00000115977 E011 2.0739573 0.371664400 2.585708e-01 4.973922e-01 2 69476880 69476990 111 -      
ENSG00000115977 E012 0.1614157 0.032563609 3.040462e-01   2 69478456 69478950 495 -      
ENSG00000115977 E013 1.8842070 0.391248414 5.010431e-01 7.015202e-01 2 69478951 69479061 111 -      
ENSG00000115977 E014 1.7892356 0.407299144 6.307366e-01 7.908622e-01 2 69480860 69480961 102 -      
ENSG00000115977 E015 0.3641499 0.028540787 7.304887e-01   2 69481056 69482710 1655 -      
ENSG00000115977 E016 0.3228314 0.235481795 1.418844e-01   2 69482711 69482812 102 -      
ENSG00000115977 E017 1.1417919 0.343989169 4.047301e-01   2 69495985 69496080 96 -      
ENSG00000115977 E018 0.4458772 0.021768165 9.237330e-01   2 69499869 69500301 433 -      
ENSG00000115977 E019 12.7003841 0.041265578 3.706702e-03 2.751209e-02 2 69505569 69505673 105 -      
ENSG00000115977 E020 14.4338966 0.036143922 1.096113e-03 1.064478e-02 2 69507421 69507578 158 -      
ENSG00000115977 E021 6.7022137 0.017660511 5.901390e-02 2.005547e-01 2 69509231 69509250 20 -      
ENSG00000115977 E022 11.6204166 0.176046504 1.824963e-01 4.072399e-01 2 69509251 69509460 210 -      
ENSG00000115977 E023 1.3452662 0.013632055 7.592469e-01   2 69509461 69509463 3 -      
ENSG00000115977 E024 0.3751086 0.032740671 3.860352e-01   2 69509464 69509493 30 -      
ENSG00000115977 E025 15.1855354 0.066826818 9.510851e-02 2.731681e-01 2 69514471 69514749 279 -      
ENSG00000115977 E026 21.7957422 0.023633341 1.916951e-01 4.190228e-01 2 69518954 69519240 287 -      
ENSG00000115977 E027 16.1188983 0.063452077 1.245958e-01 3.231041e-01 2 69520834 69520988 155 -      
ENSG00000115977 E028 12.8799258 0.069709744 3.466934e-02 1.407014e-01 2 69525033 69525112 80 -      
ENSG00000115977 E029 15.5958778 0.009646285 2.977012e-04 3.707304e-03 2 69527216 69527319 104 -      
ENSG00000115977 E030 14.3717539 0.043614236 1.115572e-03 1.078810e-02 2 69530008 69530140 133 -      
ENSG00000115977 E031 13.5012609 0.129558420 1.765683e-01 3.991608e-01 2 69530625 69530706 82 -      
ENSG00000115977 E032 0.0000000       2 69531717 69532040 324 -      
ENSG00000115977 E033 17.9200588 0.097142638 2.153990e-01 4.479513e-01 2 69532041 69532162 122 -      
ENSG00000115977 E034 16.9046000 0.162113231 1.488262e-01 3.606518e-01 2 69542523 69542665 143 -      
ENSG00000115977 E035 0.0000000       2 69544239 69544435 197 -      
ENSG00000115977 E036 16.2342276 0.142076517 4.919198e-02 1.776676e-01 2 69544436 69544544 109 -      
ENSG00000115977 E037 16.0047042 0.136727357 2.176200e-02 1.018124e-01 2 69556860 69556978 119 -      
ENSG00000115977 E038 0.1614157 0.032563609 3.040462e-01   2 69642877 69642877 1 -      
ENSG00000115977 E039 10.1414791 0.135213460 4.535938e-03 3.212824e-02 2 69642878 69642905 28 -      
ENSG00000115977 E040 11.8398142 0.004920876 3.720548e-06 8.917919e-05 2 69642906 69643040 135 -      
ENSG00000115977 E041 3.8692189 0.006979277 1.237480e-01 3.216441e-01 2 69643041 69643084 44 -      
ENSG00000115977 E042 2.3999816 0.009137643 9.679408e-02 2.761042e-01 2 69643085 69643092 8 -      
ENSG00000115977 E043 2.8528733 0.009079625 3.239753e-01 5.632914e-01 2 69643093 69643146 54 -      
ENSG00000115977 E044 4.6296620 0.039146489 7.440555e-01 8.630339e-01 2 69643147 69643274 128 -      
ENSG00000115977 E045 3.6359217 0.007900039 7.374359e-01 8.589231e-01 2 69643575 69643742 168 -      
ENSG00000115977 E046 0.3453689 0.026483435 7.314215e-01   2 69643743 69643791 49 -      
ENSG00000115977 E047 1.0939410 0.197967255 6.990889e-01   2 69643792 69643960 169 -      
ENSG00000115977 E048 0.0000000       2 69674023 69674349 327 -