ENSG00000115935

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272746 ENSG00000115935 HEK293_OSMI2_6hA HEK293_TMG_6hB WIPF1 protein_coding protein_coding 6.835054 5.461353 6.618565 1.034303 0.5599333 0.2767989 0.4132884 0.1044376 0.6647528 0.10443758 0.35693211 2.5597981 0.05438750 0.01540000 0.09233333 0.07693333 0.68112843 0.02569114 FALSE  
ENST00000359761 ENSG00000115935 HEK293_OSMI2_6hA HEK293_TMG_6hB WIPF1 protein_coding protein_coding 6.835054 5.461353 6.618565 1.034303 0.5599333 0.2767989 0.8802262 0.8130030 1.3151297 0.17218537 0.85791856 0.6871640 0.11823750 0.15106667 0.22430000 0.07323333 1.00000000 0.02569114 FALSE  
ENST00000392547 ENSG00000115935 HEK293_OSMI2_6hA HEK293_TMG_6hB WIPF1 protein_coding protein_coding 6.835054 5.461353 6.618565 1.034303 0.5599333 0.2767989 3.9569450 3.2923030 3.5321849 0.83157086 0.89717029 0.1011670 0.57652917 0.58350000 0.52036667 -0.06313333 0.92953293 0.02569114 FALSE  
ENST00000409415 ENSG00000115935 HEK293_OSMI2_6hA HEK293_TMG_6hB WIPF1 protein_coding protein_coding 6.835054 5.461353 6.618565 1.034303 0.5599333 0.2767989 0.2919296 0.4238586 0.1282468 0.09225556 0.04990977 -1.6499785 0.04875833 0.07720000 0.01850000 -0.05870000 0.02569114 0.02569114 FALSE  
ENST00000487291 ENSG00000115935 HEK293_OSMI2_6hA HEK293_TMG_6hB WIPF1 protein_coding processed_transcript 6.835054 5.461353 6.618565 1.034303 0.5599333 0.2767989 0.9951617 0.4805420 0.7295287 0.05515269 0.18529298 0.5922295 0.15386667 0.09736667 0.10750000 0.01013333 0.95688404 0.02569114    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115935 E001 0.7193800 0.026711020 0.797103846   2 174559572 174559573 2 - 0.233 0.274 0.310
ENSG00000115935 E002 98.5943044 0.521896355 0.314566325 0.55477678 2 174559574 174560769 1196 - 1.937 2.039 0.342
ENSG00000115935 E003 146.5573534 1.007650053 0.600179556 0.77032418 2 174560770 174562125 1356 - 2.192 2.145 -0.158
ENSG00000115935 E004 19.1293768 0.051217526 0.826713542 0.91189253 2 174562126 174562203 78 - 1.363 1.259 -0.361
ENSG00000115935 E005 12.6373529 0.005162019 0.638149707 0.79581306 2 174562204 174562210 7 - 1.180 1.115 -0.234
ENSG00000115935 E006 54.3847989 0.330750439 0.407590086 0.63418545 2 174562211 174562550 340 - 1.736 1.745 0.031
ENSG00000115935 E007 32.0917638 0.169374364 0.542907673 0.73115734 2 174562551 174562602 52 - 1.518 1.519 0.002
ENSG00000115935 E008 0.8818932 0.028754942 0.785090922   2 174566161 174567069 909 - 0.233 0.275 0.320
ENSG00000115935 E009 23.7434511 0.014143200 0.649340518 0.80303053 2 174567070 174567076 7 - 1.383 1.401 0.063
ENSG00000115935 E010 40.3616984 0.001064183 0.861776984 0.93128170 2 174567077 174567183 107 - 1.635 1.612 -0.080
ENSG00000115935 E011 47.1709371 0.082869814 0.704503224 0.83845485 2 174567861 174568073 213 - 1.684 1.680 -0.012
ENSG00000115935 E012 0.6901176 0.189141876 0.420929624   2 174568607 174568823 217 - 0.131 0.279 1.351
ENSG00000115935 E013 0.6182515 0.113363681 0.422659939   2 174570439 174570646 208 - 0.131 0.274 1.315
ENSG00000115935 E014 4.5961952 0.005772127 0.005497579 0.03720473 2 174571169 174571675 507 - 0.495 0.889 1.663
ENSG00000115935 E015 91.7167805 0.204639950 0.461719734 0.67432023 2 174571676 174572323 648 - 1.998 1.936 -0.209
ENSG00000115935 E016 30.9576318 0.058003974 0.884616927 0.94373219 2 174572324 174572446 123 - 1.497 1.514 0.059
ENSG00000115935 E017 0.0000000       2 174574730 174574941 212 -      
ENSG00000115935 E018 16.0170076 0.002516869 0.007866347 0.04870344 2 174575204 174575262 59 - 1.104 1.321 0.769
ENSG00000115935 E019 17.8551853 0.025256838 0.557960182 0.74182796 2 174575263 174575371 109 - 1.266 1.286 0.071
ENSG00000115935 E020 10.3957006 0.107137576 0.779012164 0.88417756 2 174575372 174575380 9 - 1.116 0.993 -0.448
ENSG00000115935 E021 0.3447487 0.966781234 0.532489077   2 174581140 174581309 170 - 0.000 0.205 12.118
ENSG00000115935 E022 23.6424821 0.043165825 0.398566470 0.62712641 2 174581310 174581439 130 - 1.437 1.342 -0.331
ENSG00000115935 E023 18.5789978 0.159018104 0.633107051 0.79237466 2 174585523 174585611 89 - 1.306 1.271 -0.122
ENSG00000115935 E024 0.4950181 0.021768165 0.709801258   2 174597601 174597858 258 - 0.132 0.201 0.726
ENSG00000115935 E025 0.1308682 0.033549512 0.622922357   2 174598171 174598175 5 - 0.000 0.112 11.073
ENSG00000115935 E026 0.1308682 0.033549512 0.622922357   2 174598176 174598211 36 - 0.000 0.112 11.073
ENSG00000115935 E027 0.0000000       2 174623481 174623508 28 -      
ENSG00000115935 E028 0.0000000       2 174625624 174625709 86 -      
ENSG00000115935 E029 0.0000000       2 174625710 174625820 111 -      
ENSG00000115935 E030 0.0000000       2 174625821 174625856 36 -      
ENSG00000115935 E031 0.1614157 0.033701168 0.409929377   2 174625857 174625960 104 - 0.132 0.000 -11.659
ENSG00000115935 E032 0.3337900 0.045553369 1.000000000   2 174629666 174629868 203 - 0.132 0.112 -0.272
ENSG00000115935 E033 0.0000000       2 174630382 174630560 179 -      
ENSG00000115935 E034 0.0000000       2 174630561 174630625 65 -      
ENSG00000115935 E035 0.0000000       2 174630626 174630696 71 -      
ENSG00000115935 E036 0.3040503 0.025893099 0.162312111   2 174634518 174634605 88 - 0.233 0.000 -12.658
ENSG00000115935 E037 1.8577777 0.312737756 0.593821756 0.76625156 2 174673267 174673816 550 - 0.503 0.394 -0.561
ENSG00000115935 E038 4.7299299 0.029095865 0.262131952 0.50127847 2 174676337 174676666 330 - 0.846 0.657 -0.764
ENSG00000115935 E039 3.2688679 0.186844014 0.755793582 0.87008070 2 174677045 174677124 80 - 0.587 0.656 0.303
ENSG00000115935 E040 15.1318530 0.108247766 0.352659674 0.58969909 2 174682774 174682916 143 - 1.267 1.145 -0.431