ENSG00000115840

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263812 ENSG00000115840 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A12 protein_coding nonsense_mediated_decay 9.585046 3.478199 17.77575 0.4216075 0.7158572 2.350168 4.7046627 1.7750252 9.1011410 0.19444551 0.3312326 2.3516873 0.48142500 0.5144667 0.5122000 -0.002266667 1.000000e+00 8.109027e-09 FALSE TRUE
ENST00000422440 ENSG00000115840 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A12 protein_coding protein_coding 9.585046 3.478199 17.77575 0.4216075 0.7158572 2.350168 2.1397758 0.7672996 3.7394382 0.11922653 0.2299591 2.2701317 0.22645417 0.2191333 0.2107333 -0.008400000 9.850200e-01 8.109027e-09 FALSE TRUE
ENST00000472070 ENSG00000115840 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A12 protein_coding retained_intron 9.585046 3.478199 17.77575 0.4216075 0.7158572 2.350168 0.6541941 0.4776599 1.2485600 0.04760541 0.1140005 1.3678267 0.08383750 0.1457667 0.0702000 -0.075566667 2.955301e-01 8.109027e-09 FALSE TRUE
ENST00000472748 ENSG00000115840 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A12 protein_coding processed_transcript 9.585046 3.478199 17.77575 0.4216075 0.7158572 2.350168 1.2369640 0.0000000 2.8593197 0.00000000 0.4276638 8.1645649 0.10265000 0.0000000 0.1599333 0.159933333 8.109027e-09 8.109027e-09 FALSE FALSE
ENST00000484227 ENSG00000115840 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A12 protein_coding processed_transcript 9.585046 3.478199 17.77575 0.4216075 0.7158572 2.350168 0.4951029 0.3771950 0.6002766 0.14647324 0.1016757 0.6564027 0.07129167 0.1002333 0.0340000 -0.066233333 2.709022e-01 8.109027e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115840 E001 49.4308660 0.0007986200 0.2455615023 0.483071877 2 171783405 171784774 1370 - 1.591 1.663 0.243
ENSG00000115840 E002 13.1487151 0.0035286948 0.0916429236 0.266750945 2 171784775 171784831 57 - 1.012 1.193 0.653
ENSG00000115840 E003 145.3438463 0.0004492534 0.0005205289 0.005860586 2 171784832 171785475 644 - 2.038 2.157 0.397
ENSG00000115840 E004 55.0006016 0.0007565407 0.1185052627 0.313393321 2 171787571 171787661 91 - 1.632 1.721 0.305
ENSG00000115840 E005 62.9683026 0.0072318639 0.1623448850 0.380262660 2 171787789 171787947 159 - 1.689 1.779 0.303
ENSG00000115840 E006 24.2398424 0.0029457146 0.0209027064 0.099017024 2 171787948 171788942 995 - 1.259 1.450 0.663
ENSG00000115840 E007 66.0764315 0.0034545102 0.1313613305 0.333949720 2 171791451 171791589 139 - 1.708 1.796 0.295
ENSG00000115840 E008 66.0994957 0.0092202207 0.6333490325 0.792536299 2 171793627 171793767 141 - 1.720 1.752 0.107
ENSG00000115840 E009 0.1614157 0.0329692704 1.0000000000   2 171809425 171809605 181 - 0.063 0.000 -8.476
ENSG00000115840 E010 48.7209107 0.0089643522 0.3995109591 0.627882176 2 171809606 171809686 81 - 1.608 1.541 -0.227
ENSG00000115840 E011 40.3171364 0.0012259968 0.4802860361 0.687268842 2 171810224 171810276 53 - 1.526 1.479 -0.161
ENSG00000115840 E012 1.8919797 0.0100760583 0.8177304700 0.906801802 2 171810277 171810280 4 - 0.410 0.366 -0.247
ENSG00000115840 E013 61.1058638 0.0029051588 0.3291295579 0.568137126 2 171813339 171813497 159 - 1.706 1.649 -0.192
ENSG00000115840 E014 0.7743180 0.0175599680 1.0000000000   2 171815109 171815120 12 - 0.212 0.220 0.073
ENSG00000115840 E015 39.5367001 0.0008928433 0.9514206716 0.977690383 2 171815121 171815202 82 - 1.509 1.516 0.022
ENSG00000115840 E016 50.8522268 0.0007797138 0.6400361162 0.796921009 2 171826798 171826882 85 - 1.622 1.596 -0.090
ENSG00000115840 E017 49.4725855 0.0018220029 0.9526705297 0.978341310 2 171833963 171834030 68 - 1.605 1.603 -0.006
ENSG00000115840 E018 39.5107401 0.0036028422 0.4079991540 0.634456504 2 171834031 171834056 26 - 1.521 1.460 -0.208
ENSG00000115840 E019 1.3981790 0.0123359146 0.3273856687 0.566478679 2 171834057 171834335 279 - 0.289 0.475 1.073
ENSG00000115840 E020 75.6208033 0.0006190249 0.0869510782 0.258156488 2 171834727 171834865 139 - 1.798 1.711 -0.295
ENSG00000115840 E021 41.3795229 0.0009785933 0.4928583475 0.695885896 2 171837121 171837148 28 - 1.534 1.489 -0.155
ENSG00000115840 E022 65.8615616 0.0008008382 0.3917982837 0.621864199 2 171837149 171837267 119 - 1.732 1.687 -0.152
ENSG00000115840 E023 62.9894088 0.0007401494 0.0806389905 0.246128556 2 171844369 171844508 140 - 1.722 1.624 -0.333
ENSG00000115840 E024 0.4632531 0.0272896148 0.6500613892   2 171845727 171845858 132 - 0.168 0.000 -10.031
ENSG00000115840 E025 0.5255656 0.2672433690 0.5412835633   2 171848173 171848276 104 - 0.119 0.224 1.098
ENSG00000115840 E026 0.6603779 0.1003739769 0.1794633802   2 171852668 171852688 21 - 0.118 0.369 2.099
ENSG00000115840 E027 2.1262415 0.2958913409 0.8210704870 0.908624801 2 171855801 171855833 33 - 0.404 0.491 0.449
ENSG00000115840 E028 46.8586427 0.0008698984 0.0066016350 0.042710559 2 171855834 171855926 93 - 1.614 1.428 -0.634
ENSG00000115840 E029 26.6251631 0.0021570339 0.0039444828 0.028836156 2 171855927 171855949 23 - 1.385 1.111 -0.966
ENSG00000115840 E030 54.5270584 0.0016275116 0.0349546034 0.141458729 2 171868681 171868823 143 - 1.672 1.541 -0.449
ENSG00000115840 E031 29.9931081 0.0019282204 0.2227087790 0.456654910 2 171893205 171893258 54 - 1.417 1.319 -0.340
ENSG00000115840 E032 22.1771205 0.0025298890 0.6430480374 0.798861352 2 171894203 171894244 42 - 1.284 1.244 -0.140
ENSG00000115840 E033 0.1426347 0.0324517784 1.0000000000   2 171921080 171921231 152 - 0.063 0.000 -8.475
ENSG00000115840 E034 2.1725990 0.0105874289 0.0065127355 0.042269062 2 171991347 171991442 96 - 0.289 0.751 2.297
ENSG00000115840 E035 1.2191997 0.0139266522 0.0008126002   2 171999679 171999859 181 - 0.119 0.696 3.656