ENSG00000115839

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264158 ENSG00000115839 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB3GAP1 protein_coding protein_coding 23.07684 9.465056 38.79889 1.441995 1.535613 2.034181 13.845145 6.445757 21.23801 1.5874027 1.0739082 1.718669 0.6393625 0.6582000 0.5469 -0.1113000 0.67519536 0.03694302 FALSE TRUE
MSTRG.19280.2 ENSG00000115839 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB3GAP1 protein_coding   23.07684 9.465056 38.79889 1.441995 1.535613 2.034181 6.162842 1.259026 12.53109 0.1451686 0.8644146 3.304869 0.2015417 0.1432667 0.3222 0.1789333 0.03694302 0.03694302 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115839 E001 0.3150090 0.0321232064 3.825434e-01   2 135052276 135052278 3 + 0.070 0.203 1.772
ENSG00000115839 E002 1.0422113 0.0155518983 2.639374e-01   2 135052279 135052288 10 + 0.230 0.445 1.353
ENSG00000115839 E003 1.3628298 0.0129155569 5.062567e-01   2 135052289 135052291 3 + 0.311 0.445 0.768
ENSG00000115839 E004 2.1548837 0.0111849223 6.566722e-01 0.8077388347 2 135052292 135052292 1 + 0.438 0.529 0.449
ENSG00000115839 E005 2.3162994 0.0099408198 7.682883e-01 0.8775956017 2 135052293 135052293 1 + 0.465 0.529 0.311
ENSG00000115839 E006 4.4703050 0.0055739949 1.498589e-01 0.3621002321 2 135052294 135052294 1 + 0.617 0.842 0.922
ENSG00000115839 E007 8.8415068 0.0035050713 1.668181e-02 0.0842915594 2 135052295 135052297 3 + 0.841 1.131 1.076
ENSG00000115839 E008 8.8415068 0.0035050713 1.668181e-02 0.0842915594 2 135052298 135052298 1 + 0.841 1.131 1.076
ENSG00000115839 E009 42.1986443 0.0008946866 1.363288e-02 0.0729016123 2 135052299 135052305 7 + 1.594 1.444 -0.513
ENSG00000115839 E010 42.9839210 0.0008966997 2.062696e-02 0.0981094413 2 135052306 135052307 2 + 1.600 1.462 -0.470
ENSG00000115839 E011 76.1842097 0.0021885685 6.978945e-02 0.2243819471 2 135052308 135052325 18 + 1.833 1.752 -0.276
ENSG00000115839 E012 113.2152881 0.0014981854 9.395585e-02 0.2710678134 2 135052430 135052485 56 + 1.996 1.939 -0.191
ENSG00000115839 E013 0.3228314 0.4069612854 1.000000e+00   2 135056391 135056600 210 + 0.131 0.000 -9.933
ENSG00000115839 E014 159.9468202 0.0004638694 3.964141e-03 0.0289474659 2 135058011 135058086 76 + 2.150 2.067 -0.278
ENSG00000115839 E015 23.2825201 0.0166849325 9.151825e-01 0.9597501860 2 135058087 135059066 980 + 1.304 1.329 0.086
ENSG00000115839 E016 14.5961183 0.0027870619 1.228088e-02 0.0675643097 2 135060281 135060537 257 + 1.047 1.302 0.910
ENSG00000115839 E017 41.6137874 0.0263184797 4.378912e-03 0.0312571940 2 135060538 135062781 2244 + 1.472 1.759 0.977
ENSG00000115839 E018 0.3337900 0.0380741112 3.843814e-01   2 135089654 135089872 219 + 0.070 0.203 1.770
ENSG00000115839 E019 204.3328579 0.0003056422 6.336768e-07 0.0000191012 2 135090998 135091130 133 + 2.266 2.129 -0.460
ENSG00000115839 E020 123.6186656 0.0004416045 1.783689e-03 0.0155887582 2 135093615 135093685 71 + 2.044 1.938 -0.355
ENSG00000115839 E021 74.2536123 0.0022741781 4.636572e-02 0.1709538927 2 135093686 135093693 8 + 1.823 1.732 -0.306
ENSG00000115839 E022 175.2966193 0.0045519447 9.128399e-04 0.0092011643 2 135113151 135113270 120 + 2.199 2.063 -0.454
ENSG00000115839 E023 221.0658015 0.0034114214 1.915276e-02 0.0929759708 2 135115216 135115381 166 + 2.288 2.214 -0.248
ENSG00000115839 E024 184.0922872 0.0003412115 4.208207e-02 0.1601313892 2 135120819 135120918 100 + 2.205 2.158 -0.155
ENSG00000115839 E025 0.0000000       2 135124080 135124164 85 +      
ENSG00000115839 E026 185.1460652 0.0003187032 3.433448e-03 0.0259547537 2 135124165 135124246 82 + 2.213 2.138 -0.251
ENSG00000115839 E027 133.3546599 0.0003746325 9.628827e-02 0.2752299586 2 135126181 135126249 69 + 2.067 2.024 -0.145
ENSG00000115839 E028 0.1779838 0.0385584218 1.000000e+00   2 135126250 135126582 333 + 0.070 0.000 -8.929
ENSG00000115839 E029 102.1976566 0.0009373162 4.635861e-01 0.6755354851 2 135126583 135126656 74 + 1.947 1.935 -0.041
ENSG00000115839 E030 123.2728288 0.0023518364 7.111613e-01 0.8425521485 2 135129995 135130087 93 + 2.021 2.026 0.018
ENSG00000115839 E031 142.4489216 0.0004568657 9.103940e-01 0.9573568510 2 135130552 135130721 170 + 2.080 2.102 0.074
ENSG00000115839 E032 113.7708753 0.0003394006 2.233259e-01 0.4573570314 2 135132895 135132984 90 + 1.995 1.964 -0.102
ENSG00000115839 E033 180.2580897 0.0025259839 2.238323e-01 0.4580185458 2 135133861 135134033 173 + 2.191 2.164 -0.091
ENSG00000115839 E034 124.8244526 0.0041444983 3.962293e-01 0.6253552911 2 135135265 135135319 55 + 2.031 2.011 -0.066
ENSG00000115839 E035 311.1817310 0.0035895185 4.453678e-01 0.6623495726 2 135135564 135135932 369 + 2.423 2.416 -0.023
ENSG00000115839 E036 0.3040503 0.0244411696 8.313823e-01   2 135148814 135150368 1555 + 0.130 0.000 -9.926
ENSG00000115839 E037 166.7524401 0.0003414954 8.368202e-01 0.9176879074 2 135150369 135150506 138 + 2.151 2.162 0.037
ENSG00000115839 E038 5.0852437 0.1117058143 5.784417e-01 0.7561015348 2 135150507 135153648 3142 + 0.685 0.811 0.508
ENSG00000115839 E039 193.3945744 0.0198750499 2.936849e-01 0.5343175933 2 135153649 135153876 228 + 2.196 2.277 0.268
ENSG00000115839 E040 6.9489607 0.0729670184 4.081816e-01 0.6346058148 2 135153877 135155215 1339 + 0.863 0.717 -0.583
ENSG00000115839 E041 10.1289650 0.0514022930 2.376316e-01 0.4738346353 2 135159627 135160929 1303 + 0.926 1.110 0.679
ENSG00000115839 E042 9.2344772 0.1111260441 1.205187e-01 0.3166569839 2 135160930 135161939 1010 + 0.847 1.154 1.136
ENSG00000115839 E043 2.4643329 0.0089226499 5.794943e-03 0.0387218029 2 135161940 135162382 443 + 0.347 0.803 2.130
ENSG00000115839 E044 2.6663973 0.2343161723 1.224347e-01 0.3196470937 2 135162383 135162554 172 + 0.403 0.764 1.652
ENSG00000115839 E045 124.2883561 0.1957277402 2.444611e-01 0.4816194738 2 135162555 135162651 97 + 1.976 2.155 0.600
ENSG00000115839 E046 1.0226225 0.0918818609 1.430362e-02   2 135162652 135162747 96 + 0.129 0.596 3.082
ENSG00000115839 E047 170.0820548 0.0206447365 2.782320e-01 0.5183443059 2 135162748 135162851 104 + 2.139 2.224 0.284
ENSG00000115839 E048 0.0000000       2 135162852 135162937 86 +      
ENSG00000115839 E049 0.1426347 0.0317763028 1.000000e+00   2 135162938 135162985 48 + 0.070 0.000 -8.925
ENSG00000115839 E050 214.7128272 0.0004086198 1.009386e-01 0.2834790110 2 135162986 135163101 116 + 2.246 2.310 0.213
ENSG00000115839 E051 181.6831098 0.0002474850 4.472464e-02 0.1669290556 2 135164594 135164696 103 + 2.171 2.249 0.260
ENSG00000115839 E052 1.9787983 0.1380324889 9.308406e-02 0.2694452614 2 135164697 135164803 107 + 0.313 0.661 1.760
ENSG00000115839 E053 2.9458873 0.0083298061 9.076069e-01 0.9559495352 2 135164804 135166131 1328 + 0.538 0.529 -0.038
ENSG00000115839 E054 0.0000000       2 135167693 135167713 21 +      
ENSG00000115839 E055 0.3751086 0.0277601271 2.945662e-02   2 135168254 135168434 181 + 0.000 0.341 13.435
ENSG00000115839 E056 94.7901488 0.0010837772 1.393457e-01 0.3465198501 2 135168545 135168547 3 + 1.892 1.972 0.271
ENSG00000115839 E057 231.1722398 0.0002420731 1.754055e-03 0.0153950537 2 135168548 135168749 202 + 2.269 2.369 0.335
ENSG00000115839 E058 456.2130848 0.0070530405 1.394030e-02 0.0741011451 2 135168750 135169733 984 + 2.551 2.683 0.438
ENSG00000115839 E059 66.5026656 0.0005332690 5.277312e-01 0.7204216337 2 135169734 135169848 115 + 1.746 1.795 0.166
ENSG00000115839 E060 96.8836497 0.0053328318 5.103910e-02 0.1821654183 2 135169849 135170710 862 + 1.885 2.009 0.416
ENSG00000115839 E061 4.5694873 0.0067371193 4.040108e-05 0.0006938747 2 135175327 135175588 262 + 0.466 1.047 2.398
ENSG00000115839 E062 2.3736156 0.0122244767 3.344912e-03 0.0254508965 2 135176249 135176669 421 + 0.312 0.803 2.349