ENSG00000115825

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234179 ENSG00000115825 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD3 protein_coding protein_coding 16.498 5.894702 32.20155 1.824876 1.184624 2.447642 6.2217109 2.0442512 13.599635 1.0010884 0.1214426 2.7279439 0.3662583 0.29863333 0.42326667 0.12463333 0.6601217 0.002836199 FALSE TRUE
ENST00000379066 ENSG00000115825 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD3 protein_coding protein_coding 16.498 5.894702 32.20155 1.824876 1.184624 2.447642 1.4256531 0.9974647 1.411917 0.5922771 1.0703080 0.4971076 0.1922208 0.23253333 0.04256667 -0.18996667 0.7892527 0.002836199 FALSE TRUE
MSTRG.18232.1 ENSG00000115825 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD3 protein_coding   16.498 5.894702 32.20155 1.824876 1.184624 2.447642 2.4086253 0.7499737 4.155193 0.3750045 0.7414918 2.4543621 0.1146250 0.09863333 0.12983333 0.03120000 0.8800178 0.002836199 FALSE TRUE
MSTRG.18232.4 ENSG00000115825 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD3 protein_coding   16.498 5.894702 32.20155 1.824876 1.184624 2.447642 4.1469692 1.5933948 9.179643 0.6769544 1.4781946 2.5188792 0.1954958 0.27120000 0.28240000 0.01120000 0.9887679 0.002836199 FALSE TRUE
MSTRG.18232.9 ENSG00000115825 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKD3 protein_coding   16.498 5.894702 32.20155 1.824876 1.184624 2.447642 0.8922437 0.0000000 1.781890 0.0000000 0.8790067 7.4853386 0.0429750 0.00000000 0.05753333 0.05753333 0.0267320 0.002836199 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115825 E001 758.0948724 0.0014505620 0.1827826134 0.407614925 2 37250502 37253218 2717 - 2.764 2.831 0.223
ENSG00000115825 E002 77.5261350 1.2714288447 0.3923511097 0.622276372 2 37253219 37253246 28 - 1.720 2.010 0.976
ENSG00000115825 E003 91.4626976 1.3217104994 0.3807833132 0.612846883 2 37253247 37253307 61 - 1.784 2.095 1.046
ENSG00000115825 E004 62.8824526 0.9431950520 0.3165862901 0.556592818 2 37253308 37253324 17 - 1.626 1.930 1.027
ENSG00000115825 E005 55.7646894 0.9088609336 0.2990223112 0.539453090 2 37253325 37253325 1 - 1.577 1.875 1.008
ENSG00000115825 E006 69.8211796 0.9761069788 0.3134276918 0.553642389 2 37253326 37253350 25 - 1.673 1.970 1.002
ENSG00000115825 E007 102.7035446 0.0747380688 0.0689191774 0.222602642 2 37254204 37254289 86 - 1.855 2.100 0.822
ENSG00000115825 E008 91.7765704 0.0004793444 0.1021244454 0.285574471 2 37256662 37256697 36 - 1.847 1.958 0.374
ENSG00000115825 E009 186.2192815 0.0049082719 0.4019532284 0.630010868 2 37256698 37256929 232 - 2.155 2.241 0.287
ENSG00000115825 E010 107.3160648 0.0068713714 0.7588244389 0.871839149 2 37259583 37259681 99 - 1.923 1.984 0.205
ENSG00000115825 E011 143.8020989 0.0012458065 0.4387062608 0.657782538 2 37260223 37260355 133 - 2.046 2.115 0.229
ENSG00000115825 E012 86.7651421 0.0006025599 0.4005499938 0.628746584 2 37260356 37260384 29 - 1.826 1.904 0.263
ENSG00000115825 E013 122.4107020 0.0040344015 0.6967440669 0.833473047 2 37267430 37267536 107 - 1.986 2.002 0.054
ENSG00000115825 E014 2.5295622 0.0317930202 0.5643032865 0.746311938 2 37267565 37268300 736 - 0.434 0.567 0.652
ENSG00000115825 E015 1.6147050 0.0119884307 0.1610774624 0.378418517 2 37268301 37268372 72 - 0.286 0.566 1.528
ENSG00000115825 E016 8.4534297 0.0714392030 0.4449040129 0.662081057 2 37268373 37269614 1242 - 0.857 0.987 0.489
ENSG00000115825 E017 93.1107873 0.0127473569 0.4519774817 0.667108518 2 37269615 37269687 73 - 1.877 1.845 -0.109
ENSG00000115825 E018 71.0508857 0.0082189273 0.9760588888 0.989825981 2 37272380 37272429 50 - 1.750 1.779 0.097
ENSG00000115825 E019 41.9562017 0.0010068748 0.2515780603 0.489626627 2 37272430 37272432 3 - 1.543 1.503 -0.138
ENSG00000115825 E020 187.4996559 0.0018332716 0.0089424954 0.053561930 2 37274421 37274697 277 - 2.185 2.125 -0.200
ENSG00000115825 E021 115.5427293 0.0005110303 0.0314027399 0.131494908 2 37275767 37275844 78 - 1.978 1.928 -0.168
ENSG00000115825 E022 149.0949678 0.0057469670 0.0796427693 0.244119089 2 37277866 37277989 124 - 2.084 2.039 -0.150
ENSG00000115825 E023 2.0711312 0.0107739940 0.6708071737 0.816865914 2 37277990 37279390 1401 - 0.432 0.370 -0.344
ENSG00000115825 E024 166.4488635 0.0081838612 0.0320114820 0.133252099 2 37279746 37279929 184 - 2.137 2.060 -0.258
ENSG00000115825 E025 0.7860845 0.0169055054 0.3252361538   2 37282306 37282541 236 - 0.249 0.001 -9.304
ENSG00000115825 E026 97.8449494 0.0039245305 0.0935098553 0.270217196 2 37282542 37282619 78 - 1.903 1.855 -0.161
ENSG00000115825 E027 93.6806515 0.0087404535 0.0241996448 0.109690287 2 37286177 37286231 55 - 1.892 1.793 -0.334
ENSG00000115825 E028 125.2373501 0.0110384111 0.1095565308 0.298338628 2 37286232 37286369 138 - 2.009 1.960 -0.163
ENSG00000115825 E029 113.9435584 0.0084601879 0.4197056630 0.643450676 2 37289356 37289513 158 - 1.961 1.969 0.026
ENSG00000115825 E030 129.8601914 0.0041069688 0.0160229754 0.081898262 2 37290868 37290999 132 - 2.029 1.952 -0.258
ENSG00000115825 E031 2.2788548 0.0131564723 0.8940357127 0.948729713 2 37292988 37293132 145 - 0.432 0.479 0.241
ENSG00000115825 E032 127.0416738 0.0008669863 0.0024516567 0.020017516 2 37293133 37293271 139 - 2.023 1.935 -0.295
ENSG00000115825 E033 95.0720614 0.0164322784 0.1391911084 0.346306629 2 37316237 37316451 215 - 1.897 1.812 -0.289
ENSG00000115825 E034 116.0823758 0.0094161252 0.0464988809 0.171288680 2 37316452 37316813 362 - 1.983 1.886 -0.328
ENSG00000115825 E035 117.9873196 0.0035200746 0.0006620379 0.007115776 2 37316814 37317179 366 - 1.996 1.857 -0.467
ENSG00000115825 E036 15.8924589 0.0056948847 0.8045206983 0.898927011 2 37317787 37317899 113 - 1.128 1.138 0.038
ENSG00000115825 E037 7.2267023 0.0040631176 0.3109618942 0.551370218 2 37324198 37324680 483 - 0.787 0.957 0.652
ENSG00000115825 E038 48.8457143 0.0010327604 0.0270875060 0.118547433 2 37324681 37324833 153 - 1.618 1.512 -0.362