ENSG00000115806

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234160 ENSG00000115806 HEK293_OSMI2_6hA HEK293_TMG_6hB GORASP2 protein_coding protein_coding 77.9368 62.52494 85.59282 11.43688 3.144372 0.4529958 59.344654 46.589642 63.042546 8.303025 3.1185666 0.4362358 0.76320833 0.7469667 0.73590000 -0.011066667 9.456523e-01 5.370015e-27 FALSE TRUE
ENST00000444801 ENSG00000115806 HEK293_OSMI2_6hA HEK293_TMG_6hB GORASP2 protein_coding nonsense_mediated_decay 77.9368 62.52494 85.59282 11.43688 3.144372 0.4529958 8.693451 9.477280 8.701035 2.273117 0.9279780 -0.1231504 0.11069583 0.1476000 0.10110000 -0.046500000 3.064258e-01 5.370015e-27 FALSE FALSE
ENST00000471559 ENSG00000115806 HEK293_OSMI2_6hA HEK293_TMG_6hB GORASP2 protein_coding processed_transcript 77.9368 62.52494 85.59282 11.43688 3.144372 0.4529958 2.051836 0.000000 7.283768 0.000000 0.7333342 9.5105205 0.02368333 0.0000000 0.08526667 0.085266667 5.370015e-27 5.370015e-27 FALSE FALSE
MSTRG.19463.6 ENSG00000115806 HEK293_OSMI2_6hA HEK293_TMG_6hB GORASP2 protein_coding   77.9368 62.52494 85.59282 11.43688 3.144372 0.4529958 4.384821 2.305857 4.447564 1.152976 0.7973649 0.9447092 0.05723750 0.0455000 0.05273333 0.007233333 9.128228e-01 5.370015e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000115806 E001 0.1779838 0.0349522096 5.339632e-01   2 170928464 170928560 97 + 0.117 0.000 -9.301
ENSG00000115806 E002 1.3042373 0.0129976227 1.951206e-02   2 170928892 170929126 235 + 0.117 0.527 2.944
ENSG00000115806 E003 1.6074798 0.0119541099 5.105224e-03 3.517892e-02 2 170929127 170929144 18 + 0.117 0.607 3.306
ENSG00000115806 E004 2.2914404 0.0095504615 3.485382e-03 2.625174e-02 2 170929145 170929155 11 + 0.208 0.704 2.721
ENSG00000115806 E005 3.8453400 0.0065225783 1.076589e-04 1.590321e-03 2 170929156 170929196 41 + 0.284 0.890 2.874
ENSG00000115806 E006 56.2821979 0.0008262159 3.250626e-06 7.949755e-05 2 170929197 170929252 56 + 1.629 1.856 0.767
ENSG00000115806 E007 56.2536413 0.0007599842 3.324687e-05 5.894230e-04 2 170929253 170929256 4 + 1.644 1.845 0.680
ENSG00000115806 E008 67.7056299 0.0033312890 3.583101e-04 4.321070e-03 2 170929257 170929266 10 + 1.733 1.917 0.623
ENSG00000115806 E009 161.8410512 0.0037348262 3.433709e-06 8.342242e-05 2 170929267 170929320 54 + 2.104 2.298 0.651
ENSG00000115806 E010 247.5984452 0.0025973186 7.658641e-04 7.993445e-03 2 170929321 170929403 83 + 2.332 2.451 0.394
ENSG00000115806 E011 0.3032425 0.0274424043 1.757685e-01   2 170929433 170929740 308 + 0.000 0.224 11.711
ENSG00000115806 E012 0.2027342 0.0321203341 4.442227e-01   2 170929741 170929816 76 + 0.000 0.127 10.639
ENSG00000115806 E013 2.9027022 0.2451354484 1.419056e-01 3.502993e-01 2 170929817 170929941 125 + 0.701 0.386 -1.488
ENSG00000115806 E014 0.6316833 0.0300385333 3.595332e-01   2 170936624 170936727 104 + 0.284 0.126 -1.453
ENSG00000115806 E015 211.0728790 0.0011250035 3.977988e-01 6.266094e-01 2 170948350 170948380 31 + 2.311 2.339 0.094
ENSG00000115806 E016 284.1106030 0.0015142294 3.226819e-01 5.620736e-01 2 170948381 170948430 50 + 2.463 2.440 -0.075
ENSG00000115806 E017 0.3337900 0.0314158345 9.435722e-01   2 170948431 170948761 331 + 0.117 0.127 0.138
ENSG00000115806 E018 716.2656228 0.0013329629 9.449042e-02 2.720739e-01 2 170949539 170949742 204 + 2.867 2.838 -0.095
ENSG00000115806 E019 1.8179344 0.3627062006 8.366605e-01 9.176356e-01 2 170949743 170949743 1 + 0.454 0.468 0.070
ENSG00000115806 E020 1.9869805 0.0106208992 4.659509e-01 6.772152e-01 2 170950032 170950203 172 + 0.405 0.528 0.624
ENSG00000115806 E021 537.2158400 0.0001198898 1.295027e-02 7.025245e-02 2 170950204 170950290 87 + 2.746 2.709 -0.124
ENSG00000115806 E022 598.1491538 0.0001763716 2.467479e-01 4.844432e-01 2 170951328 170951458 131 + 2.783 2.767 -0.054
ENSG00000115806 E023 1.0351266 0.0153787590 4.842787e-01   2 170951459 170951614 156 + 0.349 0.225 -0.862
ENSG00000115806 E024 12.3177997 0.0027320269 2.926226e-05 5.280984e-04 2 170953818 170954649 832 + 1.275 0.851 -1.550
ENSG00000115806 E025 561.3377690 0.0001488254 5.856808e-01 7.607100e-01 2 170954650 170954782 133 + 2.750 2.743 -0.023
ENSG00000115806 E026 262.5317299 0.0002142183 5.594869e-01 7.429394e-01 2 170956436 170956441 6 + 2.423 2.412 -0.039
ENSG00000115806 E027 371.3406554 0.0001541338 6.580329e-01 8.086921e-01 2 170956442 170956478 37 + 2.572 2.565 -0.023
ENSG00000115806 E028 511.1190595 0.0001897827 3.626553e-01 5.978784e-01 2 170956479 170956559 81 + 2.714 2.700 -0.045
ENSG00000115806 E029 295.9522078 0.0006788903 5.557514e-01 7.403175e-01 2 170961663 170961674 12 + 2.478 2.465 -0.045
ENSG00000115806 E030 476.2395292 0.0001972459 2.098375e-01 4.416423e-01 2 170961675 170961749 75 + 2.687 2.667 -0.067
ENSG00000115806 E031 539.3879039 0.0001438201 1.818068e-01 4.063780e-01 2 170962839 170962946 108 + 2.740 2.720 -0.066
ENSG00000115806 E032 1875.7101803 0.0005534635 7.565738e-01 8.705797e-01 2 170965790 170967130 1341 + 3.269 3.275 0.018